Marat R. Sadykov, Ph.D.

Understanding the physiological and metabolic processes of bacterial pathogens

My research is focused on understanding the physiological and metabolic processes governing fitness, virulence, and versatility of Gram-positive bacterial pathogens. Specifically, I am interested in: i) regulation of staphylococcal carbohydrate metabolism in response to various environmental cues and its contribution to fitness, virulence determinant production, and pathogenesis during infections; ii) metabolic and physiological basis of staphylococcal biofilm formation and its role in pathogenesis of biomaterial-related and nosocomial infections. My research interests also encompass contribution of the overflow and central carbohydrate metabolic pathways to fitness and sporulation of Bacillus anthracis.