Laboratory Research

Clinical research investigations extramurally and internally funded
Encompassing various cytogenetic and molecular cytogenetic investigations in hematological malignancies and solid tumors
-  In-depth investigations on genetic changes that have diagnostic and prognostic implications
-  Autism and developmental disabilities

Integral part of the Nebraska Lymphoma Study Group
A collaborative effort between community physicians and their counterparts at UNMC

Participation in industry sponsored clinical research 
-  Validation studies for new genetic diagnostic approaches
-  Enzyme replacement therapy, pharmacotherapy, natural history/outcome surveys in a variety of genetic disorders

Basic research studies (extramurally and internally funded)
Structure, pathology, function, and behavior of chromosomes
-  Oncology, prenatal health, birth defects, and other genetics-related projects
-  Culture and characterization of cell lines of human and non-human origin

Providing state-of-the-art cytogenetic and molecular genetic procedures to
Identify new breakpoints and understand the significance of chromosomal insults
-  Determine the role of genetic alterations in the etiology and progression of neoplasms
-  Focus on precision cancer medicine

Research contributions via publications and presentations by faculty and staff
Several manuscripts are published each year in peer-reviewed journals, with faculty and staff as authors/co-authors
-  Presentation of abstracts at various national/international conferences
-  Presentation of invited national/international research and educational seminars

Research opportunities are available for in-depth investigation of a variety of genetic changes. Cytogenetics, Fluorescence in situ Hybridization (FISH), Multi-color FISH, array based Comparative Genomic Hybridization (aCGH), and next generation sequencing techniques are applied to examine several constitutional and acquired genetic abnormalities. Prospective and retrospective studies can be performed on many different tissue types.

Faculty and staff would also welcome the opportunity to participate in case reports, chart reviews, or other small clinical research studies.

For more information please contact:
Bhavana J. Dave, Ph.D., FACMG  |  email