Martin Conda-Sheridan, Ph.D.

Assistant ProfessorDr. Conda-Sheridan

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-9361 (Office)
402-559-5673 (Fax)
Email
Curriculum Vitae
Center for Drug Delivery and Nanomedicine (CDDN) website

Research Activities/Interests: 
My main interests are the design of complex multifunctional biomaterials and bioactive small molecules for medicinal applications. The first area focuses on the preparation of self-assembling biomaterials with therapeutic potential against cancer and infectious diseases. These biomaterials will function as supramolecular drugs (nanodrugs) or as nanocarriers for the targeted delivery of novel small molecules. A second area of interest deals with the computer-aided rational drug design and synthesis of heterocyclic small molecules to treat bacterial infections and cancer. In order to do this my lab will get clues from nature and merge the principles of organic synthesis and medicinal chemistry in order to synthesize the molecules and improve their biological activity. Students in my lab will gain skills in diverse areas: computer-aided drug design, classic organic synthesis (including organometallic and peptide chemistry), traditional medicinal chemistry, and material sciences.  They will learn analytical and spectroscopic techniques, such as HPLC, IR, NMR, UV-Vis, ESI-MS, MALDI, DLS, Fluorescence microscopy, TEM, and CD.

Teaching Activities:
I am interested in teaching and developing courses in the general areas of Medicinal chemistry, Organic synthesis, Biomaterials, and Drug delivery.

Recent Publications:

  1. Samad, M. B.; Chhonker, Y. S.; Contreras, J. I.; McCarthy, A.; McClanahan, M., Murry, D. J., Conda-Sheridan, M.  Developing Polyamine-based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties. Macromol. Biosci.  ASAP
  2. Basiri, A.; Xiao, M.; Mc Carthy, A.; Dutta, D. Byrereddy, S. N.; Conda-Sheridan, M. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.  Bioorg. Med. Chem. Lett. 2017, 27, 228– 231
  3. Udumula, V*. ; Endres, J. L. ; Harper, C. N.; Jaramillo, L.; Zhong, H.;  Bayles, K. W. ; Conda-Sheridan, M*. A Simple Synthesis of Endophenazine G and Its Analogues and Their Biological Evaluation as anti-methicillin-resistant Staphylococcus aureus agents. Eur. J. Med. Chem. 2016, 128, 710– 721
  4. Conda-Sheridan, M.*; Lee, S. S.*; Preslar, A. T.; Stupp, S. I. Esterase-Activated Release of Naproxen from Supramolecular Nanofibres. Chem. Comm. 2014, 50, 13757– 13760
  5. Conda-Sheridan, M.*; Park, E. J.*; Beck, D. E.; Reddy, P. V. N.; Nguyen. T. X.; Hu, B.; Chen, L.; White J. J.; van Breemen, R. B.; Pezzuto, J. M.; Cushman, M. Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Rexinoids with Chemopreventive Potential J. Med. Chem., 2013, 56, 2561–2605
  6. Conda-Sheridan, M.*; Reddy, P. V. N.*; Morrell, A.; Chen, L.; van Breemen, R. B.; Park, E. J.; Kondratyuk, T. P.; Pezzuto, J. M.; Cushman, M. Synthesis and Biological Evaluation of Indenoisoquinolines That Inhibit Both Tyrosyl-DNA Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1). J. Med. Chem., 2013, 56, 182–200
  7. Conda-Sheridan, M.*; Chen, L.*; Reddy, P. V. N.; Morrell, A.; van Breemen, R. B.; Park, E. J.; Kondratyuk, T. P.; Pezzuto, J. M.; Cushman, M. Identification, Synthesis, and Biological Evaluation of the Metabolites of 3-Amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6–36), a Promising Rexinoid Lead Compound for the Development of Cancer Chemotherapeutic and Chemopreventive Agents. J. Med. Chem., 2012, 55, 5965–5981
  8. Nguyen, T. X.; Morrell, A.; Conda-Sheridan, M.; MArchand, C.; Agama, K.; Bermingam, A.; Stephen, A. G.; Chergui, A.; Naumova, A.; Fisher, R.; O’Keefe, B. R.; Pommier, Y.; Cushman, M. Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors. J. Med. Chem., 2012, 55, 4457–4478
  9. Park, E. J.; Kiselev, E.; Conda-Sheridan, M.; Cushman, M.; Pezzuto, J. M. Induction of Apoptosis by 3-Amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via Modulation of MAPKs (p38 and Jun N-terminal Kinase) and c-Myc in HL-60 Human Leukemia Cells. J. Nat. Prod., 2012, 75, 378–384
  10. Zhang, K. Conda-Sheridan, M.; Cooke, S. R.; Louie, J. N-Heterocyclic Carbenes Bound to Nickel(I) Complexes and Their Role in Catalysis. Organometallics, 2011, 30, 2546–2552