Martin Conda-Sheridan, Ph.D.

Assistant ProfessorDr. Conda-Sheridan

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-9361 (Office)
402-559-5673 (Fax)
Email
Curriculum Vitae
Center for Drug Delivery and Nanomedicine (CDDN) website

Research Activities/Interests: 
My main interests are the design of complex multifunctional biomaterials and bioactive small molecules for medicinal applications. The first area focuses on the preparation of self-assembling biomaterials with therapeutic potential against cancer and infectious diseases. These biomaterials will function as supramolecular drugs (nanodrugs) or as nanocarriers for the targeted delivery of novel small molecules. A second area of interest deals with the computer-aided rational drug design and synthesis of heterocyclic small molecules to treat bacterial infections and cancer. In order to do this my lab will get clues from nature and merge the principles of organic synthesis and medicinal chemistry in order to synthesize the molecules and improve their biological activity. Students in my lab will gain skills in diverse areas: computer-aided drug design, classic organic synthesis (including organometallic and peptide chemistry), traditional medicinal chemistry, and material sciences.  They will learn analytical and spectroscopic techniques, such as HPLC, IR, NMR, UV-Vis, ESI-MS, MALDI, DLS, Fluorescence microscopy, TEM, and CD.

Teaching Activities:
I am interested in teaching and developing courses in the general areas of Medicinal chemistry, Organic synthesis, Biomaterials, and Drug delivery.

Recent Publications:

  1. Krishnaiah, M.; Rodrigues de Almeida, N.; Udumula, V.; Song, Z.; Chhonker, Y. S.; Abdelmoaty, M. M.; Aragao do Nascimento, V.; Murry, D. J.; Conda-Sheridan, M. Synthesis, biological evaluation, and metabolic stability of new antibacterial phenazines. Eur. J. Med. Chem. 2018, 143, 936-947
  2. Dias de Oliveira, P.; Rodrigues de Almeida, N.; Conda-Sheridan, M.; do Prado Apparecido, R.; Michelettia, A. C.; Pereira Carvalhoc, N. C; dos Anjos dos Santos, E.; Marques, M. R.; de Arrudae, E. J.; Braz Alcantara, G.; Silva de Oliveira, L. C.; Pires de Lima, D.; Beatriz, A. Ozonolysis of neem oil: Preparation and characterization of potent antibacterial agents against multidrug resistant bacterial strains. RSC Advances. 2017, 7, 34356-3436
  3. Samad, M. B.; Chhonker, Y. S.; Contreras, J. I.; McCarthy, A.; McClanahan, M., Murry, D. J., Conda-Sheridan, M. Developing Polyamine-based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties. Macromol. Biosci. 2017 17, 1700096.
  4. Basiri, A.; Xiao, M.; Mc Carthy, A.; Dutta, D. Byrereddy, S. N.; Conda-Sheridan, M. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.  Bioorg. Med. Chem. Lett. 2017, 27, 228– 231
  5. Udumula, V*. ; Endres, J. L. ; Harper, C. N.; Jaramillo, L.; Zhong, H.;  Bayles, K. W. ; Conda-Sheridan, M*. A Simple Synthesis of Endophenazine G and Its Analogues and Their Biological Evaluation as anti-methicillin-resistant Staphylococcus aureus agents. Eur. J. Med. Chem. 2016, 128, 710– 721
  6. Conda-Sheridan, M.*; Lee, S. S.*; Preslar, A. T.; Stupp, S. I. Esterase-Activated Release of Naproxen from Supramolecular Nanofibres. Chem. Comm. 2014, 50, 13757– 13760
  7. Conda-Sheridan, M.*; Park, E. J.*; Beck, D. E.; Reddy, P. V. N.; Nguyen. T. X.; Hu, B.; Chen, L.; White J. J.; van Breemen, R. B.; Pezzuto, J. M.; Cushman, M. Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Rexinoids with Chemopreventive Potential. J. Med. Chem., 2013, 56, 2561–2605
  8. Conda-Sheridan, M.*; Reddy, P. V. N.*; Morrell, A.; Chen, L.; van Breemen, R. B.; Park, E. J.; Kondratyuk, T. P.; Pezzuto, J. M.; Cushman, M. Synthesis and Biological Evaluation of Indenoisoquinolines That Inhibit Both Tyrosyl-DNA Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1). J. Med. Chem., 2013, 56, 182–200
  9. Conda-Sheridan, M.*; Chen, L.*; Reddy, P. V. N.; Morrell, A.; van Breemen, R. B.; Park, E. J.; Kondratyuk, T. P.; Pezzuto, J. M.; Cushman, M.   Identification, Synthesis, and Biological Evaluation of the Metabolites of 3-Amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6–36), a Promising Rexinoid Lead Compound for the Development of Cancer Chemotherapeutic and Chemopreventive Agents. J. Med. Chem., 2012, 55, 5965–5981
  10. Nguyen, T. X.; Morrell, A.;  Conda-Sheridan, M.; MArchand, C.; Agama, K.; Bermingam, A.; Stephen, A. G.; Chergui, A.; Naumova, A.; Fisher, R.; O’Keefe, B. R.; Pommier, Y.; Cushman, M.   Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors.  J. Med. Chem., 2012, 55, 4457–4478