Yuxiang Dong, Ph.D.

Yuxiang Dong, Ph.D.Research Associate Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-4635 (Lab)
402-559-5673 (Fax)
Email

Teaching Activities:
Dr. Dong is currently pursuing teaching opportunities in the areas of Medicinal Chemistry and Organic Chemistry.

Research Activities/Interests:
Our research interests are in the discovery and development of new drug candidates against the parasitic diseases such as malaria, schistosomiasis, and trypanosomiasis. In addition, our research areas include design and synthesis of novel anticancer and antibacterial agents. Furthermore, our efforts are focused on development and optimization of chemical reactions and processes.

Recent Publications:

  1. Vennerstrom, J.L.; Arbe-Barnes, S.; Brun, R.; Charman, S.A.; Chiu, F.C.K.; Chollet, J.; Dong, Y.; Dorn, A.; Hunziker, D.; Matile, H.; McIntosh, K.; Padmanilayam, M.; Santo Tomas, J.; Scheurer, C.; Scorneaux, B.; Tang, Y.; Urwyler, H.; Wittlin, S.; Charman, W.N. Identification of An Antimalarial Synthetic Trioxolane Drug Development Candidate.  Nature 430, pp. 900–904. 2004
  2. Dong, Y.; Chollet, J.: Matile, H.; Charman, S.A.; Chiu, F.C.K.; Charman, W.N.; Scorneaux, B.; Urwyler, H.; Santo Thomas, J.; Scheurer, C.; Snyder, C.; Dorn, A.; Wang, X.; Karle, J.M.; Tang, Y.; Wittlin, S.; Brun, R.; Vennerstrom, J.L.; Spiro and Dispiro-Prototypes. J. Med. Chem., 48, pp. 4953-4961. 2005
  3. Wang, X.; Dong, Y.; Wittlin, S.; Creek, D.; Chollet, J.; Charman, S.A.; Tomas, J.S.; Scheurer, C.; Snyder, C.; Vennerstrom, J.L.; Spiro and Dispiro-1,2-dioxolanes: Contribution of Iron(II)-Mediated One-Electron vs Two-Electron Reduction to the Activity of Antimalarial Peroxides. J. Med. Chem., 50, pp.5840-5847. 2007
  4. Dong, Y.; Wittlin, S.; Sriraghavan, K.; Chollet, J.; Charman, S.A.; Charman, W.N.; Scheurer, C.; Urwyler, H.: Tomas, J.S.; Snyder, C.; Creek, D.J.; Morizzi, J.; Koltun, M.; Matile, H.; Wang, X.; Padmanilayam, M.; Tang, Y,; Dorn, A.; Brun, R.; Vennerstrom, J.L.; The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277). J. Med. Chem., 53, pp. 481-491. 2010
  5. Zhao, Q.; Vargas, M.; Dong, Y.; Zhou, L.; Wang, X.; Sriraghavan, K.; Keiser, J.; Vennerstrom, J.L.; Structure-Activity Relationship of an Ozonide Carboxylic Acid (OZ78) against Fasciola hepatica. J. Med. Chem., 53, pp. 4223-4233. 2010
  6. Nuss, J.E.; Dong, Y.; Wanner, L.M.; Ruthel, G.; Wipf, P.; Gussio, R.; Vennerstrom, J.L.; Bavari, S.; Burnett, J.C.; Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors. ACS Med. Chem. Lett., 1, pp. 301-305. 2010
  7. Charman, S.A.; Arbe-Barnes, S.; Bathurst, I.C.; Brun, R.; Campbell, M.; Charman, W.N.; Chiu, F.C.K.; Chollet, J.; Craft, J.C.; Creek, D.J.; Dong, Y.; Matile, H.; Maurer, M.; Morizzi, J.; Nguyen, T.; Papastogiannidis, P.; Scheurer, C.; Shackleford, D.M.; Sriraghavan, K.; Stingelin, L.; Tang, Y.; Urwyler, H.; Wang, X.; White, K.L.; Wittlin, S.; Zhou, L.; Vennerstrom, J.L.; Synthetic Ozonide drug Candidate (OZ439) Offers New Hope for a Single-dose Cure of Uncomplicated Malaria. PNAS, 108, pp. 4400-4405. 2011