University of Nebraska Medical Center

Corey Hopkins, PhD



Corey Hopkins
Research Activities/Interests
Dr. Hopkins’ primary research interests are related to the design, synthesis and optimization of biologically active small molecules as in vivo probes, drug discovery lead compounds and preclinical candidates. My recent research has focused on designing novel positive allosteric modulators related to numerous CNS-related therapeutic areas. In addition, I have been interested in ion channels for kidney failure, kinase targets for rare and neglected diseases, including pediatric cancers and ion channels for insecticide resistant mosquitos relating to malaria and Zika. Initial work here at UNMC will focus on developing novel chemical probes as: TRPC5 ion channel antagonists that protects the kidney filter, G protein-coupled inwardly-rectifying potassium channel (GIRK) activators as novel anxiolytics, novel Dopamine receptor 4 antagonists for L-DOPA-induced dyskinesia and addiction, and inhibitors of the AeKir1 ion channel that cause kidney failure in mosquitoes that carry malaria, West Nile virus, dengue and yellow fever and Zika.
Teaching Activities
Dr. Hopkins lectures in Medicinal Chemistry and Drug Discovery.