Corey Hopkins, Ph.D.

Associate ProfessorDr. Hopkins

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-9729 (Office)
402-559-5673(Fax)
Email
Curriculum Vitae
Lab website

Teaching Activities:
Dr. Hopkins lectures in Medicinal Chemistry and Drug Discovery.

Research Activities/Interests:  
Dr. Hopkins’ primary research interests are related to the design, synthesis and optimization of biologically active small molecules as in vivo probes, drug discovery lead compounds and preclinical candidates.  My recent research has focused on designing novel positive allosteric modulators related to numerous CNS-related therapeutic areas.  In addition, I have been interested in ion channels for kidney failure, kinase targets for rare and neglected diseases, including pediatric cancers and ion channels for insecticide resistant mosquitos relating to malaria and Zika.  Initial work here at UNMC will focus on developing novel chemical probes as: TRPC5 ion channel antagonists that protects the kidney filter, G protein-coupled inwardly-rectifying potassium channel (GIRK) activators as novel anxiolytics, novel Dopamine receptor 4 antagonists for L-DOPA-induced dyskinesia and addiction, and inhibitors of the AeKir1 ion channel that cause kidney failure in mosquitoes that carry malaria, West Nile virus, dengue and yellow fever and Zika.

Recent Publications:

  1. Engers, D. W.; Blobaum, A. L.; Gogliotti, R. D.; Cheung, Y.-Y.; Salovich, J. M.; Garcia-Barrantes, P. M.; Daniels, J. S.; Morrison, R.; Jones, C. K.; Soars, M. G.; Zhuo, X.; Hurley, J.; Macor, J. E.; Bronson, J. J.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.*, “Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4)”, ACS Chem. Neurosci. 2016, May 3 [Epub ahead of print]. PMID: 27075300.
  2. Gogliotti, R. D.; Blobaum, A. L.; Morrison, R. M.; Daniels, J. S.; Salovich, J. M.; Cheung, Y.-Y.; Rodriguez, A. L.; Loch, M. T.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.*, “Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)”, Bioorg. Med. Chem. Lett. 2016, 26, 2984-2987. PMID: 27234146.
  3. Witt, J. O.; McCollum, A. L.; Hurtado, M. A.; Huseman, E. D.; Jeffries, D. E.; Temple, K. J.; Plumley, H. C.; Blobaum, A. L.; Lindsley, C. W.; Hopkins, C. R.*, “Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists” Bioorg. Med. Chem. Lett. 2016, 26, 2481-2488. PMID: 27080176.
  4. Berry, C. B.; Bubser, M.; Jones, C. K.; Hayes, J. P.; Wepy, J. A.; Locuson, C. W.; Daniels, J. S.; Lindsley, C. W.; Hopkins, C. R.*, “Discovery and characterization of ML398, a potent and selective chiral morpholine-based antagonist of the dopamine 4 (D4) receptor with in vivo activity in a cocaine-induced hyperlocomotion assay”, ACS Med. Chem. Lett. 2014, 5, 1060-1064. PMID: 25221667.
  5. Hover, L. D.; Owens, P.; Munden, A.; Chambless, L.; Hong, C. C.; Hopkins, C. R.; Moses, H. L.; Abel, T. W. “Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma”, Neuro Oncol. 2016, 18, 928-938. PMID: 26683138.
  6. Klar, R.; Walker, A. G.; Ghose, D. Grueter, B. A.; Engers, D. W.; Hopkins, C. R.; Lindsley, C. W.; Xiang, Z.; Conn, P. J.; Niswender, C. M., “Activation of metabotropic glutamate receptor 7 is required for induction of long term potentiation at SC-CA1 synapses in the hippocampus”, J. Neurosci. 2015, 35, 7600-7615. PMID: 25972184.
  7. Wen, W.; Wang, Y.; McManus, O. B.; Wu, M.; Li, M.; Lindsley, C. W.; Dong, X.; Hopkins, C. R.*, “Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1”, Chem. Med. Chem. 2015, 10, 57-61. PMID: 25209672.
  8. Raphemot, R.; Rouhier, M. F.; Swale, D. R.; Days, E.; Weaver, C. D.; Lovell, K. M.; Konkel, L. C.; Engers, D. W.; Bollinger, S. R.; Hopkins, C. R.; Piermarini, P. M.; Denton, J. S., “Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels”, PLoS One 2014, 9, e110772.
  9. Swale, D.; Kurata, H.; Kharade, S.; Sheehan, J.; Raphemot, R.; Voigtritter, K.; Figueroa, E.; Meiler, J.; Blobaum, A.; Lindsley, C.; Hopkins, C. R.*; Denton, J. S.*, “ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels”, ACS Chem. Neurosci. 2016, May 24 [Epub ahead of print]. PMID: 27184474.
  10. Schaldecker, T.; Kim, S.; Tarabanis, C.; Tian, D.; Hakroush, S.; Castonguay, P.; Ahn, W.; Wallentin, H.; Heid, H.; Hopkins, C. R.; Lindsley, C. W.; Riccio, A.; Buvall, L.; Weins, A.; Greka, A.*, “TRPC5 inhibition protects against kidney filter damage”, J. Clin. Invest. 2013, 123, 5298-5309. PMID: 24231357.