David Oupicky, PhD

David Oupicky, PhD

Professor and Parke-Davis Chair in Pharmaceutics

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Buffett Cancer Center
Room 5.12.391
986849 Nebraska Medical Center
Omaha, NE 68198-6849
402-559-9363 (Office)
402-559-9365 (Fax)

Research Activities/Interests:
Dr. Oupicky's research is in the broad area of nanomedicine with emphasis on the development of novel approaches to the design of polymeric drugs and methods of drug combination delivery to better treat various diseases. Current research focus is on the design of multifunctional nanoparticles and polymers with applications in the treatment of metastatic cancer, inflammatory bowel disease, and acute kidney injury.

Recent Publications:

  1. L. Ding, S. Tang, W. Tang, D. D. Mosley, A. Yu, D. Sil, S. Romanova, K. L Bailey, D. L. Knoell, T. A. Wyatt, D. Oupický. Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis. Adv. Science, 2022, 9, 2103676
  2. L. Ding, S. Tang, A. Yu, A. Wang, W. Tang, H. Jia, D. Oupický. Nanoemulsion-assisted siRNA delivery to modulate the nervous tumor microenvironment in the treatment of pancreatic cancer. ACS Appl. Mater. Interfaces, 2022, 14, 8, 10015-10029
  3. W. Tang, Y. Chen, H. Jang, Y. Hang, C. M. Jogdeo, J. Li, L. Ding, C. Zhang, A. Yu, F. Yu, K. W. Foster, B. J. Padanilam, D. Oupický. Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury. J. Controlled Rel., 2021, 341, 300-313
  4. Y. Hang, S. Tang, W. Tang, D. Vetvicka, C. Zhang, Y. Xie, F. Yu, A. Yu, D. Sil, J. Li, R. K. Singh, D. Oupický. Polycation Fluorination Improves Intraperitoneal siRNA Delivery in Metastatic Pancreatic Cancer. J. Controlled Rel., 2021, 333, 139-150
  5. Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano2020, 14, 255-271