David Oupicky, Ph.D.
David Oupicky, Ph.D.

Professor and Center for Drug Delivery and Nanomedicine, Co-Director

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center I
First Floor, Room 1009
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-9363 (Office)
402-559-9365 (Fax)

Research Activities/Interests:
Dr. Oupicky's research is in the broad area of nanomedicine with emphasis on the development of novel approaches to the design of polymeric drugs and methods of drug combination delivery to better treat various diseases. Current research focus is on the design of multifunctional nanoparticles and polymers with applications in the treatment of metastatic cancer, inflammatory bowel disease, and acute kidney injury.

Please visit the Oupicky Lab website and/or the CDDN website for more information.

Recent Publications:

  1. L. Sleightholm, B. K. Neilsen, J. Li, M. M. Steele, R. K. Singh, M. A. Hollingsworth, D. Oupicky. Emerging Roles of the CXCL12/CXCR4 Axis in Pancreatic Cancer Progression and Therapy. Pharmacol. Therap., 2017, 179, 158-170
  2. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238
  3. Chen, K. Wang, Q. Hu, L. Ding, F. Yu, Z. Zhou, Y. Zhou, J. Li, M. Sun, D. Oupicky. Combining fluorination and bioreducibility for improved siRNA polyplex delivery. ACS Appl. Mater. Interfaces, 2017, 9, 4457-4466
  4. Xie, T. Murray-Stewart, Y. Wang, F. Yu, J. Li, L. J. Marton, R. A. Casero, D. Oupicky. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. J. Controlled Rel., 2017, 246, 110-119.
  5. Yu, J. Li, R. L. Sleightholm, Y. Xie, D. Oupicky. Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. J. Controlled Rel., 2016, 244, 347-356.
  6. Wang, S. Kumar, S. Rachagani, B. R. Sajja, Y. Xie, Y. Hang, M. Jain, J. Li, M. D. Boska, S. K. Batra, D. Oupicky. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials, 2016, 101, 108-120.
  7. Yu, Y. Xie, Y. Wang, Z. Peng, J. Li, D. Oupicky. Chloroquine-containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis. ACS Macro Lett., 2016, 5, 342-345.
  8. Xie, C. Wehrkamp, J. Li, Y. Wang. Y. Wang, J. Mott, D. Oupicky. Delivery of miR-200c mimic with poly(amido amine) CXCR4 antagonists for combined inhibition of cholangiocarcinoma cell invasiveness. Mol. Pharmaceutics, 2016, 13, 1073-1080.
  9. Li, F. Yu, Y. Chen, D. Oupicky. Polymeric drugs: Advances in the development of pharmacologically active polymers. J. Controlled Rel., 2015, 219, 369-382.
  10. Wang, S. Hazeldine, J. Li, D. Oupicky. Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids.. Adv. Healthc. Mater., 2015, 4(5), 729-738.