David Oupicky, Ph.D.
David Oupicky, Ph.D.

Professor and Center for Drug Delivery and Nanomedicine, Co-Director

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center I
First Floor, Room 1009
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-9363 (Office)
402-559-9365 (Fax)

Research Activities/Interests:
Dr. Oupicky's research is in the broad area of nanomedicine with emphasis on the development of novel approaches to deliver drug combinations to better treat various diseases. Current research focus is on the design of multifunctional nanoparticles with applications in the treatment of metastatic cancer and inflammatory conditions like Crohn's disease.

Please visit the Oupicky Lab website and/or the CDDN website for more information.

Recent Publications:

  1. Y. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238
  2. G. Chen, K. Wang, Q. Hu, L. Ding, F. Yu, Z. Zhou, Y. Zhou, J. Li, M. Sun, D. Oupicky. Combining fluorination and bioreducibility for improved siRNA polyplex delivery. ACS Appl. Mater. Interfaces, 2017, 9, 4457-4466
  3. Y. Xie, T. Murray-Stewart, Y. Wang, F. Yu, J. Li, L. J. Marton, R. A. Casero, D. Oupicky. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. J. Controlled Rel., 2017, 246, 110-119
  4. F. Yu, J. Li, R. L. Sleightholm, Y. Xie, D. Oupicky. Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. J. Controlled Rel., 2016, 244, 347-356
  5. Y. Wang, S. Kumar, S. Rachagani, B. R. Sajja, Y. Xie, Y. Hang, M. Jain, J. Li, M. D. Boska, S. K. Batra, D. Oupicky. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials, 2016, 101, 108-120
  6. F. Yu, Y. Xie, Y. Wang, Z. Peng, J. Li, D. Oupicky. Chloroquine-containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis. ACS Macro Lett., 2016, 5, 342-345
  7. Y. Wang, S. Hazeldine, J. Li, D. Oupicky. Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids.. Adv. Healthc. Mater., 2015, 4(5), 729-738