David Oupicky, PhD

David Oupicky, PhD

Professor and Parke-Davis Chair in Pharmaceutics

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Buffett Cancer Center
Room 5.12.391
986849 Nebraska Medical Center
Omaha, NE 68198-6849
402-559-9363 (Office)
402-559-9365 (Fax)

Research Activities/Interests:
Dr. Oupicky's research is in the broad area of nanomedicine with emphasis on the development of novel approaches to the design of polymeric drugs and methods of drug combination delivery to better treat various diseases. Current research focus is on the design of multifunctional nanoparticles and polymers with applications in the treatment of metastatic cancer, inflammatory bowel disease, and acute kidney injury.

Please visit the Oupicky Lab website and/or the CDDN website for more information.

Recent Publications:

  1. Y. Xie, Y. Hang, Y. Wang, R. Sleightholm, D. R. Prajapati, J. Bader, A. Yu, W. Tang, L. Jaramillo, J. Li, R. K. Singh, D. Oupicky. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano, 2020, 14, 255-271
  2. Y. Wang, Y. Xie, K. V. Kilchrist, J. Li, C. L. Duvall, D. Oupicky. Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Appl. Mater. Interfaces, 2020, 12, 4308-4322
  3. F. Yu, Y. Wang, Y. Hang, W. Tang, Z. Zhao, D. Oupicky. Synthesis and Biological Characterization of Clicked Chloroquine Copolymers as Macromolecular Inhibitors of Cancer Cell Migration. J. Pol. Sci. A, 2019, 57, 2235-2242
  4. Y. Chen, W. Tang, F. Yu, Y. Xie, L. Jaramillo, H. S. Jang, J. Li, B. J. Padanilam, D. Oupicky. Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury. Int. J. Pharm., 2019, 568, 118555
  5. S. Kanvinde, Y. S. Chhonker, R. Ahmad, F. Yu, R. Sleightholm, W. Tang, L. Jaramillo, Y. Chen, Y. Sheinin, J. Li, D. J. Murry, A. B. Singh, D. Oupicky. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomater., 2018, 82, 158-170
  6. Y. Xie, Y. Wang, J. Li, Y. Hang, L. Jaramillo, C. J. Wehrkamp, M. A. Phillippi, A. M. Mohr, Y. Chen, G. A. Talmon, J. L. Mott, D. Oupicky. Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness. Theranostics, 2018, 8, 4305-4320
  7. R. L. Sleightholm, B. K. Neilsen, J. Li, M. M. Steele, R. K. Singh, M. A. Hollingsworth, D. Oupicky. Emerging Roles of the CXCL12/CXCR4 Axis in Pancreatic Cancer Progression and Therapy. Pharmacol. Therap., 2017, 179, 158-170
  8. Y. Wang, Y. Xie, J. Li, Z. Peng, Y. Sheinin, J. Zhou, D. Oupicky. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano, 2017, 11, 2227-2238
  9. Y. Xie, T. Murray-Stewart, Y. Wang, F. Yu, J. Li, L. J. Marton, R. A. Casero, D. Oupicky. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. J. Controlled Rel., 2017, 246, 110-119.
  10. F. Yu, J. Li, R. L. Sleightholm, Y. Xie, D. Oupicky. Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. J. Controlled Rel., 2016, 244, 347-356
  11. Y. Wang, S. Kumar, S. Rachagani, B. R. Sajja, Y. Xie, Y. Hang, M. Jain, J. Li, M. D. Boska, S. K. Batra, D. Oupicky. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. Biomaterials, 2016, 101, 108-120