Jonathan L. Vennerstrom, PhD

Jonathan L. Vennerstrom, PhD


Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-5362 (Office)
402-559-5673 (Fax)

Teaching Activities:
Dr. Vennerstrom lectures in Medicinal Chemistry I and Medicinal Chemistry II where he is course coordinator. At the graduate level, Dr. Vennerstrom is the course coordinator for Advanced Medicinal Chemistry.

Research Activities/Interests:
The research activity of Dr. Vennerstrom’s laboratory is focused on antiparasitic drug discovery, particularly antimalarial drug design and synthesis and the investigation of heme as a mechanistic intersection for antimalarial drugs. Current projects include drug discovery for schistosomiasis, cytomegalovirus, and tuberculosis.

Recent Publications:

  1. Charman, S. A.; Arbe-Barnes, S.; Bathurst, I. C.; Brun, R.; Campbell, M.; Charman, W. N.; Chiu, F. C. K.; Chollet, J.; Craft, C. J.; Creek, D. J.; Dong, Y.; Matile, H.; Maurer, M.; Morizzi, J.; Nguyen, T.; Papastogiannidis, P.; Scheurer, C.; Shackleford, D. M.; Sriraghavan, K.; Stingelin, L.; Tang, Y.; Urwyler, H.; Wang, X.; White, K. L.; Wittlin, S.; Zhou, L.; Vennerstrom, J. L. Synthetic Ozonide Drug Candidate OZ439 Offers New Hope for a Single-dose Cure of Uncomplicated Malaria. Proc. Natl. Acad. Sci.  2011, 108, 4400–4405.
  2. Keiser, J.; Ingram, K.; Vargas, M.; Chollet, J.; Wang, X.; Dong, Y.; Vennerstrom, J. L. In Vivo Activity of Aryl Ozonides against Schistosoma Species.  Antimicrob. Agents Chemother.  2012, 56, 1090–1092.
  3. Sabbah, D.; Vennerstrom, J. L.; Zhong, H. Binding Selectivity Studies of Phosphoinositide 3-Kinases Using Free Energy Calculations. J. Chem. Inf. Model.  2012, 52, 3213–3224.
  4. Wang, X.; Dong, Y.; Wittlin, S.; Charman, S.; Chiu, F.; Chollet, J.; Katneni, K.; Mannila, J.; Morizzi, J.; Ryan, E.; Scheurer, C.; Steuten, J.; Santo Tomas, J.; Snyder, C.; Vennerstrom, J. L. Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439 and their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres. J. Med. Chem.  2013, 56, 2547−2555.
  5. Wang, X.; Dong, Y.; Cal, M.; Kaiser, M.; Wittlin, S.; Vennerstrom, J. L. Antiprotozoal Selectivity of Diimidazoline N-phenylbenzamides. ACS Infect. Dis. 2015, 1, 135–139.
  6. Jourdan, J.; Matile, H.; Reift, E.; Biehlmaier, O.; Dong, Y.; Wang, X.; Mäser, P.; Vennerstrom, J. L.; Wittlin, S. Monoclonal Antibodies that Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). ACS Infect. Dis. 2016, 2, 54–61.
  7. Wang, C.; Zhao, Q.; Vargas, M.; Jones, J. O.; White, K. L.; Shackleford, D. M.; Chen, G.; Saunders, J.; Ng, A. C. F.; Chiu, F. C. K.; Dong, Y.; Charman, S. A.; Keiser, J.; Vennerstrom, J. L. Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978). J. Med. Chem. 2016, 59, 10705–10718.
  8. Dong, Y.; Wang, X.; Kamaraj, S.; Bulbule, V. J.; Chiu, F. C. K.; Chollet, J.; Dhanasekaran, M.; Hein, C. D.; Papastogiannidis, P.; Morizzi, J.; Shackleford, D. M.; Barker, H.; Ryan, E.; Scheurer, C.; Tang, Y.; Zhao, Q.; Zhou, L.; White, K. L.; Urwyler, H.; Charman, W. N.; Matile, H.; Wittlin, S.; Charman, S. A.; Vennerstrom, J. L. SAR of the Antimalarial Ozonide Artefenomel (OZ439). J. Med. Chem. 2017, 60, 2654–2668.
  9. Wang, X.; Dong, Y.; Ezell, E. L.; Garrison, J. C.; Wood, J. K.; Hagen, J. P.; Vennerstrom, J. L. Semipinacol and Protoadamantane-adamantane Rearrangements of 5,6-Dibromoadamantan-2-one and -2-ol. Tetrahedron 2017, 73, 2972–2976.
  10. Leas, D.; Dong, Y.; Vennerstrom, J. L.; Stack, D. E. One-pot, Metal-free Conversion of Anilines to Aryl Bromides and Iodides. Org. Lett. 2017, 19, 2518–2521.