Dong Wang, Ph.D.
Dong Wang, Ph.D.

Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-1995 (Office)
402-559-1323 (Lab)
402-559-5673 (Fax)
Email

Teaching Activities:
Dr. Wang lectures in Introduction to Pharmaceutical Sciences (PHSC550) and Pharmaceutical Sciences I (PHSC570) in the professional program. At graduate level, he teaches in the Quantitative Pharmaceutical Sciences (PHSC845), Physical Pharmacy (PHSC885) and Nanoimaging and Bioimaging (PHSC848). In addition, he coordinates and teaches in Innovative Drug Delivery Systems (PHSC 851) and Pharmaceutical Chemistry for Drug Delivery and Nanomedicine (PHSC 852)

Research Activities/Interests:

  1. Macromolecular therapies for inflammatory diseases.
  2. Dentrotropic therapies for oral and craniofacial diseases.
  3. Targeted therapies for musculoskeletal diseases.
  4. Click chemistry for drug delivery and nanomedicine.
  5. Biocompatible polymers for biomedical applications.
  6. Prodrug design.

Recent Publications:

  1. Wei, X.; Li, F.; Zhao, G.; Chhonker, Y. S.; Purdue, P. E.; Wang, X. Y.; Fehringer, E. V.; Garvin, K. L.; Goldring, S. R.; Alnouti, Y.; Wang, D. Pharmacokinetic and biodistribution studies of HPMA copolymer conjugates in aseptic implant loosening mouse model. Molecular Pharmaceutics. 2017 Mar 25. doi: 10.1021/acs.molpharmaceut.7b00045. [Epub ahead of print]. PMID: 28343392
  2. Jia, Z. S.; Zhang, Y. J.; Dusad, A.; Ren, K.; Yuan, H. J.; Li, F.; Purdue, P. E.; Fehringer, E. V.; Goldring, S. R.; Daluiski, A.; Wang, D. Simvastatin prodrug micelles target fracture and improve healing. Journal of Controlled Release. 2015, 200, 23–34. PMID: 25542644.
  3. Ren, K.; Yuan, H. J.; Zhang, Y. J.; Wei, X.; Wang, D. Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis. Clinical Immunology. 2015 160, 71–81. PMID: 25869296.
  4. Quan, L. D.; Zhang, Y. J.; Crielaard, B. J.; Dusad, A.; Lele, S. M.; Rijcken, C. J. F. Etrych, T.; Ulbrich, K.; Kiessling, F; Mikuls, T. R.; Hennink, W. E.; Storm, G.; Lammers, T.; Wang, D. Nanomedicines for Inflammatory Arthritis: Head-To-Head Comparison of Glucocorticoid-Containing Polymers, Micelles and Liposomes. ACS Nano. 2014, 8, 458-466. PMID: 24341611.
  5. Ren, K.; Dusad, A.; Yuan, F.; Yuan, H. J.; Purdue, P. E.; Fehringer, E. V.; Goldring, S. R.; Wang, D. Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects. Journal of Controlled Release. 2014, 175, 1–9. PMID: 24326124.
  6. Chen, F.; Jia, Z. S.; Rice, K. C.; Reinhardt, R. A.; Bayles, K. W.; Wang, D. The development of dentotropic micelles with biodegradable tooth-binding moieties. Pharmaceutical Research. 2013, 30, 2808-2817. PMID: 23765401.
  7. Yuan, Y.; Nelson, R. K.; Tabor, D.; Zhang, Y. J.; Akhter, M. P.; Gould, K. A.; Wang, D. Dexamethasone Prodrug Treatment Prevents Nephritis in Lupus-prone (NZB×NZW)F1 Mice without Causing Systemic Side Effects. Arthritis and Rheumatism. 2012, 64, 4029-4039. PMID: 22886616.
  8. Yuan, F.; Quan, L. D.; Cui, L.; Goldring, S. R. and Wang, D. Development of Macromolecular Prodrug for Rheumatoid Arthritis. Advanced Drug Delivery Review. 2012, 64, 1205–1219. PMID: 22433784.
  9. Hein, C. D.; Liu, X. M. and Wang, D. Click Chemistry, a Powerful Tool for Pharmaceutical Sciences. Pharmaceutical Research, 2008, 25, 2216-2230. PMID: 18509602.
  10. Wang, D.; Miller, S. C.; Kopečková, P.; Kopeček, J., Bone-Targeting Macromolecular Therapeutics, Advanced Drug Delivery Reviews, 2005, 57, 1049-1076. PMID: 15876403.