Dong Wang, PhD

Dong-Wang.jpg

Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-1995 (Office)
402-559-1323 (Lab)
402-559-5673 (Fax)
Email
Website

Teaching Activities:
Dr. Wang lectures in Introduction to Pharmaceutical Sciences (PHSC550) and Pharmaceutical Sciences I (PHSC570) in the professional program. At graduate level, he teaches in the Quantitative Pharmaceutical Sciences (PHSC845), Physical Pharmacy (PHSC885) and Nanoimaging and Bioimaging (PHSC848). In addition, he coordinates and teaches in Innovative Drug Delivery Systems (PHSC 851) and Pharmaceutical Chemistry for Drug Delivery and Nanomedicine (PHSC 852)

Research Activities/Interests:

  1. Macromolecular therapies for inflammatory diseases.
  2. Dentrotropic therapies for oral and craniofacial diseases.
  3. Targeted therapies for musculoskeletal diseases.
  4. Click chemistry for drug delivery and nanomedicine.
  5. Biocompatible polymers for biomedical applications.
  6. Prodrug design.

Recent Publications:

  1. Chen, N. R.; Ren, R. G.; Wei, X.; Mukundan, R.; Li, G. J.; Xu, X. K.; Zhao, G.; Zhao, Z.; Lele, S. M.; Reinhardt, R. A.; Wang, D. Thermoresponsive Hydrogel-based Local Delivery of Simvastatin for the Treatment of Periodontitis. Molecular Pharmaceutics. 2021, 18: 1992–2003. PMID: 33754729.
  2. Zhao, Z. F.; Jia, Z. S.; Foster, K. W.; Wei, X.; Qiao, F. F.; Jiang, H. C.; Jin, Y.; Li, G. J.; Chen, N. R.; Zhao, G.; Thiele, G. M.; Medlin, J. L.; O’Dell, J. R.; Wang, D. Glucocorticoid Prodrug (ZSJ-0228) Treatment Significantly Reduces Lupus Nephritis in Mice without Measurable Side Effects - A 5-Month Study. Nanomedicine: Nanotechnology, Biology and Medicine. 2021, 31:102302. PMID: 32980548.
  3. Almoshari, Y.; Ren, R. G.; Zhang, H. P.; Ryu, S. J.; Lele, S. M.; Reinhardt, R. A.; Wang, D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigate periodontal tissue damage associated with experimental periodontitis. Biomaterials. 2020, 261:120293. PMID: 32877763.
  4. Wei, X.; Zhao, G.; Wang, X. B.; Zhao, Z. F.; Gautam, N.; Jia, Z. S.; Kong, D. X.; Zhang, F.; Kumar, S.; Sun, Y. Y.; Chen, N. R.; Wang, X. Y.; Yang, L. B.; Ren, R. G.; Thiele, G. M.; Bronich, T. K.; O’Dell, J. R.; Alnouti, Y.; Wang, D. Head-to-head Comparative Pharmacokinetic and Biodistribution (PK/BD) Study of Two Dexamethasone Prodrug Nanomedicines on Lupus-prone NZB/W F1 Mice. Nanomedicine: Nanotechnology, Biology and Medicine. 2020, 29:102266. PMID: 32679269.
  5. Jia, Z. S.; Wei, X.; Zhao, G.; Kong, D. X.; Sun, Y. Y.; Zhou, Y.; Lele, S. M.; Goldring, S. R.; Wang, D. Structural Optimization of HPMA Copolymer-dexamethasone Conjugates (P-Dex) for Improved Treatment of Inflammatory Arthritis. Journal of Controlled Release, 2020, 324:560-573. PMID: 32445658.
  6. Zhao, G.; Wei, X.; Wu, J. B.; Eichele, D. D.; Lele, S. M.; Yang, L. B.; Zhang, F.; Wang, D. A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice. Pharmaceutical Research. 2019, 36(4):64. doi: 10.1007/s11095-019-2587-6. PMID:30859327
  7. Weber, L; Wang, X. B.; Ren, R. G.; Wei, X.; Yang, J. X.; Yuan, H. J.; Pang, H. L.; Wang, H. J.; Wang, D. The Development of a Macromolecular Analgesic for Arthritis Pain. Mol Pharm. 2019, 16(3):1234-1244. PMID: 30702897
  8. Liu, Y. Z.; Jia, Z. S.; Akhter, M.; Gao, X.; Wang, X. Y.; Wang, X. B.; Zhao, G.; Wei, X.; Zhou, Y.; Wang, X. L.; Hartman, C. W.; Fehringer, E. V.; Cui, L.; Wang, D. Bone-targeting Liposome Formulation of Salvianic Acid A Accelerates the Healing of Delayed Fracture Union in Mice. Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14: 2271-2282.
  9. Wei, X.; Wu, J. B.; Zhao, G.; Galdamez, J.; Lele, S. M.; Wang, X. Y.; Liu, Y. Z.; Soni, D. M.; Purdue, P. E.; Goldring, S. R.; Wang, D. Development of a Janus Kinase (JAK) Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis. Molecular Pharmaceutics. 2018, 15:3456-3467. PMID: 29966420.
  10. Jia, Z. S. ; Wang, X. B. ; Wei, X.; Zhao, G.; Foster, K. W.; Gautam, N.; Yu, F.; Yuan, F.; Gao, Y. Y.; Alnouti, Y.; Thiele, G. M.; O’Dell, J. R.; Wang, D. Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-prone Mice without Apparent Glucocorticoid Side Effects. ACS Nano. 2018, 12:7663-7681. PMID: 29965725