Xiaofang Wang, Ph.D.

Research Assistant ProfessorDr. Wang

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-4635 (Lab)
402-559-5673 (Fax)
Email

Teaching Activities:
Dr. Wang is currently pursuing teaching opportunities in the areas of Medicinal Chemistry and Organic Chemistry.

Research Activities/Interests:
Dr. Wang is involved in core malaria and schistosomiasis research projects, in addition to collaborative projects ranging from botulinum neurotoxins (BoNTs), creatine esters, glucose transporter inhibitors, toxoplasmosis to other tropical diseases studies.

Recent Publications:

  1. Wang, X.; Dong, Y.; Ezell, E. L.; Wood, J. K.; Hagen, J. P. and Vennerstrom, J. L. Semipinacol and protoadamantane-adamantane rearrangements of of 5,6-dibromoadamantane-2-one and 2-ol. Journal of Organic Chemistry, In preparation
  2. Wang, X.; Dong, Y.; Cal, M.; Kaiser, M.; Wittlin, S.; Vennerstrom, J. L. Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides. ACS Infectious Diseases 2015, 1(3), 135-139
  3. Dong, Y.; Wang, X.; Cal, M.; Kaiser, M.; Vennerstrom, J. L. Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & Medicinal Chemistry Letters 2014, 24(3), 944-948
  4. Xue J.; Wang X.; Dong Y.; Vennerstrom J. L; Xiao S.-H. Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice. Parasitology Research 2014, 113(9), 3259-66.
  5. Kuster, T.; Kriegel, N.; Stadelmann, B.; Wang, X.; Dong, Y.; Vennerstrom, J. L.; Keiser, J.; Hemphill, A. Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International Journal of Antimicrobial Agents 2014, 43(1), 40-46
  6. Wang, C.; Zhao, Q.; Min, J.; Muniyan, S.; Vargas, M.; Wang, X.; Dong, Y.; Guy, R. K.; Lin, M.-F.; Keiser, J.; Vennerstrom, J. L. Short report: antischistosomal versus antiandrogenic properties of aryl hydantoin Ro13-3978. American Journal of Tropical Medicine and Hygiene 2014, 90(6), 1156-1158
  7. Wang, X.; Dong, Y.; Wittlin, S.; Creek D.; Charman, S. A.; Chiu, F.; Chollet, J.; Katneni, K.; Mannila, J.; Morizzi, J.; Ryan, E.; Scheurer, C.; Steuten, J.; Tomas, J. S.; Snyder, C.; Vennerstrom, J. L. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439 and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of Medicinal Chemistry 2013, 56(6), 2547-2555
  8. Keiser, J.; Ingram, K.; Vargas, M.; Chollet, J.; Wang, X.; Dong, Y.; Vennerstrom, J. L. In vivo activity of aryl ozonides against Schistosoma species Antimicrobial Agents and Chemotherapy 2012, 56(2), 1090-1092.
  9. Wang, X.; Zhao, Q.; Vargas, M.; Dong, Y.; Sriraghavan, K.; Keiser, J.; Vennerstrom, J. L. The Activity of Dispiro Peroxides Against Fasciola hepatica. Bioorganic & Medicinal Chemistry Letters 2011, 21, 5320–5323
  10. Charman, S.; Arbe-Barnes, S.; Bathurst, I.; Brun, R.; Campbell, M.; Charman, W.; Chiu, F.; Chollet, J.; Craft, J.; Creek, D.; Dong, Y.; Matile, H.; Maurer, M.; Morizzi, J.; Nguyen, T.; Papastogiannidis, P.; Scheurer, C.; Shackleford, D.; Sriraghavan, K.; Stingelin, L.; Tang, Y.; Urwyler, H.; Wang, X.; White, K.; Wittlin, S.; Zhou, L.; Vennerstrom, J. L. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. PNAS 2011, 108(11), 4400-4405