Chair and Professor
Department of Pharmacy Practice and Science
College of Pharmacy
University of Nebraska Medical Center
986145 Nebraska Medical Center
Omaha, NE 68198-6145
Dr. Knoell’s focus of study is to better understand the pathogenesis of lung disease that in turn will reveal new biological insight to prevent or mitigate disease. His laboratory first revealed that zinc and its metabolism, through a family of proteins known as zinc transporters, is critical in preventing lung injury and maintaining host defense against infection. Most recently this line of investigation has focused on zinc metabolism in cell, animal and human studies that has revealed novel insight into zinc coordination over innate immune function through molecular control of integral signaling pathways that impact lung function. Collectively, the major body of this work has resulted in numerous publications in leading journals, continuous NIH-supported research as a PI for over 15 years, international engagement, and several noteworthy awards.
- Knoell DL., Julian MW., Bao S., Besecker B., Huff JE., Leikauf G., DiSilvestro R., Crouser E. Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Critical Care Medicine. 2009:37(4);1380-1388.
- Bao SY, Lui MJ, Lee B, Besecker B, Lai JP, Guttridge D, and Knoell DL. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kB. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2010:298;L744-54.
- Besecker B., Exline M., Hollyfield J, Phillips G, Disilvestro RA, Wewers MD., Knoell DL. A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. American Journal of Clinical Nutrition. 2011:93(6);1356-64.
- Mihai C, Bao SY, Lai JP, Ghadiali S, Knoell DL. PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration. Am J Physiol Lung Cell Mol Physiol. 2012 Feb;302(3):L287-99.
- Napolitano J, Liu MJ, Bao S, Crawford M, Nana-Sinkam P, Cormet-Boyaka E, Knoell DL. Cadmium-related toxicity of lung epithelia is enhanced through NF-kB-mediated transcriptional activation of the human zinc transporter ZIP8. Am J Physiol Lung Cell Mol Physiol. 2012 May 302(9):L909-18.
- Liu MJ, Bao SY, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Nebert DN, Wewers MD, and Knoell DL. ZIP8 regulates host defense through zinc-mediated inhibition of NF-kB.. Cell Reports. 2013. S2211-1247. 10.1016/j.celrep.2013.01.009.
- Liu M, Bao S, Bolin ER, Burris DL, Xu X., Sun Q, Killilea E, Shen Q, Ziouzenkova O, Belury MA, Failla M. Knoell DL. Zinc deficiency exacerbates visceral adipose inflammation in mice fed a high-fat diet. J of Nutrition. 2013 143(7): 1036-45.
- Liu M, Bao S, Napolitano J, Burris D, Yu L, Tridandapani S, Knoell DL. Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PLOS One. 2014 9(4):394934.
- Scordo J, Knoell DL, Torrelles JB. Alveolar epithelial cells in Mycobacterium tuberculosis infection: Active players or innocent bystanders. Journal of Innate Immunity. 2016;8(1):3-14.
- Napolitano J, Rahman MA, Bao S, Liu M, Smith S, and Knoell DL. Cadmium attenuates the macrophage response to LPS through inhibition of the NF-κB pathway. Ameri J Physio Lung Cell Mol Biol. In Press doi:10.1152ajplung.ooo22.2016