University of Nebraska Medical Center

Cancer Biology Program

This program represents a long-standing commitment to cancer mechanisms-focused research.

The vision of the program is to understand the fundamental mechanisms that underlie cancer initiation and progression and to interface with other Eppley programs – including the Targets, Modulators and Delivery Program, and the Gastrointestinal Cancer Program – that are positioned to translate these findings into new biomarkers and therapeutic targets, thereby positively impacting diagnosis, prevention, and treatment across cancers prevalent in our catchment area.


Elizabeth Bruce Professor of Cancer Research, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Director of the Center for Breast Cancer Research
Research focus: Molecular Control of Tyrosine Kinase Signaling: Cell Biology and translation


Hamid Band

Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Research focus: Cell proliferation; prostate and pancreatic cancer


Jixin Dong

Themes and Goals

The Cancer Biology Program is organized into three themes and goals:

  1. Genome instability and cancer
    • Discover alterations of molecular mechanisms that maintain intact genomes.
  2. Signaling mechanisms in cancer
    • Discover alterations in intracellular signaling and tumor cell-microenvironment interactions.
  3. Cellular basis of cancer
    • Using in vitro and animal models, validate cancer mechanisms, biomarkers and targets.