Cancer Biology Program
This program represents a long-standing commitment to cancer mechanisms-focused research.
The vision of the program is to understand the fundamental mechanisms that underlie cancer initiation and progression and to interface with other Eppley programs – including the Targets, Modulators and Delivery Program, and the Gastrointestinal Cancer Program – that are positioned to translate these findings into new biomarkers and therapeutic targets, thereby positively impacting diagnosis, prevention, and treatment across cancers prevalent in our catchment area.
Co-Leaders
Elizabeth Bruce Professor of Cancer Research, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Director of the Center for Breast Cancer Research
Research focus: Molecular Control of Tyrosine Kinase Signaling: Cell Biology and translation
Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Research focus: Cell proliferation; prostate and pancreatic cancer
Themes and Goals
The Cancer Biology Program is organized into three themes and goals:
- Genome instability and cancer
- Discover alterations of molecular mechanisms that maintain intact genomes.
- Signaling mechanisms in cancer
- Discover alterations in intracellular signaling and tumor cell-microenvironment interactions.
- Cellular basis of cancer
- Using in vitro and animal models, validate cancer mechanisms, biomarkers and targets.