Thomas G Martin, PhD
Assistant Professor, UNMC Department of Cellular and Integrative Physiology
Thomas G. Martin, PhD is an Assistant Professor in the Department of Cellular & Integrative Physiology at UNMC.
Dr. Martin's lab studies the molecular regulation of cardiac remodeling in healthy conditions, such as exercise, and the pathological condition of heart failure. His research focuses on structural and functional remodeling at the level of cardiac muscle cells (cardiomyocytes). Dr. Martin's research also takes inspiration from extreme cardiac phenotypes observed in animals adapted to unique environments or lifestyles. His lab is interested in translating molecular findings in nature's outliers to inform the development of new therapeutic strategies for tuning human cardiac function.
- BS: Madonna University, 2017
- PhD: Loyola University Chicago, 2021
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Postdoctoral Fellow: University of Colorado Boulder, 2026
Martin TG, Hunt DR, Langer SJ, Tan Y, Ebmeier CC, Leinwand LA. Regression of post-prandial cardiac hypertrophy in Burmese pythons is mediated by FoxO1. Proceedings of the National Academy of Sciences, 2024.
Martin TG*, Hunt DR*, Ebmeier CC, Dhand AP, Alamana C, Cleveland Jr. JC, Graw SL, Bruner S, Bristow MR, Taylor MRG, Mestroni L, Burdick JA, Ambardekar AV, Buttrick PM, Leinwand LA. Myocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D. Circulation, 2026.
Dhand AP*, Juarros MA*, Martin TG*, Garay Sarmiento M, Alamana C, Hunt DR, Rodriguez-Rivera GJ, Obenreder MC, Crosby CO, Meurer Zeman B, McAfee Q, Valle-Ayala H, Zlotnick HM, Goddard DN, Ebmeier CC, Burdick JA, Leinwand LA. Digital light processing 3D printing enables versatile fabrication of human engineered heart tissues. Cell Biomaterials, 2026.
Xiao S*, Wang M*, Martin TG*, Scott B, Fang X, Liu X, Yang Y, Fu S, Truong SD, Li VL, Gugel JF, Maas GL, Mullen M, Hampton Hill J, Li VL, Markhard AL, Zhao M, Qi W, Reghupaty SC, Zhao M, Spaas J, Wei W, Moholdt T, Hawley JA, Voldstedlund CT, Richter EA, Chen X, Svensson KJ, Bernstein D, Leinwand LA, Xu Y, Long JZ. Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway. Nature Metabolism, 2026.
Full list of publications, National Library of Medicine
- Molecular mechanisms of cardiac plasticity
- Cardiomyocyte protein quality control regulation
- Comparative cardiac biology
- Alternative RNA splicing