Kishore Challagundla

Assistant Professor, Biochemistry and Molecular Biology

Kaustubh Datta, PhDPhone: 402-559-9032 (Office)
402-559-3441 (Lab)
Fax: 402-559-6650
kishore.challagundla@unmc.edu 

Education:
Ph.D. (Biochemistry): University of Lucknow, India; 2001-2007
PG Diploma in Nutrition: National Institute of Nutrition, India; 2000
Masters (Biochemistry): Bharathidasan University, India; 1997-1999
Bachelors (Botany, Zoology, Chemistry): Nagarjuna University, India; 1994-1997

Post-Doctoral Training:
Mayo Clinic (Rochester, MN); 2007-2009
Oregon Health & Science University (Portland, OR); 2009-2012
Children’s Hospital Los Angeles (Los Angeles, CA); 2012-2016

 

Research:

Uncontrolled growth, drug resistance, and distant metastasis are the principle causes of mortality among cancer patients. Increasing evidence indicates that communication between cancer cells and other cells of the tumor microenvironment adds fuel to cancer cell survival and disease progression. MicroRNAs (miRNAs) are small noncoding RNAs, whose gene regulatory functions are dysregulated in almost all human cancers.

Although notable advances have been made in treating various types of cancers in the last few decades, curing this disease remains a great challenge. Even though there is a significant research effort in studying the function of non-coding RNAs in cancer biology, the role of tumor-stromal cell interactions and their secretomes in regulating therapy resistance are largely unknown.

The goal of my research program is to investigate the roles of exosomes and non-coding RNAs in inducing immunotherapy resistance, and to develop novel therapeutic strategies and non-coding RNA based biomarkers in pediatric cancers. My group also investigates on the post-translational modifications of immune checkpoint inhibitors by ubiquitination and their potential role in escaping immune surveillance in pediatric cancers.

Research Opportunities in my laboratory:
Currently accepting motivated, fun loving, enthusiastic MD/PhD students, graduate students, summer Fellows, and Postdoctoral Fellows.

Primary Research/Clinical Interests/Expertise:
Pediatric cancers including Neuroblastoma and Acute Myeloid Leukemia
Exosomes and non-coding RNAs in tumor microenvironment
MicroRNA biogenesis mechanism(s)
Post-translational modifications of immune checkpoint inhibitors
Immunotherapy resistance
Identification of biomarkers and developing new therapeutic targets for cancer treatment 

Publications:

Complete List of Published Work

Current Grants:
Funding Institution:     NIH/NCI-K22 Transition Career Development Award
Dates:                          09/01/2016-08/30/2019
Title:                            Exosomic miRNAs and drug resistance in AML tumor microenvironment
Role:                            Principal Investigator
 
Funding Institution:     State of Nebraska - Pediatric Cancer Research Center                   
Dates:                          03/01/2017 – 02/28/2019
Title:                           Targeting exosomic microRNAs-Dicer-MycN axis in Neuroblastoma chemo resistance
Role:                            Principal Investigator
 
Funding Institution: F&PBCC and UNMC Pediatric Cancer Research Group (PCRG)
Dates:                          04/01/2018 – 03/31/2019
Title:                           Regulation of PD-L1 by MYCN in Neuroblastoma
Role:                            Principal Investigator

Funding Institution: Leukemia Research Foundation (LRF)
Dates:                          07/01/2018-06/30/2019
Title:                            Exosomic miRNAs and PD-L1 in AML Therapy Resistance
Role:                            Principal Investigator
 
Completed Grants:
Funding Institution:     LB506, DHHS, Nebraska State                                                                                                                     
Dates:                          07/01/2017 – 06/31/2018
Title:                           Targeted therapy of exosomes and telomerase axis in AML therapy resistance
Role:                            Principal Investigator 

 

Links:

Non-Coding RNA Network:
Gene/miRNA and their targetsmiRBaseTargetScanTranscription Factor-MicroRNA RegulationsUC Base Data MiningPredicting RNA Targets of lncRNAsUltraconserved Non-Coding Elements and Genomic Regulatory BlocksRNAhybrid

Exosome Database:
ExoCarta-Exosome Database
Exosome RNA DatabasesEVpedia - Extracellular Vesicle Database
Vesiclepedia-Extracellular Vesicles Database
exoRBase: Database of circRNA, lncRNA and mRNA

Cancer Datasets Portals:
R2: Genomics Analysis and Visualization PlatformThe Cancer Genome Atlas (TCGA)ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining PlatformNCI Cancer Datasets Portal

Neuroblastoma Key Resources:
Neuroblastoma TARGETTranscriptomic profiling of 39 commonly-used neuroblastoma cell linesChildren’s Oncology Group  

Genomics/Proteomics:
Ensembl Genome Browser  
UCSC Genome Browser NCBI (Entrez) (OMIM)
Catalogue Of Somatic Mutations In Cancer (COSMIC)cBioPortal for Cancer GenomicsUniProt: The Universal Protein Knowledgebase
SWISS-PROT 
STRING: Protein Association Network
BioGRID | Database of Protein, Chemical, and Genetic InteractionsIntAct database - EMBL-EBIProtein Blast NCBI

NIH Resources:
NIH Grant Cycle & Due Dates
NIH Career Development Programs   
NIH resources for new investigators
NIH Current RFAs & PQs
NIH RePORTER search tool (formerly the CRISP database)  
Grantome:The Entirety Of Funding Information