Imayavaramban Lakshmanan

Assistant Professor, Biochemistry and Molecular Biology

Phone: 402-559-7754 (Lab)Imay-profile-photos.jpg
Fax: 402-559-6650
email

Education:

Ph.D., University of Madras, Tamil Nadu, India

Research Interest: Molecular mechanism(s) of lung cancer metastasis

Research:

Overall goal of our group is to identify the molecular mechanism of MUC5AC (secretory type) and MUC16 and MUC4 (transmembrane type) in promoting lung cancer metastasis. During cancer cells transformation, progression and metastasis, mucins and their associated oncogenic signals are unified to safeguard cancer cells against controlled growth and apoptosis. Mucins are heavily glycosylated proteins found to be overexpressed in several cancers and are implicated in progression, metastasis, and resistance to therapy. Therefore, we are focusing to investigate the mucin-mediated molecular mechanisms that drive the cancer cells towards proliferation and metastatic process.

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To understand the molecular mechanism behind mucins dependent pathogenesis, we are employing various novel approach using 3D in vitro tumoroid and mouse models.  MUC16 and MUC5AC are overexpressed in specific subtypes of lung and breast cancers and demonstrated that these mucins are strongly associated with cancer cell proliferation and metastasis (as shown in Figure 1 and 2). Currently, we are focusing on the oncogenic mutations of Kras and p53 and their ability to disseminate the primary tumor cells towards metastasis-associated phenotype.

Publications:

Complete List of Published Work