Ashley L. Hein, MD

• Fellow, Gastrointestinal and Liver Pathology, Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York City, NY
• Resident, Anatomic and Clinical Pathology, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE; Co-Chief Resident, 2023-2024
• MD, University of Nebraska Medical Center, College of Medicine, Omaha, NE 
• Bachelor of Science, Biology, University of Nebraska at Omaha, Omaha, NE 

• Gastrointestinal Pathology
• Liver Pathology
• Transplant Pathology

Hein AL, Hissong E. Advancements and challenges in biomarker testing for tumors of the luminal gastrointestinal tract: current practice guidelines and emerging markers. Diagnostic Histopathology. 2025 June: 31 (6):340-351. doi: https://doi.org/10.1016/j.mpdhp.2025.03.011. 

Jenkins CB, Camero AL, Graff BT, Madduri LSV, O'Connell KA, Hein AL, Smith LM, Enke CA, Dong J, Hollingsworth MA, Johnson KR, Ouellette MM, Yan Y. PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation. Oncogene. 2025 Jun 26. doi: 10.1038/s41388-025-03477-y. Epub ahead of print. PMID: 40571777. 

Palanivel C, Madduri LSV, Hein AL, Jenkins CB, Graff BT, Camero AL, Zhou S, Enke CA, Ouellette MM, Yan Y. PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation. Aging (Albany NY). 2024 Mar 4;16(5):4116-4137. doi: 10.18632/aging.205619. Epub 2024 Mar 4. PMID: 38441530; PMCID: PMC10968692. 

Hein AL, Singh N, Cohen SM. Small Intestinal Adenocarcinoma Involving a Submucosal Ectopic Lymph Node: A Case Report. Int J Surg Pathol. 2024 Aug;32(5):970-975. doi: 10.1177/10668969231204970. Epub 2023 Oct 19. PMID: 37858929.

Hein AL, Cathcart SJ, Cushman-Vokoun A, Shonka NA, Abromowitch M, Punsoni M, Chen J. Bithalamic and Unithalamic Glioma with EGFR Exon 20 Insertions: A Report of Two Cases and Literature Review. J Neuropathol Exp Neurol. 2022 Oct 18;81(11):943-946. doi: 10.1093/jnen/nlac080. PMID: 36094585.

Rajdev K, Madan U, McMillan S, Wilson K, Fisher K, Hein AL, Patil A, Bista S, Hershberger D, Boer B. Pulmonary Tumor Embolism and Pulmonary Tumor Thrombotic Microangiopathy Causing Rapidly Progressive Respiratory Failure: A Case Series. J Investig Med High Impact Case Rep. 2022 Jan-Dec; 10:23247096221086453. doi: 10.1177/23247096221086453. PMID: 35313765; PMCID: PMC8943465.

Hein AL, Mukherjee M, Talmon GA, Natarajan SK, Nordgren TM, Lyden E, Hanson CK, Cox JL, Santiago-Pintado A, Molani MA, Ormer MV, Thompson M, Thoene M, Akhter A, Anderson-Berry A, Yuil-Valdes AG. QuPath Digital Immunohistochemical Analysis of Placental Tissue. J Pathol Inform. 2021 Nov 1;12:40. doi: 10.4103/jpi.jpi_11_21. PMID: 34881095; PMCID: PMC8609285.

Kanteti AP, Atiya S, Hein AL, Cox JL, Martinez Duarte E. Medullary Thyroid Carcinoma Presenting as Metastatic Disease to the Breast. Case Rep Pathol. 2020 May 22;2020:6138409. doi: 10.1155/2020/6138409. PMID: 32528739; PMCID: PMC7262663.

Hein AL, Yuil-Valdes A. Informatics, digital & computational pathology: Education. Pathology Outlines. Published Apr 30 2020.

Hein AL, Brandquist ND, Ouellette CO, Seshacharyulu P, Enke CA, Ouellette MM, Batra SK, Yan Y. PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and stabilized YAP in pancreatic cancer cells. Oncogenesis. 2019, Oct;8(11):63. PMID: 31659153.

Tian T, Bi C, Hein AL, Zhang X, Wang C, Shen S, Yuan J, Greiner TC, Enke C, Vose J, Yan Y, Fu K. Rac1 is a novel therapeutic target in mantle cell lymphoma. Blood Cancer J. 2018, Feb;8(2):17. PMID: 29434202.

Arnst JL, Hein AL, Taylor MA, Palermo NY, Contreras JI, Sonawane YA, Wahl AO, Ouellette MM, Natarajan A, Yan Y. Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget. 2017, May;8(21):34586–34600. PMID: 28410221.

Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y.  RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016, Dec;35(49):6319–6329. PMID: 27181206.

Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ponnusamy MP, Mumby MC, Ouellette MM, Batra SK, Yan Y. PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling. Cancer Res. 2016, Apr;76(8):2243–2253. PMID: 26893480.   

Yan Y, Hein AL, Greer PM, Wang Z, Kolb RH, Batra SK, Cowan KH. A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation. Oncogene. 2015, Apr;34(17):2215–2226. PMID: 24909175. 

Hein AL, Ouellette MM, Yan Y. Radiation-induced signaling pathways that promote cancer cell survival (Review). Int J Oncol, 2014, Nov;45(5):1813-1819. PMID: 25174607. 

Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM. Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget. 2014, Nov;5(21):10251–10270. PMID: 25344910.

• Resident Service in Graduate Medical Education Award, UNMC, 2024
• Resident Peer Teaching Award, UNMC, 2023
• Outstanding Clinical Pathology Manuscript Award, UNMC, 2022
• Society of ’67 Kinney Scholar, 2021
• Jerald R. Schenken, M.D. Outstanding Achievement in Pathology and Microbiology Award, 2020

• College of American Pathologists
• United States and Canadian Academy of Pathology