Brady Sillman, PhD

Education

PhD in Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 2019
BS in Biology, University of Nebraska Omaha, 2013

Recognition

2020: New Investigator Scholarship; Conference on Retrovirsuses and Opportunistic Infections (CROI) 2020
2019: Best Poster Presentation; 2019 Department of Pharmacology and Experimental Neuroscience Retreat
2018: First Place Oral Presentation: Graduate Student/Resident; 49th Annual Midwest Student Biomedical Research Forum
2017: Oral Presentation to Represent UNMC; 13th International Student Research Forum
2017: First Place Poster Presentation & Graduate College Award: Graduate Student/Resident; 48th Annual Midwest Student Biomedical Research Forum

2016: Excellence in Conference Presentation, Second Place: Bioengineering and Drug Delivery; 2016 American Physician Scientists Association Midwest Regional Meeting
2013: B.S. Awarded with Great Honors (Magna Cum Laude); University of Nebraska at Omaha
2012–2013: Funding for Undergraduate Scholarly Experiences (FUSE) grant; University of Nebraska at Omaha
2012: Biochemistry Award for Excellent Achievements in Science; Chemistry Department – University of Nebraska at Omaha
2009–2013: University of Nebraska at Omaha Alumni Association Scholarship
2009–2013: University of Nebraska at Omaha Chancellor’s Scholarship

Selected Publications

Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE. Creation of a long-acting nanoformulated dolutegravir. Nat Commun. 2018 Feb 6;9(1).
Edagwa B, McMillan J, Sillman B, Gendelman HE. Long-acting slow effective release antiretroviral therapy. Expert Opin Drug Deliv. 2017 Nov;14(11).
Gnanadhas DP, Dash PK, Sillman B, Bade AN, Lin Z, Palandri DL, Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S. Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs. J Clin Invest. 2017 Mar 1;127(3).
McMillan J, Szlachetka A, Slack L, Sillman B, Lamberty B, Morsey B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS. Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques. Antimicrob Agents Chemother. 2017 Dec 21;62(1).
Sillman B, Woldstad C, Mcmillan J, Gendelman HE. Neuropathogenesis of human immunodeficiency virus infection. Handb Clin Neurol. 2018;152.
Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nat Commun. 2019 Jul 2;10(1).
Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Creation of a long-acting rilpivirine prodrug nanoformulation. J Control Release. 2019 Oct;311-312.
Kulkarni TA, Bade AN, Sillman B, Shetty BLD, Wojtkiewicz MS, Gautam N, Hilaire JR, Sravanam S, Szlachetka A, Lamberty BG, Morsey BM, Fox HS, Alnouti Y, McMillan JM, Mosley RL, Meza J, Domanico PL, Yue TY, Moore G, Edagwa BJ, Gendelman HE. A year-long extended release nanoformulated cabotegravir prodrug. Nat Mater. 2020 Aug;19(8).

Gautam N, McMillan JM, Kumar D, Bade AN, Pan Q, Kulkarni TA, Li W, Sillman B, Smith NA, Shetty BLD, Szlachetka A, Edagwa BJ, Gendelman HE, Alnouti Y. Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir. Nat Commun. 2021 Jun 8;12(1).

Su H, Sravanam S, Sillman B, Waight E, Makarov E, Mathews S, Poluektova LY, Gorantla S, Gendelman HE, Dash PK. Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice. J Neuroimmune Pharmacol. 2021 Dec;16(4).