Salma Abdullah Althobaiti, PharmD, MS
PhD Student, Research Assistant

I earned a Doctor of Pharmacy (Pharm.D.) degree from Taif University in Saudi Arabia, where I later served as a teaching assistant in the College of Pharmacy. I went on to pursue my Master of Science in Pharmaceutical Sciences at Wayne State University. My master’s research focused on the development of pH-triggered lipid nanoparticle (LNP) systems for the delivery of CD40 agonist antibodies in pancreatic ductal adenocarcinoma (PDAC), with the goal of enhancing immunotherapeutic efficacy while minimizing systemic toxicity.
Currently, I am pursuing a PhD with a focus on the development of PEGylated Dexamethasone prodrugs (PEG-Dex) for the treatment of focal segmental glomerulosclerosis (FSGS). My research centers on the design and optimization of innovative PEG-Dex prodrugs for the treatment of FSGS. I am actively engaged in the in vivo evaluation of kidney-targeted corticosteroid prodrugs, focusing on enhancing therapeutic efficacy, minimizing systemic toxicity, and elucidating pharmacokinetic/pharmacodynamic (PK/PD) relationships. My research encompasses the development of advanced drug delivery systems, validation of analytical methods, and preclinical assessment of therapeutic performance in relevant animal models. Outside of the lab, I enjoy exploring fashion, taking nature walks, arranging flowers, and horseback riding.