Kaushik P. Patel

Kaushik P. Patel Professor
Ph.D. from University of Western Ontario, London, Ontario, Canada, 1983
Major Interest: Neural control of circulation
Curriculum Vitae

Research in the laboratory is focused on the neural regulation of cardiovascular and renal function in health and disease states.  We are studying various aspects of the blood volume regulation in normal and disease states such as heart failure, diabetes and hypertension.  Biochemical, molecular biology, electrophysiological, hemodynamic and renal function measurements and techniques are used for studying the various components of the blood volume reflex arc with particularly emphasis on role the paraventricular nucleus of the hypothalamus in this regulation.  These studies are providing important new insights about the normal neural regulation of fluid balance and about altered fluid balance and its consequences in various disease states.

Patelfigure

Recent publications:

  1. Sharma NM, Nandi SS, Zheng, H, Mishra PK, and PATEL KP. A novel role for miR-133a in centrally mediated activation of the Renin-angiotensin system in congestive heart failure. Am J Physiol Heart Circ Physiol. 312(5):H968-H979, 2017. PMID:28283551
  2. Zheng, H, and PATEL KP. Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Autonomic Neuroscience: Basic and Clinical S1566-0702(16)30131-X. (Invited Review) 2017. PMID:27527558 PMC 5293680
  3. Sharma NM and PATEL KP. Post-translational Regulation of Neuronal Nitric Oxide Synthase: Implications for sympatho-excitatory states.  Expert Opin. on Ther. Targets 21(1):11-22. 2017 PMID:27885874
  4. Sharma NM, Cunningham CJ, Zheng, H, Liu X and PATEL KP. HIF-1 alpha mediates increased sympthoexcitation via glutamatergic NMDA receptors in the PVN of rats with heart failure. Circulation: Heart Failure. Nov;9(11). 2016 PMID:27810863
  5. Stern JE, Son SJ, Biancardi VC, Zheng H, Sharma NM and PATEL KP. Astrocytes contribute to Angiotensin II stimulatory actions on hypothalamic presympathetic neuronal activity and sympathetic activity. Hypertension 68(6):1483-1493. 2016 PMID:27698069
  6. PATEL KP, Xu B, Liu X, Sharma NM, Zheng, H. Renal denervation improves exaggerated symptho-excitation in rats with heart failure: Role for nNOS in the paraventricular nucleus. Hypertension 68(1):175-84. 2016. PMID:27185748