Kaushik P. Patel

Kaushik P. Patel Professor
Ph.D. from University of Western Ontario, London, Ontario, Canada, 1983
Major Interest: Neural control of circulation
Curriculum Vitae

Research in the laboratory is focused on the neural regulation of cardiovascular and renal function in health and disease states.  We are studying various aspects of the blood volume regulation in normal and disease states such as heart failure, diabetes and hypertension.  Biochemical, molecular biology, electrophysiological, hemodynamic and renal function measurements and techniques are used for studying the various components of the blood volume reflex arc with particularly emphasis on role the paraventricular nucleus of the hypothalamus in this regulation.  These studies are providing important new insights about the normal neural regulation of fluid balance and about altered fluid balance and its consequences in various disease states.

Patelfigure

Recent publications:

  1. PATEL KP, Xu B, Liu X, Sharma NM, Zheng, H. Renal denervation improves exaggerated symptho-excitation in rats with heart failure: Role for nNOS in the paraventricular nucleus. Hypertension 68(1):175-84. 2016. PMID:27185748
  2. Zheng, H, Liu X, Sharma, NM, & PATEL KP. Renal denervation improves cardiac function in rats with heart failure: effects on expression of b-adrenoceptors. Am J Physiol Heart Circ Physiol  (In Press) 2016. PMID:27288440
  3. Mahata SK, Zheng H, Mahata S, Liu X and PATEL KP. Effect of Heart Failure on Catecholamine Granule Morphology and Storage in Chromaffin Cells. J. Endocrinology 230:1-15, 2016. PMID:27402067
  4. Zheng, H, Liu, X, Sharma, NM, Pliquett,RU, & PATEL KP. Urinary proteolytic activation of renal epithelial Na+ channels in chronic heart failure. Hypertension 67:197-205, 2016. PMID:26628676
  5. Xu B, Zheng, H, Liu, X, & PATEL KP. Activation of Afferent Renal Nerves Modulates RVLM Projecting PVN Neurons. Am J Physiol Heart Circ Physiol 308(9):H1103-11, 2015. PMID: 25637549
  6. Zheng, H, Liu, X, Li, YL, and PATEL, KP. Atenuated dopaminergic tone in the paraventricular nucleaus contributing to sympathoexcitation in rats with Type 2 diabetes. Am J Physiol. Regul Integr Comp Physiol. 306(2):R138-48, 2014. PMID:24305061