Ph.D. 1979, University of Illinois
Major Interest: Sensory and motor functions of the autonomic nervous system
Our laboratory is devoted to the study of chemoreflex and baroreflex regulation of cardio-respiratory function in health and exercise and how these reflexes are altered in diseases such as heart failure. Much of our effort is devoted to exploring the cellular and molecular mechanisms of sensory transduction in cardiovascular chemoreceptor and baroreceptor nerves. In particular, we are interested in the characteristics of certain types of mechano- and chemo-sensitive channels identified in these sensory neurons. Members of our lab carry out neurophysiological experiments using a variety of techniques.
- Del Rio R, Andrade DC, Marcus NJ, Schultz HD. Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control. Exp Physiol. 100(2):136-42, 2015. Epub 2014/11/16. PubMed PMID: 25398714.
- Del Rio R, Andrade DC, Toledo C, Diaz HS, Lucero C, Arce-Alvarez A, Marcus NJ, Schultz HD. Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure. Sci Rep. 7(1):8035, 2017. PubMed PMID: 28808320
- Marcus NJ, Del Rio R, Ding Y, Schultz HD. KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure. J Physiol. 2017 Sep 6. [Epub ahead of print] PubMed PMID: 29023738.
- Lewis R, Hackfort BT, Schultz HD. Chronic heart failure abolishes circadian rhythms in resting and chemoreflex breathing. Adv Exp Med Biol. 2018 (in press).