Harold D. Schultz

Harold D. SchultzProfessor
Ph.D. 1979, University of Illinois
Specialty: Neurophysiology
Major Interest: Sensory and motor functions of the autonomic nervous system
Curriculum Vitae

Our laboratory is devoted to the study of chemoreflex and baroreflex regulation of cardio-respiratory function in health and exercise and how these reflexes are altered in diseases such as heart failure. Much of our effort is devoted to exploring the cellular and molecular mechanisms of sensory transduction in cardiovascular chemoreceptor and baroreceptor nerves. In particular, we are interested in the characteristics of certain types of mechano- and chemo-sensitive channels identified in these sensory neurons. Members of our lab carry out neurophysiological experiments using a variety of techniques.
Figure A

Recent publications:

  1. Schultz HD, Marcus NJ, Del Rio R. Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies. Adv Exp Med Biol. 2015;860:167-85. doi: 10.1007/978-3-319-18440-1_19. Review. PubMed PMID:26303479.
  2. Marcus NJ, Pügge C, Mediratta J, Schiller AM, Del Rio R, Zucker IH, Schultz HD. Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure. Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H259-66. doi: 10.1152/ajpheart.00268.2015. Epub 2015 May 22. PubMed PMID: 26001414
  3. Zucker IH, Schultz HD, Patel KP, Wang H. Modulation of angiotensin II signaling following exercise training in heart failure. Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H781-91. doi: 10.1152/ajpheart.00026.2015. Epub 2015 Feb 13. Review. PubMed PMID: 25681422
  4. Marcus NJ, Del Rio R, Schultz HD. Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure. Front Physiol. 2014 Nov 24;5:438. doi: 10.3389/fphys.2014.00438. eCollection 2014. PubMed PMID: 25505417
  5. Del Rio R, Andrade DC, Marcus NJ, Schultz HD. Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control. Exp Physiol. 2015 Feb 1;100(2):136-42. doi: 10.1113/expphysiol.2014.079566. Epub 2015 Jan 6. Review. PubMed PMID: 25398714
  6. Schultz HD, Marcus NJ, Del Rio R. Mechanisms of carotid body chemoreflex dysfunction during heart failure. Exp Physiol. 2015 Feb 1;100(2):124-9. doi:10.1113/expphysiol.2014.079517. Epub 2015 Jan 15. Review. PubMed PMID: 25398713