Irving H. Zucker
Irving H. Zucker

Theodore F. Hubbard Professor of Cardiovascular Research and Chair
Ph.D. 1972, New York Medical College
Specialty: Cardiovascular physiology
Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress
Lab page
Curriculum Vitae

Our research focuses on the role of the central brain mechanisms on neurohormonal adjustments in cardiovascular regulation in the setting of experimental chronic heart failure. We are interested in the role of substances such as angiotensin II, ACE2, nitric oxide and reactive oxidant stress as important mediators of sympathetic excitation in the setting of chronic heart failure. Molecular, cellular and whole animal techniques are used to understand abnormal cardiovascular and neural regulation in heart failure. In addition, we are extremely interested in the role of exercise training in ameliorating some of the abnormalities we have found in the central nervous system of animals with heart failure.

A secondary interest relates to the role of cardiac sympathetic sensory endings in mediating sympatho-excitation and cardiac remodeling in heart failure and hypertension.

These techniques are providing important new information about normal cardiovascular physiology and about the pathophysiology of heart failure and other cardiovascular diseases.

Students in this laboratory learn surgical preparation of chronically instrumented animals and techniques for measuring a variety of cardiovascular parameters in awake, chronically instrumented animals. Molecular biological techniques such as Western blots, real time RT PCR and histological techniques are routinely used.

Zucker figures

Recent Publications

  1. Gao L, Zimmerman MC, Biswal S, Zucker IH.  Selective Nrf2 Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice. Hypertension. 2017 Jun; 69(6):1198-1206. doi: 10.1161/HYPERTENSIONAHA.117.09123. Epub 2017 May 1. PMID: 28461605
  2. Becker BK, Wang H, Zucker IH.  Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats. Auton Neurosci. 2017 Jul; 205:77-86. doi: 10.1016/j.autneu.2017.05.009. Epub 2017 May 19. PMID: 28549782
  3. Tian C, Gao L, Zimmerman MC, Zucker IH. Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure. Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H928-H939. doi: 10.1152/ajpheart.00602.2017. Epub 2018 Jan 26. PMID: 29373037
  4. Wang HJ, Rozanski GJ, Zucker, IH. Cardiac sympathetic afferent reflex control of cardiac function in normal and chronic heart failure states.

    J Physiol. 2017 Apr 15;595(8):2519-2534. doi: 10.1113/JP273764. Epub 2017 Feb 27. PMID: 2811751

  5. de Morais SDB, Shanks J, Zucker, IH. Integrative Physiological Aspects of Brain RAS in Hypertension. Curr Hypertens Rep. 2018 Feb 26;20(2):10. doi: 10.1007/s11906-018-0810-1. Review. PMID: 29480460