Irving H. Zucker
Irving H. Zucker

Theodore F. Hubbard Professor of Cardiovascular Research and Chair
Ph.D. 1972, New York Medical College
Specialty: Cardiovascular physiology
Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress
Lab page
Curriculum Vitae

Our research focuses on the role of the central brain mechanisms on neurohormonal adjustments in cardiovascular regulation in the setting of experimental chronic heart failure. We are interested in the role of substances such as angiotensin II, ACE2, nitric oxide and reactive oxidant stress as important mediators of sympathetic excitation in the setting of chronic heart failure. Molecular, cellular and whole animal techniques are used to understand abnormal cardiovascular and neural regulation in heart failure. In addition, we are extremely interested in the role of exercise training in ameliorating some of the abnormalities we have found in the central nervous system of animals with heart failure.

A secondary interest relates to the role of cardiac sympathetic sensory endings in mediating sympatho-excitation and cardiac remodeling in heart failure and hypertension.

These techniques are providing important new information about normal cardiovascular physiology and about the pathophysiology of heart failure and other cardiovascular diseases.

Students in this laboratory learn surgical preparation of chronically instrumented animals and techniques for measuring a variety of cardiovascular parameters in awake, chronically instrumented animals. Molecular biological techniques such as Western blots, real time RT PCR and histological techniques are routinely used.

Zucker figures

Recent Publications

  1. Wang, H-J., Cahoon, R., Cahoon, E.B., Zheng, H., Patel, K. P., Zucker I.H.  Glutamatergic Receptor Dysfunction in Spinal Cord Contributes to the Exaggerated Exercise Pressor Reflex in Heart Failure. Am. J. Physiology: Heart and Circulatory Physiology. 77:H447-H455, 2015. PMID: 25502111          
  2. Pügge, C., Mediratta, J., Marcus, N.J., Schultz, H.D., Zucker, I.H. Exercise training normalizes renal blood flow responses to acute stress in experimental heart failure: Role of the α1-adrenergic receptor. J. Appl. Physiol. 120: 334-343, 2016. PMID: 26607245.
  3. Becker, B.K., Zucker, I.H., Wang, H-J. Influence of Brain-Derived Neurotrophic Factor-TrkB Signaling in the NTS on Baroreflex Sensitivity in Rats with Chronic Heart Failure. J. Physiol. 2016, In Press.
  4. Schiller, A. M., Pellegrino, P.R., Zucker, I.H. The renal nerves decrease renal blood flow variability by buffering the renal circulation from arterial pressure oscillations in conscious rabbits. Am J Physiol: Regulatory, Integrative and Comparative Physiology. 310:R156-166, 2016 PMID: 26538235
  5. Ardell, J.L., Andresen, M., Armour, J.D., Billman, G., Chen, P.S., Foreman, R., Herring, N.,  O'Leary, D., Sabbah, H, Schultz, H.D., Sunagawa, K., Zucker, I.H. Translational Neurocardiology: preclinical models and cardioneural integrative aspects. J. Physiol. (epub ahead of print, April 21, 2016). PMID: 27098459