University of Nebraska Medical Center

Irving H. Zucker, PhD

Theodore F. Hubbard Professor of Cardiovascular Research
Professor, UNMC Department of Cellular and Integrative Physiology


Irving H. Zucker, PhD

Irving H. Zucker, PhD, is the Theodore F. Hubbard Professor of Cardiovascular Research in the UNMC Department of Cellular and Integrative Physiology. He served as department chair from 1989-2019.

Dr. Zucker received his PhD from New York Medical College in 1972. He continued his postdoctoral training at UNMC, where he became a faculty member in 1973.

Dr. Zucker has been involved in studies related to the neural regulation of cardiovascular function over his career. His studies have revolved around cardiovascular reflex control of sympathetic nerve activity in animal models of chronic heart failure. These investigations focus on the role of central mediators of sympathetic nerve activity such as angiotensin II, nitric oxide, exercise training, extracellular vesicular communication, Nrf2 and oxidative stress.

Dr. Zucker has published approximately 300 papers in this field and this work has been continuously funded by the National Institutes of Health, the American Heart Association and industry. He has been the recipient of a MERIT Award from the National Heart, Lung and Blood Institute, an established investigator of the American Heart Association, the Wiggers Award from the Cardiovascular Section of the American Physiological Society, as well as the Carl Ludwig Award from the Neural Control and Autonomic Regulation Section of the American Physiological Society. In 1993, he received the Outstanding Research and Creative Activity Award from the University of Nebraska.

He serves on multiple editorial boards. He was a member of the National Research Committee of the American Heart Association. He was editor-in-chief of the American Journal of Physiology: Heart and Circulatory Physiology from 2013-2020. He is a past-president of the Association of Chairs of Departments of Physiology and a past-president of the American Physiological Society.

  • Bachelor's:  City College of New York, New York, biology, 1965
  • Master's: University of Missouri at Kansas City, biology, 1967
  • PhD: New York (N.Y.) Medical College, physiology, 1972
  • Postdoctoral: University of Nebraska Medical Center, physiology, 1972-73
  • Sympathetic regulation in heart failure and hypertension.
  • Oxidative stress, antioxidant proteins, exercise, extracellular vesicle communication.
Honors and Service
  • Past president, American Physiological Society, 2009.
  • Editor-in-chief, American Journal of Physiology-Heart and Circulatory Physiology, 2013-2020.