Irving H. Zucker
Irving H. Zucker

Theodore F. Hubbard Professor of Cardiovascular Research and Chair
Ph.D. 1972, New York Medical College
Specialty: Cardiovascular physiology
Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress
Lab page
Curriculum Vitae

Our research focuses on the role of the central brain mechanisms on neurohormonal adjustments in cardiovascular regulation in the setting of experimental chronic heart failure. We are interested in the role of substances such as angiotensin II, ACE2, nitric oxide and reactive oxidant stress as important mediators of sympathetic excitation in the setting of chronic heart failure. Molecular, cellular and whole animal techniques are used to understand abnormal cardiovascular and neural regulation in heart failure. In addition, we are extremely interested in the role of exercise training in ameliorating some of the abnormalities we have found in the central nervous system of animals with heart failure.

A secondary interest relates to the role of cardiac sympathetic sensory endings in mediating sympatho-excitation and cardiac remodeling in heart failure and hypertension.

These techniques are providing important new information about normal cardiovascular physiology and about the pathophysiology of heart failure and other cardiovascular diseases.

Students in this laboratory learn surgical preparation of chronically instrumented animals and techniques for measuring a variety of cardiovascular parameters in awake, chronically instrumented animals. Molecular biological techniques such as Western blots, real time RT PCR and histological techniques are routinely used.

Zucker figures

Recent Publications

  1. Becker BK, Wang H, Zucker IH.  Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats. Auton Neurosci. 2017 Jul; 205:77-86. doi: 10.1016/j.autneu.2017.05.009. Epub 2017 May 19. PMID: 28549782
  2. Gao L, Zimmerman MC, Biswal S, Zucker IH.  Selective Nrf2 Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice. Hypertension. 2017 Jun; 69(6):1198-1206. doi: 10.1161/HYPERTENSIONAHA.117.09123. Epub 2017 May 1. PMID: 28461605
  3. Wang HJ, Rozanski GJ, Zucker IH. Cardiac sympathetic afferent reflex control of cardiac function in normal and chronic heart failure states. J Physiol. 2017 Apr 15; 595(8):2519-2534. doi: 10.1113/JP273764. Epub 2017 Feb 27. PMID: 28116751
  4. Schiller, AM, Pellegrino, PR, Zucker, IH. The renal nerves decrease renal blood flow variability by buffering the renal circulation from arterial pressure oscillations in conscious rabbits. Am J Physiol: Regulatory, Integrative and Comparative Physiology. 310:R156-166, 2016 PMID: 26538235
  5. Ardell, JL, Andresen, M, Armour, JD, Billman, G, Chen, PS, Foreman, R, Herring, N,  O'Leary, D, Sabbah, H, Schultz, HD, Sunagawa, K, Zucker, IH. Translational Neurocardiology: preclinical models and cardioneural integrative aspects. J. Physiol. 2016 Jul 15; 594(14):3877-909. doi: 10.1113/JP271869. Epub 2016 Jun 17.  PMID: 27098459