Angela Hewlett, MD, MS

George W. Orr MD and Linda Orr Chair in Health Security
Professor, UNMC Division of Infectious Diseases
Medical Director, Orthopedic Infectious Diseases Service and Nebraska Biocontainment Unit

Phone: 402-559-8650
Fax: 402-559-5581

Angela Hewlett MD, MS, is Professor of Internal Medicine and Infectious Diseases at the University of Nebraska Medical Center (UNMC) and the University of Nebraska College of Public Health. She is the George W. Orr and Linda Orr Chair in Health Security.

Dr. Hewlett serves as Medical Director of the Nebraska Biocontainment Unit and Associate Medical Director of the National Quarantine Unit, where she actively participated in the care of several patients with Ebola virus disease as well as some of the first patients in the United States with COVID-19.  She has provided subject matter expertise through the National Emerging Special Pathogens Training and Education Center (NETEC) and multiple other national and international biopreparedness advisory groups and venues.

Dr. Hewlett is an active clinician, and served as Director of the Orthopedic Infectious Diseases team at UNMC from 2009-2025. She collaborates with colleagues in Orthopedic Surgery, ID pharmacy, and others to provide the highest standard of inpatient and outpatient care for patients with complicated bone and joint infections, utilizing an integrated multidisciplinary approach. She is a past-President of the Musculoskeletal Infection Society (MSIS) and was an invited delegate at the International Consensus Meeting (ICM) on Periprosthetic Joint Infection in 2018 and 2025.

Dr. Hewlett enjoys her role as a clinician-educator. She is the Director of the UNMC School of Medicine Enhanced Medical Education Track (EMET) in Biopreparedness and Biocontainment and also coordinates biocontainment training for UNMC ID Fellows. Her research interests include investigational therapeutic agents for emerging infectious diseases, biopreparedness and complicated bone and joint infections. She has authored more than 130 publications and book chapters. Her textbook ‘Planning for Bioemergencies: A Guide for Healthcare Facilities’ was released in 2018. 

Dr. Hewlett earned a BA in Biology from the University of Texas at Austin, and an MD from the University of Texas Medical Branch (UTMB) in Galveston, Texas, where she also completed a residency in Internal Medicine. She served as Chief Resident, then completed a two-year fellowship in Infectious Diseases followed by a one-year NIH-funded research fellowship with a focus in Hospital Epidemiology and Infection Control.  She also holds a Master’s degree in Clinical Sciences-Clinical Investigation from the University of Texas Medical Branch.