Jian Xie, PhD
Assistant Professor, UNMC Department of Pathology, Microbiology and Immunology
Jian Xie, PhD, is an assistant professor in the UNMC Department of Pathology, Microbiology and Immunology. During his graduate training at Rensselaer Polytechnic Institute from 2011-15, Dr. Xie primarily focused on intracellular membrane trafficking in cancer signaling.
As a postdoc from 2015 and later as an associate research scientist on the faculty of Yale School of Medicine, his research focused on virus-host interactions, especially in cancer-related viruses.
At UNMC, he is associated with the doctoral programs of biochemistry and molecular biology; bioinformatics and systems biology; molecular genetics & cell biology; and the Immunology, Pathology & Infectious Disease Graduate Program.
The overarching goal of Dr. Xie’s research at UNMC is to define the membrane-associated virus-host interactions in infection and innate immunity at the molecular level.
- BSc: Department of Virology, College of Life Science, Wuhan University, China, 1997.
- MSc: Department of Microbiology, College of Life Science, Wuhan University, China, 2001.
- PhD: Biochemistry and Biophysics Graduate Program, Rensselaer Polytechnic Institute, Troy, New York, 2015.
- Postdoctoral Associate: Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, Conn., 2020.
- Associate Research Scientist: Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT, 2022.
- Virus-host interactions.
- RNA functions.
- Membrane trafficking.
- Membrane contact sites.
- Liquid-liquid phase separation.
- Intracellular delivery.
Invention: Jian Xie, Daniel DiMaio. Inhibitors of Cellular Deubiquitinases as Anti-Viral Agents, Applying through Yale Ventures.
- Shannon Faris, Ke Xia, Andrew G. Wagner, Zihan Xu, Brian Callahan, and Jian Xie*, Chunyu Wang*. Conserved C143 Forms a Branched Intermediate in Hedgehog Autoprocessing: A New Cancer Drug Discovery Target Against Hedgehog Signaling. Proc. Natl. Acad. Sci, Minor revision.* Co-corresponding authors.
- Jian Xie, Pengwei Zhang, Mac Crite, Christina Lindsay, Daniel DiMaio. Retromer Stabilizes Transient Membrane Insertion of L2 Capsid Protein during Retrograde HPV entry. Sci. Adv., 2021, 7: eabh4276.
- Jian Xie, Erin Heim, Mac Crite, Daniel DiMaio. TBC1D5-Catalyzed Cycling of Rab7 is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. Cell Rep., 2020, 31: 107750.
- American Society for Virology.
- American Society for Cell Biology.
- American Association for the Advance of Science.
- American Chemical Society.
- Associate editor, Virology Journal.
- Guest editor, Pathogens, Special Issue: "Membrane-Associated Virus-Host Interaction in Infetion and Innate Immunity."
- Editorial board member, Pathology and Laboratory Medicine.
- Guest editor, JoVE, section on Human Papillomavirus Entry mechanism.
- Referee, Viruses, Vaccines, Viorlogy Journal, Journal of Theorectical Biology, American Chemical Society publications.