University of Nebraska Medical Center

Shilpa Buch, PhD

  • PhD, University of Baroda, India, 1982
  • MS in Microbiology, University of Baroda, India, 1979
  • Society on NeuroImmune Pharmacology
  • International Society of Neurovirology
  • International Society for Extracellular Vesicles
  • Nebraska Center for Substance Abuse Research
  • Indian Academy of Neurosciences
  • American Society for Exosomes and Microvesicles
  • American Association for Extracellular Vesicles
  • International Brain Research Organization
  • International Drug & Alcohol Research Society
  • American Society Intercellular Communication
  • Distinguished Services Award - Society on NeuroImmune Pharmacology (2023)
  • Herman Friedman Founders Award - Society on NeuroImmune Pharmacology (2017)
  • Community Pride of Nebraska Professor of Neuroscience (2016)
  • International Society of Neurovirology WIN (Women in Neuroscience) Award (2016)
  • Strategies to develop the Nebraska Center for Substance Abuse Research (2016-Present)
  • Graduated from the ELAM Program (2015-2016)
  • Scientist Laureate, UNMC (2015)
  • Distinguished Services Award - Society on NeuroImmune Pharmacology (2013)
  • Wybran Award - Society on NeuroImmune Pharmacology (2012)
  • Distinguished Scientist Award at UNMC (2011)
  • Research Investigator Award at UNMC (2008)
  • K-INBRE Faculty Scholar Award (2005)
Selected Publications
  • Kannan M, Sil S, Oladapo A, Thangaraj A, Periyasamy P, Buch S. HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis. Redox Biol. 2023;62:102689. PubMed PMID: 37023693; PMCID: PMC10106521.
  • Chemparathy DT, Sil S, Callen S, Chand HS, Sopori M, Wyatt TA, Acharya A, Byrareddy SN, Fox HS, Buch S. Inflammation-Associated Lung Tissue Remodeling and Fibrosis in Morphine-Dependent SIV-Infected Macaques. Am J Pathol. 2023;193(4):380-91. PubMed PMID: 37003622; PMCID: PMC10116601.
  • Chivero ET, Thangaraj A, Tripathi A, Periyasamy P, Guo ML, Buch S. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Mol Neurobiol. 2021;58(5):2215-30. PubMed PMID: 33417223; PMCID: PMC8026688.
  • Thangaraj A, Chivero ET, Tripathi A, Singh S, Niu F, Guo ML, Pillai P, Periyasamy P, Buch S. HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress. Redox Biol. 2021;40:101843. PubMed PMID: 33385630; PMCID: PMC7779826.
  • Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis. PLoS Biol. 2020;18(5):e3000660. PubMed PMID: 32453744; PMCID: PMC7274476.
  • Liao K, Niu F, Hu G, Yang L, Dallon B, Villarreal D, Buch S. Morphine-mediated release of miR-138 in astrocyte-derived extracellular vesicles promotes microglial activation. J Extracell Vesicles. 2020;10(1):e12027. PubMed PMID: 33304479; PMCID: PMC7710131.
  • Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S. Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. J Cell Biol. 2019;218(2):700-21. PubMed PMID: 30626719; PMCID: PMC6363463.
  • Periyasamy P, Thangaraj A, Guo ML, Hu G, Callen S, Buch S. Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci. 2018;38(23):5367-83. PubMed PMID: 29760177; PMCID: PMC5990983.
  • Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016;215(2):245-58. PubMed PMID: 27810915; PMCID: PMC5084649.
  • Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K, Fu M, Hu G, Kolattukudy P, Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun. 2014;5:4386. PubMed PMID: 25019481; PMCID: PMC4104446.