University of Nebraska Medical Center

Guoku Hu, PhD

My research interests center around neurodegenerative diseases, specifically substance use disorders,  Alzheimer's disease, and Parkinson's disease, with a unique emphasis on understanding the roles of extracellular vesicles (EVs) and primary cilia in these pathologies.

  • PhD in Genetics, Sichuan University, Chengdu, China, 2006
Research Interests

neurodegenerative diseases, substance use disorders,  Alzheimer's disease, and Parkinson's disease, extracellular vesicles (EVs) primary cilia.

Selected Publications
  • Ma R*, Kutchy NA, Wang Z, Hu G*. Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain. Molecular Therapy. 2023 May 3;31(5):1332-1345. doi: 10.1016/j.ymthe.2023.03.030. Epub 2023 Apr 3. PMID: 37012704.
  • Ma R, Kutchy NA, Hu G*.  Astrocyte-Derived Extracellular Vesicle-Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine Tolerance. Biological Psychiatry. 2021 Jun 17:S0006-3223(21)01395-0. doi: 10.1016/j.biopsych.2021.06.009. Online ahead of print. PMID: 34417054.
  • Chivero ET*, Dagur RS, Peeples ES, Sil S, Liao K, Ma R, Chen L, Gurumurthy CB, Buch S, Hu G*. Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. Cellular and Molecular Life Sciences. 2021 Jun;78(11):4849-4865. doi: 10.1007/s00018-021-03824-8. Epub 2021 Apr 5. PMID: 33821293.
  • Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.  PLOS Biology. 2020 May 26;18(5):e3000660. doi: 10.1371/journal.pbio.3000660. eCollection 2020 May. PMID: 32453744.
  • Dagur RS, Liao K, Sil S, Niu F, Sun Z, Lyubchenko YL, Peeples ES, Hu G*, Buch S*. Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Journal of Extracellular Vesicles. 2019 Dec 20;9(1):1703249. doi: 10.1080/20013078.2019.1703249. eCollection 2020. PMID: 32002168.
  • Liao K, Niu F, Dagur RS, He M, Tian C, Hu G*. Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice. Journal of Neuroimmune Pharmacology. 2019 Jul 20. doi: 10.1007/s11481-019-09864-z. PubMed PMID: 31325121.
  • Cao M, Li H, Zhao J*, Cui J*Hu G*. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. Neurobiology of Aging. 2019 Jun 6;81:116-126. doi: 10.1016/j.neurobiolaging. 2019.05.023. [Epub ahead of print] PubMed PMID: 31280115.
  • Hu G*, Liao K, Niu F, Yang L, Dallon BW, Callen S, Tian C, Shu J, Cui J, Sun Z, Lyubchenko YL, Ka M, Chen XM, Buch S*. Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration. Molecular Therapy-Nucleic Acids. 2018 Dec 7;13:450-463. doi: 10.1016/j.omtn.2018.09.019. Epub 2018 Sep 29. PubMed PMID: 30388619; PubMed Central PMCID: PMC6202788.
  • Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. Journal of Immunology. 2016 Mar 15;196(6):2799-2808. doi:10.4049/jimmunol.1502146. Epub 2016 Feb 15. PubMed PMID: 26880762; PubMed Central PMCID: PMC4779692.
  • Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLOS Pathogens. 2013;9(4):e1003261. doi: 10.1371/journal.ppat.1003261. Epub 2013 Apr 4. PubMed PMID: 23592986; PubMed Central PMCID: PMC3617097.