University of Nebraska Medical Center

Guoku Hu, PhD

My long term goal is to elucidate the functional aspects of exosomes and noncoding RNAs in NeuroAIDS and other neurodegenerative diseases and to identify novel therapeutic strategies that may enhance neuronal function and survival in these disorders.

  • PhD in Genetics, Sichuan University, Chengdu, China, 2006
Research Interests

HIV and drug abuse synergy, exosomes, noncoding RNAs

Selected Publications
  • Ma R*, Kutchy NA, Wang Z, Hu G*. Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain. Molecular Therapy. 2023 May 3;31(5):1332-1345. doi: 10.1016/j.ymthe.2023.03.030. Epub 2023 Apr 3. PMID: 37012704.
  • Ma R, Kutchy NA, Hu G*.  Astrocyte-Derived Extracellular Vesicle-Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine Tolerance. Biological Psychiatry. 2021 Jun 17:S0006-3223(21)01395-0. doi: 10.1016/j.biopsych.2021.06.009. Online ahead of print. PMID: 34417054.
  • Chivero ET*, Dagur RS, Peeples ES, Sil S, Liao K, Ma R, Chen L, Gurumurthy CB, Buch S, Hu G*. Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. Cellular and Molecular Life Sciences. 2021 Jun;78(11):4849-4865. doi: 10.1007/s00018-021-03824-8. Epub 2021 Apr 5. PMID: 33821293.
  • Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.  PLOS Biology. 2020 May 26;18(5):e3000660. doi: 10.1371/journal.pbio.3000660. eCollection 2020 May. PMID: 32453744.
  • Dagur RS, Liao K, Sil S, Niu F, Sun Z, Lyubchenko YL, Peeples ES, Hu G*, Buch S*. Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Journal of Extracellular Vesicles. 2019 Dec 20;9(1):1703249. doi: 10.1080/20013078.2019.1703249. eCollection 2020. PMID: 32002168.
  • Liao K, Niu F, Dagur RS, He M, Tian C, Hu G*. Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice. Journal of Neuroimmune Pharmacology. 2019 Jul 20. doi: 10.1007/s11481-019-09864-z. PubMed PMID: 31325121.
  • Cao M, Li H, Zhao J*, Cui J*Hu G*. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. Neurobiology of Aging. 2019 Jun 6;81:116-126. doi: 10.1016/j.neurobiolaging. 2019.05.023. [Epub ahead of print] PubMed PMID: 31280115.
  • Hu G*, Liao K, Niu F, Yang L, Dallon BW, Callen S, Tian C, Shu J, Cui J, Sun Z, Lyubchenko YL, Ka M, Chen XM, Buch S*. Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration. Molecular Therapy-Nucleic Acids. 2018 Dec 7;13:450-463. doi: 10.1016/j.omtn.2018.09.019. Epub 2018 Sep 29. PubMed PMID: 30388619; PubMed Central PMCID: PMC6202788.
  • Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. Journal of Immunology. 2016 Mar 15;196(6):2799-2808. doi:10.4049/jimmunol.1502146. Epub 2016 Feb 15. PubMed PMID: 26880762; PubMed Central PMCID: PMC4779692.
  • Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLOS Pathogens. 2013;9(4):e1003261. doi: 10.1371/journal.ppat.1003261. Epub 2013 Apr 4. PubMed PMID: 23592986; PubMed Central PMCID: PMC3617097.