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Wang Laboratory of Pharmaceutical Chemistry and Nanomedicine
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Publications
2022
Krell, L.; Bertels, M.; Christiansen, M. M.; Anderson, L.; Hattervig, R. L.; Samson, K. K.; Wang, D. ; Reinhardt, R. A.; Killeen, A. C. The Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients: Randomized Clinical Trial. Journal of Periodontology. 2022 . May 27. doi: 10.1002/JPER.21-0708. Online ahead of print. PMID: 35622060.
Zhao, Z. F.; Jiang, H. C.; Xu, X. K.; Jia, Z. S.; Ren, R. G.; Foster, K. W.; Wei, X.; Chen, N. R.; Goldring, S. R.; Crow, M. K.; Wang, D. Polymeric dexamethasone prodrugs attenuate lupus nephritis in MRL/lpr mice with reduced glucocorticoid toxicity. Nanomedicine, NBM. 2022 . Jun 26;102579. doi: 10.1016/j.nano.2022.102579. Online ahead of print. PMID: 35768036.
2021
Zhao Z, Jia Z, Foster KW, Wei X, Qiao F, Jiang H, Jin Y, Li G, Chen N, Zhao G, Thiele GM, Medlin JL, O'Dell JR, Wang D. Dexamethasone prodrug nanomedicine (ZSJ-0228) treatment significantly reduces lupus nephritis in mice without measurable side effects - A 5-month study. Nanomedicine. 2021 Jan 31:102302. doi:10.1016/j.nano.2020.102302. Epub 2020 Sep 24. PMID: 32980548.
Chen, N. R.; Ren, R. G.; Wei, X.; Mukundan, R.; Li, G. J.; Xu, X. K.; Zhao, G.; Zhao, Z.; Lele, S. M.; Reinhardt, R. A.; Wang, D. Thermoresponsive Hydrogel-based Local Delivery of Simvastatin for the Treatment of Periodontitis. Molecular Pharmaceutics. 2021 , 18: 1992–2003. PMID: 33754729.
Hong, J.; Adam, R. J.; Gao, L.; Hahka, T.; Xia, Z. Q.; Wang, D. ; Nicholas, T. A.; Zucker, I. H.; Lisco, S. J.; Wang, H. J. Macrophage Activation in Stellate Ganglia Contributes to Lung Injury-Induced Arrhythmogenesis. Acta Physiologica. 2021 , 232: e13657. PMID: 33817984.
DeKorver, N. W.; Chaudoin, T. R.; Zhao, G.; Wang, D. ; Arikkath, J.; Bonasera, S. J. Complement Protein C3 Loss leads to Locomotor Deficits and Altered Cerebellar Internal Granule Cell In Vitro Synaptic Protein Expression in C57BL/6 mice. Mol Neurobiol. 2021 Aug 20. doi: 10.1007/s12035-021-02480-0. Online ahead of print. PMID: 34415487.
Mikuls, T. R.; Gaurav, R.; Thiele, G. M.; England, G. R.; Wolfe, M. G.; Shaw, B. P.; Bailey, K. L.; Wyatt, T. A.; Nelson, A. J.; Duryee, M. J.; Hunter, C. D.; Wang, D. ; Romberger, D. J.; Ascherman, D. P.; Poole, J. A. The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease. Int Immunopharmacol. 2021 Aug 27;100:108069. doi:10.1016/j.intimp.2021.108069. Online ahead of print. PMID: 34461491.
Zhao, Z. F.; Xu, X. K.; Jiang, H. C.; Foster, K. W.; Jia, Z. S.; Wei, X.; Chen, N. R.; Goldring, S. R.; Crow, M. K.; Wang, D. Preclinical Dose-escalation Study of ZSJ-0228, a Polymeric Dexamethasone Prodrug, in the Treatment of Murine Lupus Nephritis. Molecular Pharmaceutics. 2021, 18:4188-4197. PMID: 34569234.
Zhao, G.; Ren, R. G.; Wei, X.; Chen, N. R.; Sun, Y. Y.; Zhao, Z. F.; Lele, S. M.; Zhong, H. Z. A.; Goldring, M. B.; Goldring, S. R.; Wang, D. Thermoresponsive Polymeric Dexamethasone Prodrug for Arthritis Pain. Journal of Controlled Release. 2021, 339: 484–497. PMID: 34653564.
2020
Almoshari Y, Ren R, Zhang H, Jia Z, Wei X, Chen N, Li G, Ryu S, Lele SM, Reinhardt RA, Wang D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis. Biomaterials. 2020 Dec;261:120293. doi: 10.1016/j.biomaterials.2020.120293. Epub 2020 Aug 21. PubMed PMID: 32877763; PubMed Central PMCID: PMC7541605.
Wei X, Zhao G, Wang X, Gautam N, Jia Z, Zhao Z, Kong D, Zhang F, Kumar S, Sun Y, Chen N, Wang X, Yang L, Ren R, Thiele GM, Bronich TK, O'Dell JR, Alnouti Y, Wang D. Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice. Nanomedicine. 2020 Oct;29:102266. doi: 10.1016/j.nano.2020.102266. Epub 2020 Jul 15. PubMed PMID: 32679269; PubMed Central PMCID: PMC7508892.
Jia Z, Zhao G, Wei X, Kong D, Sun Y, Zhou Y, Lele SM, Fehringer EV, Garvin KL, Goldring SR, Wang D. Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis. J Control Release. 2020 Aug 10;324:560-573. doi: 10.1016/j.jconrel.2020.05.028. Epub 2020 May 20. PubMed PMID: 32445658; PubMed Central PMCID: PMC7429277.
2019
Zhao G, Wei X, Wu J, Eichele DD, Lele SM, Yang L, Zhang F, Wang D. A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Pharm Res. 2019 Mar 11;36(4):64. doi: 10.1007/s11095-019-2587-6. PubMed PMID: 30859327; PubMed Central PMCID: PMC7433013.
Weber L, Wang X, Ren R, Wei X, Zhao G, Yang J, Yuan H, Pang H, Wang H, Wang D. The Development of a Macromolecular Analgesic for Arthritic Pain. Mol Pharm. 2019 Mar 4;16(3):1234-1244. doi: 10.1021/acs.molpharmaceut.8b01197. Epub 2019 Feb 14. PubMed PMID: 30702897; PubMed Central PMCID: PMC6413733.
2018
Nelson AJ, Roy SK, Warren K, Janike K, Thiele GM, Mikuls TR, Romberger DJ, Wang D, Swanson B, Poole JA. Sex differences impact the lung-bone inflammatory response to repetitive inhalant lipopolysaccharide exposures in mice. J Immunotoxicol. 2018 Dec;15(1):73-81. doi: 10.1080/1547691X.2018.1460425. PubMed PMID: 29648480; PubMed Central PMCID: PMC6122601.
Jia Z, Wang X, Wei X, Zhao G, Foster KW, Qiu F, Gao Y, Yuan F, Yu F, Thiele GM, Bronich TK, O'Dell JR, Wang D. Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-Prone Mice without Apparent Glucocorticoid Side Effects. ACS Nano. 2018 Aug 28;12(8):7663-7681. doi: 10.1021/acsnano.8b01249. Epub 2018 Jul 17. PubMed PMID: 29965725; PubMed Central PMCID: PMC6117746.
Wei X, Wu J, Zhao G, Galdamez J, Lele SM, Wang X, Liu Y, Soni DM, Purdue PE, Mikuls TR, Goldring SR, Wang D. Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis. Mol Pharm. 2018 Aug 6;15(8):3456-3467. doi: 10.1021/acs.molpharmaceut.8b00433. Epub 2018 Jul 16. PubMed PMID: 29966420; PubMed Central PMCID: PMC6078779.
Wang X, Jia Z, Almoshari Y, Lele SM, Reinhardt RA, Wang D. Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis. Pharm Res. 2018 Jun 25;35(8):164. doi: 10.1007/s11095-018-2444-z. PubMed PMID: 29943090; PubMed Central PMCID: PMC7424626.
2017
Zimel MN, Horowitz CB, Rajasekhar VK, Christ AB, Wei X, Wu J, Wojnarowicz PM, Wang D, Goldring SR, Purdue PE, Healey JH. HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer. Mol Cancer Ther. 2017 Dec;16(12):2701-2710. doi: 10.1158/1535-7163.MCT-15-0995. Epub 2017 Aug 22. PubMed PMID: 28830983; PubMed Central PMCID: PMC5847372.
Willett ES, Liu J, Berke M, Giannini PJ, Schmid M, Jia Z, Wang X, Wang X, Samson K, Yu F, Wang D, Nawshad A, Reinhardt RA. Standardized Rat Model Testing Effects of Inflammation and Grafting on Extraction Healing. J Periodontol. 2017 Aug;88(8):799-807. doi: 10.1902/jop.2017.160771. Epub 2017 Apr 25. PubMed PMID: 28440741.
Wei X, Li F, Zhao G, Chhonker YS, Averill C, Galdamez J, Purdue PE, Wang X, Fehringer EV, Garvin KL, Goldring SR, Alnouti Y, Wang D.Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model. Mol Pharm. 2017 May 1;14(5):1418-1428. doi: 10.1021/acs.molpharmaceut.7b00045. Epub 2017 Apr 5. PubMed PMID: 28343392; PubMed Central PMCID: PMC5906048.
Zhang D, Wang D, Pipinos II, Muelleman RL, Li YL. Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia-reperfusion. Acta Physiol (Oxf). 2017 Feb;219(2):453-464. doi: 10.1111/apha.12737. Epub 2016 Jul 5. PubMed PMID: 27306588.
Wells A, Romberger DJ, Thiele GM, Wyatt TA, Staab E, Heires AJ, Klassen LW, Duryee MJ, Mikuls TR, Dusad A, West WW, Wang D, Poole JA. Systemic IL-6 Effector Response in Mediating Systemic Bone Loss Following Inhalation of Organic Dust. J Interferon Cytokine Res. 2017 Jan;37(1):9-19. doi: 10.1089/jir.2016.0048. Epub 2016 Nov 22. PubMed PMID: 27875664; PubMed Central PMCID: PMC5240004.
2016
Zhang Y, Jia Z, Yuan H, Dusad A, Ren K, Wei X, Fehringer EV, Purdue PE, Daluiski A, Goldring SR, Wang D. The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model. Pharm Res. 2016 Aug;33(8):1959-71. doi: 10.1007/s11095-016-1932-2. Epub 2016 May 10. PubMed PMID: 27164897; PubMed Central PMCID: PMC4945391.
Staab E, Thiele GM, Clarey D, Wyatt TA, Romberger DJ, Wells AD, Dusad A, Wang D, Klassen LW, Mikuls TR, Duryee MJ, Poole JA. Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss. PLoS One. 2016;11(8):e0158735. doi: 10.1371/journal.pone.0158735. eCollection 2016. PubMed PMID: 27479208; PubMed Central PMCID: PMC4968800.
Bradley AD, Zhang Y, Jia Z, Zhao G, Wang X, Pranke L, Schmid MJ, Wang D, Reinhardt RA. Effect of Simvastatin Prodrug on Experimental Periodontitis. J Periodontol. 2016 May;87(5):577-82. doi: 10.1902/jop.2016.150599. Epub 2016 Jan 22. PubMed PMID: 26799395.
Quan L, Zhang Y, Dusad A, Ren K, Purdue PE, Goldring SR, Wang D. The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model. Pharm Res. 2016 Jan;33(1):186-93. doi: 10.1007/s11095-015-1776-1. Epub 2015 Aug 19. PubMed PMID: 26286188; PubMed Central PMCID: PMC4690754.
2015
Poole JA, Romberger DJ, Wyatt TA, Staab E, VanDeGraaff J, Thiele GM, Dusad A, Klassen LW, Duryee MJ, Mikuls TR, West WW, Wang D, Bailey KL.Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure. J Toxicol Environ Health A.2015;78(19):1201-16. doi: 10.1080/15287394.2015.1075165. Epub 2015 Oct 5. PubMed PMID: 26436836; PubMed Central PMCID: PMC4706168.
Knudsen M, Bury M, Holwegner C, Reinhardt AL, Yuan F, Zhang Y, Giannini P, Marx DB, Wang D, Reinhardt RA. Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats. Arthritis Res Ther. 2015 Sep 24;17:267. doi: 10.1186/s13075-015-0772-5. PubMed PMID: 26400235; PubMed Central PMCID: PMC4581092.
Ren K, Yuan H, Zhang Y, Wei X, Wang D. Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis. Clin Immunol. 2015 Sep;160(1):71-81. doi: 10.1016/j.clim.2015.03.027. Epub 2015 Apr 11. PubMed PMID: 25869296.
Mogen AB, Chen F, Ahn SJ, Burne RA, Wang D, Rice KC. Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms. PLoS One. 2015;10(7):e0133886. doi: 10.1371/journal.pone.0133886. eCollection 2015. PubMed PMID: 26222384; PubMed Central PMCID: PMC4519314.
Dusad A, Thiele GM, Klassen LW, Wang D, Duryee MJ, Mikuls TR, Staab EB, Wyatt TA, West WW, Reynolds SJ, Romberger DJ, Poole JA. Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice. Immunol Res. 2015 May;62(1):46-59. doi: 10.1007/s12026-015-8634-4. PubMed PMID: 25759026; PubMed Central PMCID: PMC4426061.
Jia Z, Zhang Y, Chen YH, Dusad A, Yuan H, Ren K, Li F, Fehringer EV, Purdue PE, Goldring SR, Daluiski A, Wang D. Simvastatin prodrug micelles target fracture and improve healing. J Control Release. 2015 Feb 28;200:23-34. doi: 10.1016/j.jconrel.2014.12.028. Epub 2014 Dec 24. PubMed PMID: 25542644; PubMed Central PMCID: PMC4315241.
2014
Chen F, Jia Z, Rice KC, Reinhardt RA, Bayles KW, Wang D. The development of drug-free therapy for prevention of dental caries. Pharm Res. 2014 Nov;31(11):3031-7. doi: 10.1007/s11095-014-1396-1. Epub 2014 May 15. PubMed PMID: 24831311; PubMed Central PMCID: PMC4425309.
Zhang Y, Bradley AD, Wang D, Reinhardt RA. Statins, bone metabolism and treatment of bone catabolic diseases. Pharmacol Res. 2014 Oct;88:53-61. doi: 10.1016/j.phrs.2013.12.009. Epub 2014 Jan 7. Review. PubMed PMID: 24407282.
Ren K, Dusad A, Zhang Y, Purdue PE, Fehringer EV, Garvin KL, Goldring SR, Wang D. Early diagnosis of orthopedic implant failure using macromolecular imaging agents. Pharm Res. 2014 Aug;31(8):2086-94. doi: 10.1007/s11095-014-1310-x. Epub 2014 Mar 4. PubMed PMID: 24590878; PubMed Central PMCID: PMC4155031.
Ren K, Dusad A, Yuan F, Yuan H, Purdue PE, Fehringer EV, Garvin KL, Goldring SR, Wang D. Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects. J Control Release. 2014 Feb 10;175:1-9. doi: 10.1016/j.jconrel.2013.11.024. Epub 2013 Dec 8. PubMed PMID: 24326124; PubMed Central PMCID: PMC3946775.
Dusad A, Duryee MJ, Shaw AT, Klassen LW, Anderson DR, Wang D, Ren K, Gravallese EM, O'Dell JR, Mikuls TR, Thiele GM. Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant. Immunol Res. 2014 Jan;58(1):51-60. doi: 10.1007/s12026-013-8479-7. PubMed PMID: 24371010.
Quan L, Zhang Y, Crielaard BJ, Dusad A, Lele SM, Rijcken CJF, Metselaar JM, Kostková H, Etrych T, Ulbrich K, Kiessling F, Mikuls TR, Hennink WE, Storm G, Lammers T, Wang D. Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes. ACS Nano. 2014 Jan 28;8(1):458-466. doi: 10.1021/nn4048205. Epub 2013 Dec 27. PubMed PMID: 24341611; PubMed Central PMCID: PMC3947749.
2013
Yuan F, Tabor DE, Nelson RK, Yuan H, Zhang Y, Nuxoll J, Bynoté KK, Lele SM, Wang D, Gould KA. A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis. PLoS One. 2013;8(11):e81483. doi: 10.1371/journal.pone.0081483. eCollection 2013. PubMed PMID: 24312306; PubMed Central PMCID: PMC3842961.
Chen F, Jia Z, Rice KC, Reinhardt RA, Bayles KW, Wang D. The development of dentotropic micelles with biodegradable tooth-binding moieties. Pharm Res. 2013 Nov;30(11):2808-17. doi: 10.1007/s11095-013-1105-5. Epub 2013 Jun 14. PubMed PMID: 23765401.
Ren K, Dusad A, Zhang Y, Wang D. Therapeutic intervention for wear debris-induced aseptic implant loosening. Acta Pharmaceutica Sinica B. 2013 April; 3(2):76-85. doi: 10.1016/j.apsb.2013.02.005.
Jia Z, Singh RK, Wang D. Click Cyclodextrins for Biomedical Applications . In: Click Chemistry in Glycoscience. Witczak ZJ, Bielski R, editors.Hoboken, New Jersey: John Wiley & Sons; 2013. 271-292p.
Price U, Le HO, Powell SE, Schmid MJ, Marx DB, Zhang Y, Wang D, Narayana N, Reinhardt RA. Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss. J Periodontal Res. 2013 Oct;48(5):541-8. doi: 10.1111/jre.12036. Epub 2012 Dec 30. PubMed PMID: 23278592.
Purdue PE, Levin AS, Ren K, Sculco TP, Wang D, Goldring SR. Development of polymeric nanocarrier system for early detection and targeted therapeutic treatment of peri-implant osteolysis. HSS J. 2013 Feb;9(1):79-85. doi: 10.1007/s11420-012-9307-7. Epub 2012 Dec 27. PubMed PMID: 24426848; PubMed Central PMCID: PMC3640727.
2012
Killeen AC, Rakes PA, Schmid MJ, Zhang Y, Narayana N, Marx DB, Payne JB, Wang D, Reinhardt RA. Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. J Periodontol. 2012 Dec;83(12):1463-71. doi: 10.1902/jop.2012.110683. Epub 2012 Mar 16. PubMed PMID: 22420870.
Yuan F, Nelson RK, Tabor DE, Zhang Y, Akhter MP, Gould KA, Wang D. Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects. Arthritis Rheum. 2012 Dec;64(12):4029-39. doi: 10.1002/art.34667. PubMed PMID: 22886616; PubMed Central PMCID: PMC3510353.
Liu XM, Zhang Y, Chen F, Khutsishvili I, Fehringer EV, Marky LA, Bayles KW, Wang D. Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes. Pharm Res. 2012 Nov;29(11):3169-79. doi: 10.1007/s11095-012-0812-7. Epub 2012 Jun 26. PubMed PMID: 22733150; PubMed Central PMCID: PMC3601903.
Yuan F, Quan LD, Cui L, Goldring SR, Wang D. Development of macromolecular prodrug for rheumatoid arthritis. Adv Drug Deliv Rev. 2012 Sep;64(12):1205-19. doi: 10.1016/j.addr.2012.03.006. Epub 2012 Mar 10. Review. PubMed PMID: 22433784; PubMed Central PMCID: PMC3572768.
Thiele GM, Duryee MJ, Dusad A, Hunter CD, Lacy JP, Anderson DR, Wang D, O'Dell JR, Mikuls TR, Klassen LW. Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis. Int Immunopharmacol. 2012 Aug;13(4):424-31. doi: 10.1016/j.intimp.2012.05.007. Epub 2012 May 21. PubMed PMID: 22626832.
Crielaard BJ, Rijcken CJ, Quan L, van der Wal S, Altintas I, van der Pot M, Kruijtzer JA, Liskamp RM, Schiffelers RM, van Nostrum CF, Hennink WE, Wang D, Lammers T, Storm G. Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7254-8. doi: 10.1002/anie.201202713. Epub 2012 Jun 12. PubMed PMID: 22692876; PubMed Central PMCID: PMC3499037.
2011
Lee Y, Liu X, Nawshad A, Marx DB, Wang D, Reinhardt RA. Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced bone. Mol Pharm. 2011 Aug 1;8(4):1035-42. doi: 10.1021/mp200045p. Epub 2011 Apr 5. PubMed PMID: 21438610; PubMed Central PMCID: PMC3148302.
Wang D, Goldring SR. The bone, the joints and the Balm of Gilead. Mol Pharm. 2011 Aug 1;8(4):991-3. doi: 10.1021/mp200328t. PubMed PMID: 21800906.
Ren K, Purdue PE, Burton L, Quan LD, Fehringer EV, Thiele GM, Goldring SR, Wang D. Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates. Mol Pharm. 2011 Aug 1;8(4):1043-51. doi: 10.1021/mp2000555. Epub 2011 Apr 12. PubMed PMID: 21438611; PubMed Central PMCID: PMC3148351.
Yuan F, Thiele GM, Wang D. Nanomedicine Development for Autoimmune Diseases. Drug development research. 2011; 72:703.
2010
Hein CD, Liu XM, Chen F, Cullen DM, Wang D. The synthesis of a multiblock osteotropic polyrotaxane by copper(I)-catalyzed huisgen 1,3-dipolar cycloaddition. Macromol Biosci. 2010 Dec 8;10(12):1544-56. doi: 10.1002/mabi.201000205. Epub 2010 Oct 15. PubMed PMID: 20954201.
Chen F, Rice KC, Liu XM, Reinhardt RA, Bayles KW, Wang D. Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm. Pharm Res. 2010 Nov;27(11):2356-64. doi: 10.1007/s11095-010-0119-5. Epub 2010 Apr 13. PubMed PMID: 20387099; PubMed Central PMCID: PMC2957528.
Liu XM, Quan LD, Tian J, Laquer FC, Ciborowski P, Wang D. Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis. 2010 Oct 11;11(10):2621-8. doi: 10.1021/bm100578c. PubMed PMID: 20831200; PubMed Central PMCID: PMC2966310.
Quan LD, Purdue PE, Liu XM, Boska MD, Lele SM, Thiele GM, Mikuls TR, Dou H, Goldring SR, Wang D. Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. Arthritis Res Ther.2010;12(5):R170. doi: 10.1186/ar3130. Epub 2010 Sep 13. PubMed PMID: 20836843; PubMed Central PMCID: PMC2990997.
Quan LD, Yuan F, Liu XM, Huang JG, Alnouti Y, Wang D. Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model. Mol Pharm. 2010 Aug 2;7(4):1041-9. doi: 10.1021/mp100132h. PubMed PMID: 20557133; PubMed Central PMCID: PMC2914173.
Chen F, Wang D. Novel technologies for the prevention and treatment of dental caries: a patent survey. Expert Opin Ther Pat. 2010 May;20(5):681-94. doi: 10.1517/13543771003720491. Review. PubMed PMID: 20230309; PubMed Central PMCID: PMC2857592.
2009
2008
Liu XM, Quan LD, Tian J, Alnouti Y, Fu K, Thiele GM, Wang D. Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharm Res. 2008 Dec;25(12):2910-9. doi: 10.1007/s11095-008-9683-3. Epub 2008 Jul 23. PubMed PMID: 18649124; PubMed Central PMCID: PMC2593120.
Miller SC, Pan H, Wang D, Bowman BM, Kopecková P, Kopecek J. Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharm Res. 2008 Dec;25(12):2889-95. doi: 10.1007/s11095-008-9706-0. Epub 2008 Aug 29. PubMed PMID: 18758923; PubMed Central PMCID: PMC2727931.
Wang D. Targeted delivery for musculoskeletal diseases. Pharm Res. 2008 Dec;25(12):2878-80. doi: 10.1007/s11095-008-9716-y. Epub 2008 Sep 5. PubMed PMID: 18773145; PubMed Central PMCID: PMC2701446.
Hein CD, Liu XM, Wang D. Click chemistry, a powerful tool for pharmaceutical sciences. Pharm Res. 2008 Oct;25(10):2216-30. doi: 10.1007/s11095-008-9616-1. Epub 2008 May 29. Review. PubMed PMID: 18509602; PubMed Central PMCID: PMC2562613.
Quan LD, Thiele GM, Tian J, Wang D. The Development of Novel Therapies for Rheumatoid Arthritis. Expert Opin Ther Pat. 2008 Jul;18(7):723-738. doi: 10.1517/13543776.18.7.723. PubMed PMID: 19578469; PubMed Central PMCID: PMC2491719.
Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J. Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Mol Pharm. 2008 Jul-Aug;5(4):548-58. doi: 10.1021/mp800003u. Epub 2008 May 28. PubMed PMID: 18505266; PubMed Central PMCID: PMC4595038.
Liu XM, Wiswall AT, Rutledge JE, Akhter MP, Cullen DM, Reinhardt RA, Wang D. Osteotropic beta-cyclodextrin for local bone regeneration. 2008 Apr;29(11):1686-92. doi: 10.1016/j.biomaterials.2007.12.023. Epub 2008 Jan 15. PubMed PMID: 18199479; PubMed Central PMCID: PMC2323455.
Hein CD, Liu X, Wang D. The design and synthesis of an osteotropic polyrotaxane for the treatment of skeletal diseases. Polymer preprints. 2008; 49:248.
2007
Pan H, Kopecková P, Liu J, Wang D, Miller SC, Kopecek J. Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Pharm Res.2007 Dec;24(12):2270-80. doi: 10.1007/s11095-007-9449-3. Epub 2007 Sep 25. PubMed PMID: 17899324.
Liu XM, Lee HT, Reinhardt RA, Marky LA, Wang D. Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity. J Control Release. 2007 Sep 11;122(1):54-62. doi: 10.1016/j.jconrel.2007.06.021. Epub 2007 Jun 28. PubMed PMID: 17673326.
Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopecková P, Lyubchenko Y, Higuchi WI, Kopecek J. Osteotropic Peptide that differentiates functional domains of the skeleton. Bioconjug Chem. 2007 Sep-Oct;18(5):1375-8. doi: 10.1021/bc7002132. Epub 2007 Aug 17. PubMed PMID: 17705416.
Liu XM, Thakur A, Wang D. Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. 2007 Sep;8(9):2653-8. doi: 10.1021/bm070430i. Epub 2007 Aug 10. PubMed PMID: 17688321.
Wang D, Miller SC, Liu XM, Anderson B, Wang XS, Goldring SR. Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Arthritis Res Ther. 2007;9(1):R2. doi: 10.1186/ar2106. PubMed PMID: 17233911; PubMed Central PMCID: PMC1860059.
2006
Wang D, Sima M, Mosley RL, Davda JP, Tietze N, Miller SC, Gwilt PR, Kopecková P, Kopecek J. Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers. Mol Pharm. 2006 Nov-Dec;3(6):717-25. doi: 10.1021/mp0600539. PubMed PMID: 17140259; PubMed Central PMCID: PMC2504859.
Liu XM, Reinhardt RA, Wang D. Drug delivery strategies for common orofacial diseases. J Drug Target. 2006 Sep;14(8):583-97. doi: 10.1080/10611860600834433. Review. PubMed PMID: 17050124.
Pan H, Kopecková P, Wang D, Yang J, Miller S, Kopecek J. Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target. 2006 Jul;14(6):425-35. doi: 10.1080/10611860600834219. PubMed PMID: 17092842.
Chivukula P, Dusek K, Wang D, Dusková-Smrcková M, Kopecková P, Kopecek J. Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels. 2006 Mar;27(7):1140-51. doi: 10.1016/j.biomaterials.2005.07.020. Epub 2005 Aug 11. PubMed PMID: 16098577.
2005
2004
Wang D, Miller SC, Sima M, Parker D, Buswell H, Goodrich KC, Kopecková P, Kopecek J. The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res. 2004 Oct;21(10):1741-9. doi: 10.1023/b:pham.0000045232.18134.e9. PubMed PMID: 15553217.
Wang D, Li W, Pechar M, Kopecková P, Brömme D, Kopecek J. Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Int J Pharm. 2004 Jun 11;277(1-2):73-9. doi: 10.1016/j.ijpharm.2003.03.003. Review. PubMed PMID: 15158970.
2003
2002
Wang D, Pechar M, Li W, Kopecková P, Brömme D, Kopecek J. Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors. 2002 Jul 16;41(28):8849-59. doi: 10.1021/bi0257080. PubMed PMID: 12102627.
Wang D, Dušek K, Kopečková P, Dušková-Smrčková M, Kopeček J. Novel Aromatic Azo Containing pH Sensitive Hydrogels: Synthesis and Characterization. Macromolecules. 2002; 35:7791.
2001
Wang D, Zhang G, Feng X, Gu Z, Yang J, Ye W. Copolymerization of L-Lactide with (3S)-3-[(Benzyloxycarbonyl)methyl]morpholine-2,5-dione and Degradation Behavior of the Deprotected Copolymers. Macromolecular Chemistry Symposia. 2001; 14(2):247.
2000
1998
王 东, 冯 新德. 生物降解型聚酯的功能化及其亲水性的改善. 高分子通报. 1998; (2):32. doi: 10.14028/j.cnki.1003-3726.1998.02.005.
邢 玉清, 王 东. 微胶囊化光降解剂的合成. 材料科学与工艺. 1998; (2):106.
Wang D, Feng X. Copolymerization of ε-Caprolactone with (3S)-3-[(Benzyloxycarbonyl)methyl]morpholine-2,5-dione and the 13C NMR Sequence Analysis of the Copolymer. Macromolecules. 1998; 31:3824.
Zhang G, Wang D, Feng X. Preliminary Study of Hydrogen Bonding in (3S)-3-[(Benzyloxycarbonyl)methyl]morpholine-2,5-dione and Its effect on Polymerization. Macromolecules. 1998; 31:6390.
1997
Wang D, Feng X. Synthesis of Poly(glycolic acid-alt-L-aspartic acid) from a Morpholine-2,5-dione Derivative. Macromolecules. 1997; 30:5688.
1994
邢 玉清, 王 东, 侯 彩虹. 杀螟硫磷微胶囊化的研究. 哈尔滨工业大学学报. 1994; (3):88.
1992
邢 玉清, 王 东. 城市废弃物中废旧塑料的回收. 环境卫生工程. 1992; (4):9.
邢 玉清, 王 东, 金 庆镐. 核-壳结构丙烯酸酯类乳液型可剥涂料的研制. 化学与粘合. 1992; (4):212.