UNMC_Acronym_Vert_sm_4c
University of Nebraska Medical Center

Gurudutt Pendyala, PhD

Robert Lieberman Endowed Professor of Anesthesiology
Professor, UNMC Department of Anesthesiology
Adjunct Professor, UNMC Department of Genetics, Cell Biology and Anatomy

Gurudutt Pendyala, PhD
  • Neuroinflammation associated with long-term use of psychostimulant drugs (methamphetamine, nicotine) at the synapse
  • Prenatal drug exposure and synaptic development
  • Application of novel anti-inflammatory drugs to attenuate inflammation at the synapse
  • Sex differences and drug abuse
  • Molecular mechanisms of microRNAs at the synapse
  • Role of extracellular vesicles in drug addiction and HIV infection

Guda R, Tan C, Schaal VL, Yelamanchili SV and Pendyala, G (2021) “Integrated systems analysis of mixed neuroglial cultures post oxycodone exposure International Journal of Molecular Sciences 22, 6421. https://doi.org/10.3390/ ijms22126421. PMID: 34203972 

Doke, M, Pendyala G and Thangavel S (2021) “Psychostimulants and Opioids Differentially Influence the Epigenetic Modification of Histone Acetyltransferase and Histone Deacetylase” PLoS One Jun 11;16(6):e0252895. doi: 10.1371/journal.pone.0252895. eCollection 2021. PMID: 34115777 

Odegaard K, Pendyala G and Yelamanchili SV (2021). “Generational effects of opioid exposure”. Encyclopedia 1(1), 99-114  https://doi.org/10.3390/encyclopedia1010012 

NIH/R01DA059177 
Award Period: 08/01/2023-07/31/2026 
Title: “Strategies to define and mitigate the placental and fetal alterations caused by maternal oxycodone exposure” 
Role: Principal Investigator 

NIH/R21ES034956 
Award Period: 08/01/2023-07/31/2025 
Title: “Brain derived extracellular vesicles-mediated neurotoxicity of deltamethrin” 
Role: Principal Investigator 

NIH/NIDA R01DA046852 
Award Period: 09/30/2018-08/31/2023 
Title: “Extracellular vesicles, meth relapse and sex differences” 
Role: Principal Investigator