University of Nebraska Medical Center

Gurudutt Pendyala, PhD

Robert Lieberman Endowed Professor of Anesthesiology
Associate Professor, UNMC Department of Anesthesiology
Research Faculty

Gurudutt Pendyala, PhD
Research Interests
  • Neuroinflammation associated with long-term use of psychostimulant drugs (methamphetamine, nicotine) at the synapse
  • Prenatal drug exposure and synaptic development
  • Application of novel anti-inflammatory drugs to attenuate inflammation at the synapse
  • Sex differences and drug abuse
  • Molecular mechanisms of microRNAs at the synapse
  • Role of extracellular vesicles in drug addiction and HIV infection

Guda R, Tan C, Schaal VL, Yelamanchili SV and Pendyala, G (2021) “Integrated systems analysis of mixed neuroglial cultures post oxycodone exposure International Journal of Molecular Sciences 22, 6421. https://doi.org/10.3390/ ijms22126421. PMID: 34203972 

Doke, M, Pendyala G and Thangavel S (2021) “Psychostimulants and Opioids Differentially Influence the Epigenetic Modification of Histone Acetyltransferase and Histone Deacetylase” PLoS One Jun 11;16(6):e0252895. doi: 10.1371/journal.pone.0252895. eCollection 2021. PMID: 34115777 

Odegaard K, Pendyala G and Yelamanchili SV (2021). “Generational effects of opioid exposure”. Encyclopedia 1(1), 99-114  https://doi.org/10.3390/encyclopedia1010012 


Award Period: 08/01/2023-07/31/2026 
Title: “Strategies to define and mitigate the placental and fetal alterations caused by maternal oxycodone exposure” 
Role: Principal Investigator 

Award Period: 08/01/2023-07/31/2025 
Title: “Brain derived extracellular vesicles-mediated neurotoxicity of deltamethrin” 
Role: Principal Investigator 

NIH/NIDA R01DA046852 
Award Period: 09/30/2018-08/31/2023 
Title: “Extracellular vesicles, meth relapse and sex differences” 
Role: Principal Investigator