University of Nebraska Medical Center
University of Nebraska Medical Center

Wallace B. Thoreson, PhD

Professor Emeritus, UNMC Department of Ophthalmology and Visual Sciences

Wallace Thoreson, PhD

Wallace B. Thoreson, PhD, is a professor emeritus in the Department of Ophthalmology and Visual Sciences at UNMC.

Although now retired from UNMC, he plans to continue his work if the field of retinal physiology to see the projects to completion.

  • Bachelor's: Carleton College, Northfield, Minnesota
  • Master's: Cold Spring Harbor Laboratory, New York
  • PhD: University of Minnesota, Minneapolis
  • Post-doctoral training: Neuroscience, University of Minnesota, Minneapolis

Dr. Thoreson’s lab uses a variety of state-of-the-art electrophysiological and imaging techniques to study the physiology of retinal neurons in vision.  His particular focus is on the mechanisms by which rod and cone photoreceptor cells transmit their light responses to downstream neurons in the retina.  Neurotransmission at this first synapse in the retina shapes our perception by governing the information available to the visual system. In addition to understanding how these mechanisms shape our perception, these experiments also provide important foundation for the treatment of retinal diseases.  Restoring vision by therapeutic means requires an understanding of the steps that take place during normal vision. Furthermore, damage to many of the proteins involved in neurotransmission from photoreceptors can cause rods and cones to degenerate. Over-stimulation of calcium channels and glutamate receptors at the photoreceptor synapse can also promote neurodegeneration in eye diseases such as glaucoma, stroke, and ischemia.