University of Nebraska Medical Center

Kishor Bhakat, PhD

Professor, Department of Genetics, Cell Biology, and Anatomy


Headshot of Kishor Bhakat, PhD
The major goals of Dr. Bhakat's lab are to understand the molecular mechanisms that alter the damage repair pathways and gene expression in tumor cells to promote therapy resistance and tumor recurrence and develop second line of interventions to prevent tumor recurrence and metastasis and improve the quality of life of patients.
  • Post-doc, University of Texas Medical Branch
  • PhD, Indian Institute of Chemical Biology
  • MS, University of Calcutta, India

Tumor recurrence and metastasis remain the major clinical challenges for cancer treatment. Ionizing radiation (IR) and chemotherapies have been the first line of care for treatment of many types of cancers including brain and pancreatic cancer. These conventional cytotoxic therapies cause DNA damage and induce cell death. Although this standard of care has significantly improved the overall survival rates, high doses of chemo and IR are associated with long-term toxicities in surviving patients. Moreover, postsurgical residual tumor in some groups of patients rapidly develop therapy-resistant which often leads to tumor recurrence and distal metastasis.

Selected Publications
  1. Pramanik S, Chen Y, Song H, Khutsishvili I, Marky LA, Ray S, Natarajan A, Singh PK, Bhakat KK. The Human AP-endonuclease 1 (APE1) is a DNA G-quadruplex Structure Binding Protein and Regulates KRAS Expression in Pancreatic Ductal Adenocarcinoma Cells. Nucleic Acids Res. (2022),50:3394-3412. PMCID: PMC8990529   DOI: 1093/nar/gkac172
  2. Song, H., Xi, , Chen, Y.,  Pramanik,  S.,  Zeng, J , Roychoudhury , S., Harris , H., Akbar , A.,  Elhag , S.,  Coulter , D.,  Ray , S.,  Bhakat, KK.. Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation. Cancer Lett. (2021), 520:201-212. PMCID: PMC8440470  DOI: 10.1016/j.canlet.2021.07.020
  3. Pramanik S, Roychoudhury S and Bhakat KK. Oxidized DNA base damage repair and transcription: a new mechanism for regulation of gene expression in cancer. Handbook of Oxidative stress and Cancer, Springer Nature (2022).