University of Nebraska Medical Center

Rana Al-Sadi, PhD

Assistant Professor, Division of Gastroenterology and Hepatology


Rana Al-Sadi, PhD

Dr. Al-Sadi's research focus for more than 15 years has been to delineate the role of defective intestinal epithelial tight junction (TJ) barrier in the pathogenesis of inflammatory bowel disease (IBD), to elucidate the pathogenic mechanism involved in dysregulation of intestinal TJ barrier in IBD; and to discover novel therapeutic agents to enhance the intestinal TJ barrier during disease states.

Recent work has focused on: the role of matrix metalloproteinase-9 (MMP-9) in TJ barrier dysregulation, and the TJ enhancement effect of probiotic bacterial stains that prevent intestinal inflammation. Dr. Al-Sadi has extensive expertise delineating the intracellular and molecular mechanisms of intestinal TJ barrier regulation in in-vitro (cell-culture) and in-vivo (live mouse intestinal permeability studies) models, using cutting-edge cell biology and molecular approaches.


  • Intestinal epithelial Tight junction barrier
  • Inflammatory bowel disease (IBD), Crohn's and Ulcerative Colitis
  • Epithelial biology and physiology
  • Probiotic enhancement of the intestinal barrier
  • BS: Biology, University of Jordan, Amman, Jordan (1997)
  • MS: Biology, American University of Beirut, Beirut, Lebanon (2002)
  • PhD: Biomedical Sciences, Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico (2007)