Kendra Clark, PhD
Assistant Professor
Department of Obstetrics and Gynecology
Department of Environmental, Agricultural, and Occupational Health
Research Overview
The ovary produces the female egg, the oocyte, and hormones which are critical for reproduction and quality-of-life. The effect of a chemical exposure on female reproductive function depends on the developmental/life stage of the exposure as well as the level and duration of exposure. Ovotoxicants can selectively target a follicle population in the ovary, resulting in either temporary or permanent infertility, alter ovarian function maternally, and can also impact offspring through pregestational or in utero exposures.
While many factors contribute to the global trend in the decline of reproduction rates, the role of environmental exposures in the development of reproductive disorders warrants further investigation. My research program aims to identify the molecular mechanisms responsible for chemical-induced ovarian toxicity, specifically per- and polyfluoroalkyl substances (PFAS). From this, we can provide the means to prevent environmentally induced reproductive failure and preserve fertility. Furthermore, the findings from our research will contribute to the broader understanding of PFAS toxicity, with the overarching goal of informing risk assessment and regulatory strategies to protect public health.
Information
Undergraduate Degree
BS in Biology (major) and Genetics (minor)
Iowa State University, Ames, Iowa
Graduate Training
PhD in Genetics and Genomics
Iowa State University, Ames, Iowa
Post-Doctoral Fellowship
Area of Study: Reproductive Endocrinology
University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska
Publications for Kendra L. Clark, PhD
Recent publications:
- "Perfluorodecanoic acid (PFDA) induces oxidative stress and autophagy dysregulation in HGrC1 cells" This study shows that PFDA exposure triggers oxidative stress and disrupts autophagy in human granulosa cells, potentially impacting ovarian function and fertility. Read the full article.
- "Environmental and occupational risks to reproductive health in women service members and veterans" This mini-review examines environmental and occupational exposures in military women, such as burn pits and heavy metals, and their potential effects on fertility and pregnancy outcomes. Read the full article.
- "Environmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation, migration, and gene transcription in a human myometrial cell line" This research explores how PFAS exposure affects uterine cell behavior, including proliferation, migration, and gene expression, with implications for reproductive health. Read the full article.
Determining mechanisms of ovotoxicity of per- and polyfluoroalkyl substances
Department of Veterans Affairs, Career Development Award (CDA-2)
04/2024 – 03/2029
PI: Clark, KL
