University of Nebraska Medical Center

William Rizzo Lab

Dr. William Rizzo in doctor's office

We investigate a rare neurocutaneous disease, Sjogren-Larsson syndrome, caused by genetic deficiency of fatty aldehyde dehydrogense. Research projects range from clinical trials to biochemical and molecular studies to understand the pathogenic mechanisms of symptoms, develop new therapeutic approaches, and characterize the clinical features.

Areas of Interest
  • Lipid metabolism and particularly fatty alchols and aldehydes
  • Mutation analysis
  • Fatty acid metabolism
  • Clinical trials
Current Funding
  • NIH
  • Pharmaceutical companies
  • Other
Lab Contact Information
William B. Rizzo, MD
Scientific Director, Child Health Research Institute
Helen Freytag Chair in Pediatrics
Department of Pediatrics
985940 Nebraska Medical Center – DRC II 4064
Omaha, NE 68198-5940
Telephone: 402-559-2560
Lab Personnel
Dana S'aulis, Research Technologist II
Ed Siefker, Research Technologist I
Lab Techniques
  • Enzyme assays
  • Lipid analysis by GC-MS, TLC, etc;
  • Cell culture
  • In situ mutagenesis
  • Gene expression measurements using RT-PCR
  • Organelle