University of Nebraska Medical Center

Zeljka Korade Lab

Lab equipment

We investigate diseases due to mutations in enzymes of cholesterol biosynthesis pathway. Our research projects include studies of mouse models of neurodevelopmental disorders. We analyze the biochemical and molecular changes to understand the pathogenic mechanisms of disease and develop therapeutic approaches. Additional experiments include high-throughput screening and analysis of the effects of small molecules on cholesterol synthesis and metabolism.

Lab Contact Information
Zeljka Korade, DVM, PhD
Professor of Pediatrics and Biochemistry and Molecular Biology
University of Nebraska Medical Center
982165 Nebraska Medical Center | Omaha, NE 68198
Phone: 402.559.1312
Areas of Interest
  • Smith-Lemli-Opitz Syndrome
  • Desmosterolosis
  • Lathosterolosis
  • Brain development
  • Small molecules and cholesterol metabolism
Current Funding
Lab Techniques
  • Immunohistochemistry
  • Gene expression measurements using qPCR and Nanostring
  • Cell cultures
  • Microscopy
  • Western blotting
  • High-throughput screening
  • Sterol measurements by LC-MS/MS