University of Nebraska Medical Center

Targets, Modulators, and Delivery Program

This program is developing and delivering small molecules to modulate validated cancer targets as eventual cancer therapeutics.

The program brings together investigators with complementary expertise to facilitate translation of basic science discoveries across the bench-to-bedside continuum within the research programs of the Eppley Institute and its partner, the Fred & Pamela Buffett Cancer Center. 

Areas of expertise include:

  • Cancer target validation and characterization
  • Medicinal chemistry
  • Pharmacology
  • Nanodelivery

The program has led efforts to establish several shared resources, including the Synthetic and Medicinal Chemistry Resource, the Computational Chemistry Resource, and the Translational Drug Development Resource.


Edward and Lida Robinson Professor of Cancer Research, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Director, Nebraska Center for Molecular Target Discovery and Development
Research Focus: Cell growth and metabolism


Laboratory of Robert Lewis, PhD

Robert Lewis

Professor, Division of Oncology & Hematology
Director, Pilot Projects Program, Great Plains IDeA-CTR

Sarah Holstein, MD

Ruth Branham Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Co-Director, Eppley Structural Biology Facility
Research focus: Developing novel target and mechanism specific therapeutics


Laboratory Website

Amar Natarajan