Sidharth Mahapatra, MD, PhD

mahapatra,_sidharth_horizontal_unmc_medium.jpgAcademic Appointments
Associate Professor, Department of Pediatrics, University of Nebraska College of Medicine
Associate Professor, Department of Biochemistry, University of Nebraska College of Medicine
Assistant Professor, Department of Pediatrics, Creighton University School of Medicine
Assistant Professor, Department of Biomedical Sciences, Creighton University School of Medicine

Director for Research, Pediatric Critical Care Medicine

Clinical Practice Location
Children’s Hospital & Medical Center
8200 Dodge Street, Omaha, NE 68114

Lab/Academic Office
University of Nebraska Medical Center
DRC 1, 601 South Saddle Creek Road, Omaha, NE 68106

As a pediatric intensivist with an interest in neurocritical care working in a state with a punctuated incidence of pediatric brain tumors, I aspire to carve my academic niche studying pediatric medulloblastomas (MB), the most common malignant brain tumor of childhood. Serving as an intersection for my training in molecular neurobiology, my strong interest in translational science, and my burgeoning expertise in pediatric critical care medicine, I hope to significantly impact the long term survivorship of patients with high-risk medulloblastomas, who suffer high relapse rates and mortality.

My secondary clinical interest lies in the study of acute lung injury and pediatric acute respiratory distress syndrome (PARDS). I am an active member of the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI). We have participated in several landmark study including the Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE) and are now engaged in the Prone and Oscillator in Pediatrics Clinical Trial (PROSpect) aimed at studying treatment strategies in severe PARDS. Over my career, I aspire to actively engage with collaborators in an effort to mitigate PARDS in the field of critical care.

Board Certification
Pediatric Critical Care Medicine

2009    M.D., Ph.D., Rosalind Franklin University of Medicine and Sciences, North Chicago, IL
2012    Residency in Pediatrics, Lucile Packard Children's Hospital, Stanford, CA
2015    Fellowship in Pediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford, CA

Primary Interests

  1. To define pathophysiologicevents triggering neoplastic transformation in pediatric brain tumors
  2. To generate preclinical mouse models of pediatric brain tumors, using our understanding of pathophysiology
  3. To generate novel anti-neoplastic agents using cutting-edge bioinformatics tools that may be tested in our genetically-engineered mouse models

Active Grants

   1. PCCTSDP K12 Scholar Award (K12HD047349)  01/01/2021 – 12/31/2022

Project Title: MiR-1253 potentiates cisplatin response in group 3 medulloblastoma through ferroptosis

   2. Team Jack Brain Tumor Foundation Award        01/01/2020 – 12/30/2022

Project Title: Chemosensitization of non-SHH/WNT medulloblastoma is regulated by miR-125

 Professional Organizations

Honors & Awards

Links and Multimedia