University of Nebraska Medical Center

Sidharth Mahapatra, MD, PhD

Associate Professor, Division of Critical Care

Sidharth Mahapatra, MD, PhD

As a pediatric intensivist with an interest in neurocritical care working in a state with a punctuated incidence of pediatric brain tumors, I aspire to carve my academic niche studying pediatric medulloblastomas (MB), the most common malignant brain tumor of childhood. Serving as an intersection for my training in molecular neurobiology, my strong interest in translational science, and my burgeoning expertise in pediatric critical care medicine, I hope to significantly impact the long term survivorship of patients with high-risk medulloblastomas, who suffer high relapse rates and mortality.

My secondary clinical interest lies in the study of acute lung injury and pediatric acute respiratory distress syndrome (PARDS). I am an active member of the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI). We have participated in several landmark study including the Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE) and are now engaged in the Prone and Oscillator in Pediatrics Clinical Trial (PROSpect) aimed at studying treatment strategies in severe PARDS. Over my career, I aspire to actively engage with collaborators in an effort to mitigate PARDS in the field of critical care.

About Dr. Mahapatra


Medical School
Rosalind Franklin University of Medicine and Sciences, North Chicago, IL

Pediatrics, Lucile Packard Children's Hospital, Stanford, CA

Pediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford, CA

Research Interests
  • To define pathophysiologicevents triggering neoplastic transformation in pediatric brain tumors
  • To generate preclinical mouse models of pediatric brain tumors, using our understanding of pathophysiology
  • To generate novel anti-neoplastic agents using cutting-edge bioinformatics tools that may be tested in our genetically-engineered mouse models
Board Certification

Pediatric Critical Care Medicine

Additional Academic Roles
  • Associate Professor, Department of Biochemistry, University of Nebraska College of Medicine
  • Assistant Professor, Department of Pediatrics, Creighton University School of Medicine
  • Assistant Professor, Department of Biomedical Sciences, Creighton University School of Medicine
Active Grants

1. PCCTSDP K12 Scholar Award (K12HD047349) 01/01/2021 – 12/31/2022

Project Title: MiR-1253 potentiates cisplatin response in group 3 medulloblastoma through ferroptosis

2. Team Jack Brain Tumor Foundation Award 01/01/2020 – 12/30/2022

Project Title: Chemosensitization of non-SHH/WNT medulloblastoma is regulated by miR-125

Professional Organizations
  • Sigma Xi (1999-present)
  • American Academy of Pediatrics (2009-present)
    • Fellow (2015-present)
    • Section on Critical Care (2016-present)
    • NE Chapter Executive Board (2019-present)
  • Society for Critical Care Medicine (2012-present)
  • American Federation for Medical Research (2015-present)
    • Western Section Councilor (2015-2017)
    • National Council Executive Board (2017-2021, 2022-present)
    • Midwest Section Chair (2021-2022)
  • Society for Pediatric Research, Junior Section (2016-present)
  • Pediatric Acute Lung Injury and Sepsis Investigators Site Director (2016-present)
  • American Academy of Cancer Research (2017-present)
  • Society for Neuro-Oncology (2018-present)
Honors & Awards
  • Alpha Omega Alpha (2008)
  • Gold Humanism Honors Society (2009)
  • Leonard P. Tow Humanism in Medicine (2009)
  • Dean’s Service Award, Chicago Medical School (2009)
  • Board of Trustees Scholarship Award, Chicago Medical School (2009)
  • Excellence in Teaching, Arnold P. Gold Foundation (2012)
  • Inpatient Fellow of the Year, Lucile Packard Children’s Hospital (2015)
  • Travel Award, Western Society for Clinical Investigation (2015)
  • Young Investigator Coaching Program, Society for Pediatric Research (2017)
  • Top 10 Abstract, American Academy of Pediatrics Society for Critical Care (2017)
  • UNeMED New Innovation Contributor, UNMC (2018, 2022)
  • Travel Award, Team Jack Brain Tumor Foundation (2020)
  • K Award, Midwest Clinical and Translational Science Meeting (2021)