College of Medicine
UNMC_Acronym_Vert_sm_4c
University of Nebraska Medical Center

Sidharth Mahapatra, MD, PhD

Associate Professor, UNMC Department of Pediatrics
Associate Professor, UNMC Department of Biochemistry and Molecular Biology
Chair, Nebraska Children’s Brain Tumor Collaborative
Co-Director, Pediatric Cancer Research Group

Sidharth Mahapatra, MD, PhD

As a pediatric intensivist with an interest in neurocritical care working in a state with a particularly high incidence of pediatric brain tumors (7th in the nation), I am carving my academic niche studying pediatric medulloblastomas (MB), the most common malignant brain tumor of childhood. Serving as an intersection for my training in molecular neurobiology, my strong interest in translational science, and my burgeoning expertise in pediatric critical care medicine, I hope to significantly impact the long-term survivorship of patients with high-risk medulloblastomas, who suffer high relapse rates and mortality.

My secondary clinical interest lies in the study of acute lung injury and pediatric acute respiratory distress syndrome (PARDS). I am an active member of the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI). We have participated in several landmark studies including the Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE) and are now engaged in the Prone and Oscillator in Pediatrics Clinical Trial (PROSpect) aimed at studying treatment strategies in severe PARDS. Over my career, I aspire to mitigate PARDS in the field of critical care.

About Dr. Mahapatra

Medical School/PhD Program
Rosalind Franklin University of Medicine and Sciences, North Chicago, IL


Residency
Pediatrics, Lucile Packard Children's Hospital, Stanford, CA


Fellowship
Pediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford, CA

PhD
Biochemistry/Molecular Biology
  • To uncover deregulated molecular pathways triggering aggressiveness that can be targeted therapeutically in pediatric medulloblastomas
  • To develop novel treatment strategies that target these pathways to mitigate long-term morbidity/mortality and reduce recurrence in pediatric medulloblastomas

Lab page

  • Pediatrics
  • Pediatric Critical Care Medicine
  • Assistant Professor, Department of Pediatrics, Creighton University School of Medicine 
  • Assistant Professor, Department of Biomedical Sciences, Creighton University School of Medicine
  • Co-Leader, Brain Tumor Working Group
  • Director for Research, Pediatric Critical Care Medicine
  1. Title: Silencing B7-H3 Mitigates Tumor Aggressiveness in Group 3 Medulloblastoma Funding agency: NIH/NCI (1R03CA297351-01)
    Start and end dates: 01/01/2025 – 12/31/2026
  2. Title: Deep Investigation of Gene Silencing on 17p13.3 Identifies Targetable Vulnerabilities Informing Novel Therapeutic Strategies for Pediatric Medulloblastomas
    Funding agency: Team Jack Foundation
    Start and end dates: 05/01/2023 – 04/30/2026
  3. Project Title: Developing a Regional Medulloblastoma Core Facility at the University of Nebraska Medical Center
    Funding agency: Team Jack Foundation  
    Start and end dates: 04/01/2022 – 03/31/2025
  4. Project Title: Developing a Regional Medulloblastoma Core Facility at the University of Nebraska Medical Center
    Funding agency: Pediatric Cancer Research Group  
    Start and end dates: 01/01/2022 – 12/31/2025
  5. Project Title: Using Connectivity Mapping to Identify Anti-Neoplastic Agents for High-risk Medulloblastoma
    Funding agency: Team Jack Foundation 
    Start and end dates: 07/01/2021 – 06/30/2024 (NCE)

 

Peer-Reviewed Manuscripts

  1. Mahapatra S, Mehta H, Woo SB, Neet KE. Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation. J Biol Chem. 2009;284(84):33600-13. PMID: 19762468; PMCID: PMC2785202.
  2. Mahapatra S, Belgrad J, Adeoye M. Psychotropic drug-related eosinophilia with systemic symptoms after acute caffeine ingestion. 2011;127(1):e235-8. PMID: 21135003.
  3. Mahapatra S, Chin CC, Iagaru A, Heerema-McKenney A, Twist CJ. Successful treatment of central nervous system post-transplant lymphoproliferative disorder in a pediatric patient. Pediatr Blood Cancer 2014;61(11):2107-9. PMID: 25066638.
  4. Mahapatra S, Michie SA, Sylvester K, Cornfield D. Diagnostic dilemma in the treatment of a fatal case of bloody diarrhea. J Invest Med HIC 2016;4(1): 2324709616638698. PMID: 27069937
  5. Mahapatra S, Scottoline B. Steroid-induced resolution of refractory pulmonary interstitial emphysema. J Matern Fetal Neonatal Med 2016;29(24):4092-5. PMID: 26952563.
  6. Karmakar S, Seshacharyulu P, Lakshmanan I, Chugh S, Sheinin YM, Mahapatra S, Batra SK, Ponnusamy MP. hPaf1/PD2 interacts with Oct3/4 to promote self-renewal of ovarian cancer stem cells. 2017;8(9):14806-14820. PMID: 28122356; PMCID: PMC5362445.
  7. Gautam SK, Kumar S, Cannon A, Hall B, Bhatia R, Nasser MW, Mahapatra S, Batra S, Jain M. MUC4 mucin-A therapeutic target for pancreatic ductal adenocarcinoma. Expert Opin Ther Targets. 2017;21(7):657-69. PMID: 28460571; PMCID: PMC5706649.
  8. Bhatt R*, Mahapatra S*, Axtel B, and Steinman L. Amelioration of ongoing Experimental Autoimmune Encephalomyelitis with Fluoxetine. J Neuroimmunol. 2017;313:77-81. PMID * denotes equal contribution
  9. Mahapatra S, Ananth A, Baugh N, Damian M, Enns G. Triheptanoin, a rescue for cardiogenic shock in carnitine acylcarnitine translocase deficiency. JIMD Reports 2017. PMID: 28689308.
  10. Mahapatra S, Ying L, Ho PP-K, Kurnellas M, Rothbard J, Steinman L, Cornfield D. An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis. PLoS ONE. 2018;13(7):e0199206. PMID: 29990318; PMCID: PMC6039005.
  11. Chugh S, Barkeer S, Rachagani S, Mimmakayala RK, Peruma N, Pothuraju R, Atri P, Mahapatra S, Thapa I, Talmon GA, Smith LM, Yu X, Neelamegham S, Fu J, Xia L, Ponnusamy MP, Batra SK. Disruption of C1galt1 gene promotes development and metastasis of pancreatic adenocarcinoma in mice. 2018;155(5):1608-1624. PMID: 30086262; PMCID: PMC6219903.
  12. Randolph AG, Xu R, Novak T, and Pediatric Intensive Care Influenza Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator’s Network. Vancomycin monotherapy may be insufficient to treat Methicillin-resistant Staphylococcus Aureus coinfection in children with influenza-related critical illness. Clin Infect Dis. 2019;68(3):365-372. PMID: 29893805; PMCID: PMC6336914.
  13. Khemani RG,Smith L, Lopez-Fernandez YM, Kwok J, Morzov R, Klein MJ, Yehya N, Willson D, Kneyber MCJ, Lillie J, Fernandez A, Newth CJL, Jouvet P, Thomas NJ; Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator’s Network. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir Med. 2019;7(2):115-128. PMID: 30361119; PMCID: PMC7045907.
  14. Vengoji R, Ponnusamy MP, Rachagani S, Mahapatra S, Batra SK, Shonka N, Macha MA. Novel therapies hijacking the blood brain barrier to eradicate glioblastoma cancer stem cells. 2019;40(1):2-14. PMID: 30475990; PMCID: PMC6412134.
  15. Chaturvedi N*, Mahapatra S*, Kesherwani V, Kling MJ, Shukla M, Ray S, Kanchan R, Perumal N, McGuire TR, Sharp JG, Joshi SS, Coulter DW. Role of protein methyltransferase 5 in MYC-driven medulloblastoma. BMC Cancer. 2019;19(1):1056. PMID:31694585; PMCID: * denotes equal contribution
  16. Kanchan R, Siddiqui J, Mahapatra S, Nasser MW. MicroRNAs orchestrate pathophysiology of breast cancer brain metastasis: advances in therapy. Mol Cancer. 2020;19(1):29. PMID: 32059676; PMCID: PMC7023699.
  17. Kanchan R, Perumal N, Atri P, Venkata RC, Thapa I, Klinkebiel D, Donson AM, Perry D, Punsoni M, Talmon G, Coulter D, Boue DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, and Mahapatra S. MiR-1253 exerts tumor suppressive effects in medulloblastomas via inhibition of CDK6 and CD276 (B7- H3). Brain Pathol. 2020;30(4): 732–745. PMID: 32145124; PMCID: PMC7383594.
  18. Gautam SK, Kanchan RK, Siddiqui J, Maurya SK, Rauth S, Perumal N, Atri P,Venkata RC, Mallya K, Mirza S, Ponnusamy MP, Band V, Mahapatra S, Jain M, Batra SK, Nasser MW. Blocking c-MET/ERBB1 axis prevents brain metastasis in ERBB2+ breast cancer model. Cancers (Basel). 2020;12(10):2838. PMID: 33019652; PMCID: PMC7601177.
  19. Boyd DF, Allen KE, Randolph AG, and Pediatric Intensive Care Influenza Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator’s Network. Exuberant fibroblast activity compromises lung function via ADAMTS4. 2020;587(7834):466-471. PMID: 33116313; PMCID: PMC7883627.
  20. Lenihan A, Ramos R, Nemec N, Lukowski JD, Lee J, Kendall MK, Mahapatra S. A retrospective analysis of feeding practices and complications in patients with critical bronchiolitis on non-invasive respiratory support. Children (Basel). 2021;8(5):410. PMID: 34069996; PMCID: PMC8157845.
  21. Mahapatra S and Marques Tiago. Antipsychotics – Versatility in Action. [Editorial]. Proc Natl Acad Sci USA. 2021;118(28): e2108946118. PMID: 34244436; PMCID: PMC8285980.
  22. Vengoji R, Atri P, Macha MA, Seshacharyulu P, Perumal N, Mallya K, Liu Y, Smith LM, Rachagani S, Mahapatra S, Ponnusamy MP, Jain M, Batra SK, Shonka N. Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma. J Exp Clin Cancer Res. 2021;40(1):335. PMID: 34696786; PMCID: PMC8543939.
  23. Marlow RK, Brouillette S, Williams V, Lenihan A, Nemec N, Lukowski JD, Zheng C, Cullimore ML, Mahapatra S. Risk factors associated with mechanical ventilation in critical bronchiolitis. Children(Basel). 2021;8(11):1035. PMID: 34828749; PMCID: PMC8618830.
  24. Perumal N, Kanchan RK, Doss D, Bastola N, Atria P, Venkata R, Thapa I, Klinkebiel D, Talmon G, Nasser MW, Batra SK, and Mahapatra S. MiR-212 functions as a tumor suppressor gene in group 3 medulloblastoma via targeting Nuclear Factor I/B (NFIB). Acta Neuropathologica Communications. 2021;9:195. PMID: 34922631; PMCID: PMC8684142.
  25. Ray S, Chaturvedi N, Bhakat KK, Rizzino A, Mahapatra S. Subgroup-specific diagnostic, prognostic, and predictive markers influencing pediatric medulloblastoma treatment. Diagnostics (Basel). 2021;12(1):61. PMID: 35054230; PMCID: PMC8774967.
  26. Bhalla AK, Klein MJ, Modesto I Alapont V, Emeriaud G, Kneyber MCJ, Medina A, Cruces P, Diaz F, Takeuchi M, Maddux AB, Mourani PM, Camilo C, White BR, Yehya N, Pappachan J, Di Nardo M, Shein S, Newth C, Khemani R.Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study. Crit Care. 2022;26(1):2. PMID: 34980228; PMCID: PMC8722295.
  27. Kochanek PM, Adelson PD, Rosario BL, Hutchison J, Miller Ferguson N, Ferrazzano P, O'Brien N, Beca J, Sarnaik A, LaRovere K, Bennett TD, Deep A, Gupta D, Willyerd FA, Gao S, Wisniewski SR, Bell MJ.Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury.JAMA 2022;5(3):e220891. PMID: 35267036; PMCID: PMC8914575.
  28. Bell MJ, Rosario BL, Kochanek PM, Adelson PD, Morris KP, Au AK, Schober M, Butt W, Edwards RJ, Zimmerman J, Pineda J, Le TM, Dean N, Whalen MJ, Figaji A, Luther J, Beers SR, Gupta DK, Carpenter J, Buttram S, Wisniewski SR.Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. JAMA 2022;5(7):e2220969. PMID: 35802371.
  29. Kanchan RK, Doss D, Khan P, Nasser MW, and Mahapatra S. To Kill a Cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3. BBA Reviews on Cancer 2022;1877(5):188783. PMID: 36028149.
  30. Maurya SK, Khan P, Rehman AU, Kanchan RK, Perumal N, Mahapatra S, Chand HS, Santamaria-Barria JA, Batra SK, Nasser MW.Rethinking the chemokine cascade in brain metastasis: Preventive and therapeutic implications. Semin Cancer Biol. 2022;86(3):914-930. PMID: 34968667; PMCID: PMC9234104.
  31. Khan P, Siddiqui JA, Kshirsagar PG, Venkata RC, Maurya SK, Mirzapoiazova T, Perumal N, Chaudhary S, Kanchan RK, Fatima M, Khan MA, Rehman AU, Lakshmanan I, Mahapatra S, Talmon GA, Kulkarni P, Ganti AK, Jain M, Salgia R, Batra SK, Nasser MW.MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis. Mol Cancer. 2023;22(1):1. PMID: 36597126; PMCID: PMC9811802.
  32. Novak T, Crawford JC, Hahn G, Hall MW, Thair SA, Newhams MM, Chou J, Mourani PM, Tarquinio KM, Markovitz B, Loftis LL, Weiss SL, Higgerson R, Schwarz AJ, Pinto NP, Thomas NJ, Gedeit RG, Sanders RC, Mahapatra S, Coates BM, Cvijanovich NZ, Ackerman KG, Tellez DW, McQuillen P, Kurachek SC, Shein SL, Lange C, Thomas PG, and Randolph AG. Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza. Front Immunol. 2023;14:1220028. PMID: 37533854; PMCID: PMC10390830.
  33. Emeriaud G, Pons-Òdena M, Bhalla AK, Shein SL, Killien EY, Modesto I Alapont V, Rowan C, Baudin F, Lin JC, Grégoire G, Napolitano N, Mayordomo-Colunga J, Diaz F, Cruces P, Medina A, Smith L, Khemani RG.Noninvasive ventilation for Pediatric Acute Respiratory Distress Syndrome: experience from the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study. Pediatr Crit Care Med. 2023;24(9):715-726.  PMID: 37255352; PMCID: PMC10524424.
  34. Green S, Hoover T, Doss D, Davidow K, Walter AW, Cottrell CE, and Mahapatra S. WNT-activated, MYC-amplified medulloblastoma displaying intratumoral heterogeneity. Neuropath Appl Neuro. 2024: e12945. PMID: 38093348.
  35. Mahapatra S.A National Meeting for the American Federation for Medical Research: Decades in the Making. J Investig Med. 2024;15:10815589241229812. PMID: 38361422.
  36. Cheifetz IM, Dawkins-Henry OS, Kong M. et al.Characteristics and outcomes of children with SARS-CoV-2 respiratory failure: a matched cohort study. Intensive Care Med. Paediatr. Neonatal. 2024; 2(18).
  37. Cave C, Samano D, Sharma AM, Dickinson J, Salomon J, and Mahapatra S.Acute Respiratory Distress Syndrome: A review of ARDS across the life course. J Investig Med. 2024;72(8)798-818. PMID: 39092841.
  38. Perumal N, Gopalakrishnan P, Burkovetskya M, Doss D, Dukkapatti S, Kanchan RK, Mahapatra S. Nuclear Factor I/B: Duality in Action in Cancer Pathophysiology. Cancer Lett. 2025; 28:609:217349. PMID:
  39. Maurya SK, Jaramillo-Gómez JA, Rehman AU, Gautam SK, Fatima M, Khan MA, Zaidi MAA, Khan P, Anwar L, Alsafwani ZW, Kanchan RK, Mahiuddin S, Rothuraju R, Vengoji R, Venkata RC, Natarajan G, Bhatia R, Atri P, Perumal N, Chaudhary S, Lakshaman I, Mahapatra S, Talmon GA, Cox JL, Smith LM, Santamria-Barria JA, Ganti AK, Siddiqui JA, Cittelly DM, Batra SK, Nasser MW. Mucin5AC promotes breast cancer brain metastasis through cMET/CD44v6. Clinal Cancer Research 2025. PMID: 39760691.
  40. Wiley Z, Mahapatra S, Agarwal G, Baer S, Bukhari S, Cervantes J, Correa R, Crosby S, Das S, De Leon J, Dickinson J, Dutcher JP, Fuchs S, Hahn A, Ioachimescu O, Kandiah S, Kim MS, Kotwal A, McCallum R, Muzny CA, Sueblinvong V, Salomon J, Stevenson D, Suvannasankha A, Tague LK, Trandafirescu T, Wiernik PH. The American Federation for Medical Research Maintains Commitment to Decades of Support of Vaccine and Vaccination Research to Improve Public Health.J Investig Med. 2025 [in press]

 

Books and Book Chapters

  1. Neet, K. E., Mahapatra, S. and Mehta, H. (2011) Selectivity of cell signaling in the neuronal response based on NGF mutations and peptidomimetics in the treatment of Alzheimer’s Disease. In Suzanne De La Monte (Ed.), Alzheimer’s Disease pathogenesis-core concepts, shifting paradigms, and therapeutic targets (pp. 243-272). Rijeka, Croatia: Intech. doi:10.5772/21042.
  2. Mahapatra, S., Luna, N., Basnet, S. Pediatric Critical Care. St. Petersburg: StatPearls Publishing, LLC, 2017. https://www.statpearls.com
  3. Peniston, F.H., Mahapatra S. (2017) Acute Respiratory Distress Syndrome (ARDS). In StatPearls. Treasure Island (FL): StatPearls Publishing. PMID: 28613773.
  4. Mahapatra, S., Heffner, A. (2017) Shock, Septic (Sepsis). In StatPearls. Treasure Island, Florida: StatPearls Publishing; 2017. PMID: 28613689.
  5. Mahapatra, S., Challagundla K. (2017) Cancer, Neuroblastoma. In StatPearls. Treasure Island, Florida: StatPearls Publishing. PMID: 28846355.
  6. Mahapatra, S., Amsbaugh, M. (2017) Cancer, Medulloblastoma. In StatPearls. Treasure Island, Florida: StatPearls Publishing. PMID: 28613723.
  7. Mahapatra, S., Perumal, N.K. (2021) Targeting subgroup-specific cancer epitopes for effective treatment of pediatric medulloblastoma. In Batra and Poonsamy (Ed.), Gene Regulation & Therapeutics for Cancer. Science Publishers/CRC Press. eBook ISBN: 9781315200194. DOI: https://doi.org/10.1201/b22128.

 

Audiovisual materials

  1. Mahapatra, S. (2014). Well Child Checklist. In AgileMD for Apple iOS (Version 2.4.1) [Mobile application software]. Retrieved from http://www.agilemd.com/
  2. Mahapatra, S. (2019) Are Amyloid Peptides Potential Therapeutics for Sepsis? [Audiobook]. Retrieved from https://soundcloud.com/scipodglobal/are-amyloid-peptides-potential-therapeutics-for-sepsis
  3. Mahapatra, S. (2021, Aug 1). Shock: Part 1. [Audio podcast]. In Healing Hearts: Empowering Pediatric Critical Care Providers. Children’s Hospital and Medical Center. https://podcasters.spotify.com/pod/show/childrensomaha/episodes/Shock-Part-1-e27f2k5
  4. Mahapatra, S. (2021, Sept 1). Septic Shock: Part 2. [Audio podcast]. In Healing Hearts: Empowering Pediatric Critical Care Providers. Children’s Hospital and Medical Center. https://podcasters.spotify.com/pod/show/childrensomaha/episodes/Septic-Shock-Part-2-e27f2j0
  5. Mahapatra, S. (2021, Sept 15). Other Shock States: Part 3. [Audio podcast]. In Healing Hearts: Empowering Pediatric Critical Care Providers. Children’s Hospital and Medical Center. https://podcasters.spotify.com/pod/show/childrensomaha/episodes/Other-Shock-States-Part-3-e27f2kb

 

Other

  1. Mahapatra, S., Maharaj, S. (2008). Medical Student Service Project Award, The Chicago Medical School at Rosalind Franklin – Health care: A right that must be shared by all. The Pharos, 71(1), 53-55.
  2. Mahapatra, S. (2020). Sammy. Synapses, 4(1),10-11. Retrieved from https://online.pubhtml5.com/mxlq/ehsi/   
  3. Mahapatra, S. (2020). A Medical Student Opens His Eyes. Synapses, 4(1). 34. Retrieved from https://online.pubhtml5.com/mxlq/ehsi/
  4. Mahapatra, S. (2020). Carpe Diem. Synapses, 4(1). 62. Retrieved from https://online.pubhtml5.com/mxlq/ehsi/
  • Outstanding Platform Presentation, 93rd Illinois State Academy of
    Sciences, Macomb, IL (2001)
  • Outstanding Poster and Travel Award to the 34th Annual Midwest Student Biomedical Research Forum, Omaha, NE (2002)
  • Outstanding Poster and Travel Award to the 21st Annual National MD/PhD Student Conference, Keystone, CO (2006)
  • Travel Award to the 36th Annual Society for Neuroscience Meeting, Atlanta, GA (2006)
  • ASBMB Travel Award to the 2007 Experimental Biology Meeting, Washington D.C. (2007)
  • Chicago Medical School Board of Trustees Scholarship Award (highest G.P.A. in clinical sciences) (2009)
  • Chicago Medical School Dean’s Community Service Award (2009)
  • Leonard P. Tow Humanism in Medicine (2009)

  • ROSE (Recognition of Service Excellence) Recipient for June and October (2010)

  • HeadStart Volunteer Award (2011)

  • HeadStart Volunteer Award (2012)
  • Excellence in Teaching, Arnold P. Gold Foundation (2012)
  • Humanism in Medicine and Excellence in Teaching Award (2012)
  • Division of Pediatric Critical Care Medicine Respect Award (2013)
  • Inpatient Fellow of the Year, Lucile Packard Children’s Hospital (2015)
  • Travel Award, Western Society for Clinical Investigation (2015)

  • SPOTlight (Special Performance Observed Today) Award Recipient for March, May and December (2016)

  • Young Investigator Coaching Program, Society for Pediatric Research (2017)
  • Top 10 Abstract, American Academy of Pediatrics Society for Critical Care (2017)

  • SPOTlight (Special Performance Observed Today) Award Recipient for July (2018)

  • UNeMED New Innovation Contributor, UNMC (2018, 2022, 2024)
  • Travel Award, Team Jack Brain Tumor Foundation (2020)
  • NIH/NICHD K12 Recipient (2021)
  • K Award, Midwest Clinical and Translational Research Meeting (2021)

  • SPOTlight (Special Performance Observed Today) Award Recipient for July (2021)

  • NIH/NCI Loan Repayment Award (2022)
  • Invited Speaker at Annual RFUMS Convocation (2022)

  • Sunshine Award for Patient Care Recipient for April, September, and December (2023)

  • Oral Abstract Award at the Midwest Clinical and Translational Research Meeting (2023)
  • Hobart E. Wiltse, MD, PhD Excellence in Medical Education Award (2023)
  • Helping Hands Award for Patient Care Excellence (2024)
  • Abstract Award Winner, Children's Brain Tumor Network (2024)
  • UNeMed New Invention Contributor: Identification of Artesunate as a Potential Anti-Cancer Agent for Group 3 Medulloblastoma (2024)

Local

  1. Synthesis of a Survival-selective Nerve Growth Factor Mutant Protein, Department of Neuroscience Retreat, Rosalind Franklin University of Medicine and Sciences, June 2007.
  2. Health Care Issues of Sexual Minority Youth, 19th Annual Pediatric Update Faculty, Stanford, CA, July 2011.
  3. Health Care Issues of Sexual Minority Youth, 20th Annual Pediatric Update Faculty, Stanford, CA, July 2012.
  4. Pediatric Acute Respiratory Distress Incidence and Epidemiology, 3rdAnnual Pediatric Respiratory and Sleep Symposium, Omaha, NE, June 2017.
  5. Elucidating the Role of Tumor Suppressor Genes on Chromosome 17p13.3 in non-SHH/WNT MB, Pediatric Cancer Research Group Seminar, University of Nebraska Medical Center, February 2017.
  6. MiR-1253, a Putative Tumor Suppressor Gene in Medulloblastoma, Cancer Genes & Molecular Regulation Talk, University of Nebraska Medical Center, March 2018.
  7. Identification of Tumor Suppressor Genes on chromosomes 17p13.3 in non-SHH/WNT subgroup MB, Pediatric Cancer Research Symposium, University of Nebraska Medical Center, September 2018.
  8. Medulloblastoma: Past Misconceptions, Present Challenge, and Future Promise, Buffet Cancer Center Grand Rounds, University of Nebraska Medical Center, February 2019.
  9. Mir-212 Functions as a Novel Tumor Suppressor in Group 3 Medulloblastoma via Targeting NFIB, Cancer Genes & Molecular Regulation Talk, University of Nebraska Medical Center, March 2020.
  10. Pediatric Sepsis Recognition and Treatment, Department of Pediatrics Grand Rounds, Children’s Nebraska, September 2020.
  11. A Critical Access Hospital Perspective: Pediatric Patients, COVID-19 & MIS-C, Simulation In Motion Nebraska, University of Nebraska Medical Center (virtual), December 2020.
  12. Deciphering Cytogenetic and Molecular Mechanisms Triggering Pediatric Group 3 Medulloblastomas, Department of Biochemistry and Molecular Biology Seminar, University of Nebraska Medical Center (virtual), January 2021.
  13. Medulloblastoma Collaborative, Pediatric Cancer Research Consortium, University of Nebraska Medical Center, September 2021.
  14. Ferroptosis Evasion Characterizes Tumor Aggressiveness in Pediatric Group 3 Medulloblastomas, Child Health Research Institute Seminar, University of Nebraska Medical Center, February 2022.
  15. Medulloblastoma Collaborative Annual Update, Pediatric Cancer Research Consortium, University of Nebraska Medical Center, August 2022.
  16. The NIH Loan Repayment Program: How the NIH Can Work For You, Child Health Research Institute Seminar, University of Nebraska Medical Center, September 2022.
  17. Repressing ABCB7 Potentiates Cisplatin Toxicity in Group 3. Medulloblastomas by Augmenting Ferroptosis, Annual Child Health Research Institute Research Symposium, Children’s Nebraska, November 2022.
  18. Deciphering Novel Molecular Mechanisms Triggering Pediatric Group 3 Medulloblastomas, Biomedical Sciences Department Seminar, Creighton University, December 2022.
  19. From Barley to Brains: Lessons Learned on my Path to Independence, Annual Child Health Research Institute Research Symposium Keynote Address, Children’s Nebraska, May 2023.
  20. Deciphering Molecular Mechanisms Triggering Pediatric Group 3 Medulloblastomas, Midwest Radiation Oncology Symposium, University of Nebraska Medical Center, August 2023.
  21. Pediatric Sepsis Recognition and Treatment, Department of Pediatrics Grand Rounds, Children’s Nebraska, September 2023.
  22. The Pediatric Brain Tumor Collaborative (formerly the Medulloblastoma Collaborative) Annual Update, Pediatric Cancer Research Consortium, University of Nebraska Medical Center, August 2023.
  23. From Barley to Brains: Lessons Learned on my Path to Independence, Pediatric Interest Group Talk, University of Nebraska Medical Center, November 2023.
  24. Pediatric Brain Tumors in Nebraska: Leveraging the Power of Team Science to Address this Scourge, Department of Pediatrics Grand Rounds, Children’s Nebraska, NE, April 2024.
  25. The Nebraska Children’s Brain Tumor Collaborative (formerly the Pediatric Brain Tumor Collaborative), Pediatric Cancer Research Consortium, University of Nebraska Medical Center, August 2024.
  26. The Brain Tumor Working Group, Brain Tumor Working Group Mini Summit, University of Nebraska Medical Center, March 2025.
  27. Leveraging Iron Overload to Induce Ferroptosis as a Novel Treatment Strategy for Pediatric Medulloblastomas, Biochemistry and Molecular Biology Noon Seminar, University of Nebraska Medical Center, March 2025

Regional/National

  1. Effects of Heat Shock on the Ratio of Membrane-Bound to Free Alpha-amylase-Translating Polysomes, 93rd Illinois State Academy of Sciences (1st place winner), Macomb, IL, April 2001.
  2. Exploring the Anti-inflammatory Effect of the Amyloidogenic Hexapeptide, Amylin28-33, in Sepsis, 2016 Western Regional Meeting, Carmel, CA, January 2016.
  3. Exploring the Anti-inflammatory Effect of the Amyloidogenic Hexapeptide, Amylin28-33, in Sepsis, 45th Critical Care Congress (Research Spotlight Talk), Orlando, FL. February 2016.
  4. Amyloidogenic Hexapeptide, Amylin, Attenuates Inflammation and Acute Lung Injury in Murine Sepsis, 46th Critical Care Congress (Research Spotlight Talk), Honolulu, HA, January 2017.
  5. Amyloidogenic Hexapeptide, Amylin, Attenuates Inflammation and Acute Lung Injury in Murine Sepsis, 24th American Academy of Pediatrics, Pediatric Critical Care Colloquium (Top 10 Abstract), Chicago, IL, September 2017.
  6. Pediatric Acute Respiratory Distress Incidence and Epidemiology, 40th Annual Lung Conference of the Iowa Society for Respiratory Care, Des Moines, IA, April 2018.
  7. Pediatric Acute Respiratory Distress Incidence and Epidemiology, 40th Anniversary Conference of the Nebraska Society for Respiratory Care, Nebraska City, NE, May 2019.
  8. Medulloblastoma: Past Misconceptions, Present Challenge, and Future Promise, Department of Neuroscience Seminar, University of Toledo School of Medicine, Toledo, OH, February 2020.
  9. Retrospective Analysis of Feeding Practices and Outcomes in Bronchiolitis Patients on NIPPV, 49th Critical Care Congress (Research Spotlight Talk), Orlando, FL, February 2020.
  10. E-cigarette/Vaping Associated Lung Injury (EVALI), Nebraska State Education Association Lunch and Learn with Senators at the Capitol, Lincoln, NE, February 2020.
  11. Case Presentation: COVID-19 Testing, AAP COVID-19 Pediatric Emergency Readiness & Response ECHO Session 5, Omaha, NE (virtual), May 2020.
  12. MiR-212 Functions as a Tumor Suppressor Gene in Group 3 Medulloblastoma via Targeting NFIB, 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan (virtual), December 2020.
  13. Clinical Characteristics Distinguishing Bronchiolitis Patients Requiring Mechanical Ventilation, 50th Critical Care Congress (virtual), January 2021.
  14. Mining the Transcriptome to Unravel Pediatric Medulloblastoma Pathophysiology, Annual Bioinformatics Symposium, University of Toledo School of Medicine (virtual), February 2021.
  15. Deciphering Cytogenetic and Molecular Mechanisms Triggering Pediatric Group 3 Medulloblastomas, Biannual Pediatric Neuro-Critical Care Research Group Meeting (virtual), March 2021.
  16. MiR-1253 Potentiates Cisplatin Cytotoxicity by Targeting ABCB7 and Promoting Ferroptosis, Biannual Pediatric Neuro-Critical Care Research Group Meeting (virtual), October 2021.
  17. MiR-1253 Potentiates Cisplatin Response in Group 3 Medulloblastomas Through Ferroptosis, National PCCTSDP Annual Retreat (K12 Awardee Talk), Deer Valley, UT, November 2021.
  18. Exploring and Exploiting Novel Oncogenic Mechanisms in Pediatric Medulloblastomas, Department of Neurology Grand Rounds, University of Toledo School of Medicine (virtual), February 2022.
  19. Ferroptosis Evasion Characterizes Tumor Aggressiveness in Pediatric Group 3 Medulloblastomas, Midwest Clinical and Translational Research Meeting, Chicago, IL, March 2022.
  20. Case Review on Diabetic Ketoacidosis, Emergency Nurses Association Meeting (virtual), November 2022.
  21. Repressing ABCB7 Potentiates Cisplatin Toxicity in Aggressive Medulloblastomas Through Heightened Ferroptosis, National PCCTSDP Annual Retreat (K12 Awardee Talk), Deer Valley, UT, November 2022.
  22. From Barley to Brains: Lessons Learned on my Path to Independence, Annual MD, PhD Retreat, University of Toledo School of Medicine (virtual), August 2023.
  23. Targeting Iron Metabolism as a Novel Mechanism for Aggressiveness in Pediatric Medulloblastoma, Hematology and Oncology Division Seminar, University of Colorado, Denver, CO, October 2023.
  24. Repressing ABCB7 Potentiates Cisplatin in Medulloblastomas by Triggering Ferroptosis, National PCCTSDP Annual Retreat (K12 Awardee Talk), Deer Valley, UT, November 2023.
  25. From Barley to Brains: Lessons Learned on my Path Towards Independence, Western Medical Research Conference, Carmel, CA, January 2024.
  26. Inducing Iron Overload and Ferroptosis as Novel Treatment Strategies for Pediatric Medulloblastomas, Olson Lab Meeting, University of Washington (virtual), March 2024.
  27. From Barley to Brains: Lessons Learned on my Path Towards Independence, Career Development Talk, Midwest Clinical and Translational Research Meeting, Chicago, IL, April 2024.
  28. Triggering Ferroptosis by Targeting ABCB7 Can Potentiate Cisplatin Action in Pediatric Group 3 Medulloblastomas, Midwest Clinical and Translational Research Meeting (Oral Abstract Award Winner), Chicago, IL, April 2024.
  29. Inducing Iron Overload and Ferroptosis as Novel Treatment Strategies for Pediatric Medulloblastomas, Pediatric Neurooncology Consortium Meeting (virtual), July 2024.
  30. Inducing Iron Overload and Ferroptosis as Novel Treatment Strategies for Pediatric Medulloblastomas, Pediatric Brain Tumor Consortium Meeting (virtual), September 2024.
  31. Inducing Iron Overload Potentiates Cisplatin Cytotoxicity in Aggressive Medulloblastomas by Triggering Ferroptosis, National PCCTSDP Annual Retreat (K12 Awardee Talk), Deer Valley, UT, November 2024.
  32. Repurposing an Antimalarial Drug for Pediatric Medulloblastoma, Pediatric Brain Tumor Consortium, St. Louis, MO, May 2025.
  • Sigma Xi, 1999 (present)
  • Phi Beta Kappa (2001 – present)
  • Alpha Omega Alpha (AOA) (2008 – present)
  • Gold Humanism Honors Society (GHHS) (2009 – present)
  • American Academy of Pediatrics (AAP) (2009 – present)
  • Society for Critical Care Medicine (SCCM) (2012 – present)
  • American Federation for Medical Research (AFMR) (2015 – present)
  •  Society for Pediatric Research (SPR) (2016 – present)
  • American Academy of Pediatrics, Society on Critical Care (AAP SOCC) (2016 – present)
  • Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) (2016 – present)
  • American Academy for Cancer Research (AACR) (2017 – present)
  • Society for Neuro-Oncology (SNO) (2018 – present)
Division

University of Nebraska Medical Center

Department of Pediatrics

Pediatric Critical Care Division

8200 Dodge Street

Omaha, NE 68114

four people in lab looking at computer
Mahapatra Lab

Learn about the research projects of Dr. Sidharth Mahapatra's lab.

Dr. Mahapatra's Collective Research Groups

Brain Tumor Research Group (group leader)

Pediatric Cancer Research Group (co-champion)

Nebraska Children’s Brain Tumor Collaborative