Sidharth Mahapatra, MD, PhD

Academic Appointments
mahapatra.jpgAssistant Professor, Department of Pediatrics, University of Nebraska Medical Center
Assistant Professor, Department of Biochemistry, University of Nebraska Medical Center
Assistant Professor, Department of Pediatrics, Creighton University

Main Practice Location
Children’s Hospital & Medical Center
8200 Dodge Street 
Omaha, NE 68114

Lab/Academic Office
University of Nebraska Medical Center
601 South Saddle Creek Road, DRC 1, Rm 7046
Omaha, NE 68106

MD & PhD
Rosalind Franklin University of Medicine and Sciences, North Chicago, IL

Residency & Fellowship
Lucile Packard Children's Hospital, Stanford School of Medicine, Palo Alto, CA

Career Interests: As a pediatric intensivist with an interest in neurocritical care working in a state with a punctuated incidence of pediatric brain tumors, I aspire to carve my academic niche studying pediatric medulloblastomas (MB), the most common malignant brain tumor of childhood. Serving as an intersection for my training in molecular neurobiology, my strong interest in translational science, and my burgeoning expertise in pediatric critical care medicine, I hope to significantly impact the long term survivorship of patients with high-risk medulloblastomas, who suffer high relapse rates and mortality. To this end, my lab’s long-term objectives are:

  1. To define pathophysiologicevents triggering neoplastic transformation by studying genetic events targeting chromosome 17p13.3
  2. To generate preclinical mouse models, including orthotopic, spontaneous and patient-derived xenografts, using our understanding of pathophysiology
  3. To generate novel anti-neoplastic agents using cutting-edge bioinformatics tools that may be tested in our genetically-engineered mouse models

I am also an active member of the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI). We recently participated in a multi-center study on Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE). We are now engaged in the Prone and Oscillator in Pediatrics Clinical Trial (PROSpect) aimed at studying treatment strategies in severe PARDS.

Active Grants
PCCTSDP K12 Scholar Award (K12HD047349)                            01/01/2021 – 12/31/2023
Project Title: MiR-1253 potentiates cisplatin response in group 3 medulloblastoma through ferroptosis

Team Jack Brain Tumor Foundation Award                              01/01/2020 – 12/30/2022
Project Title: Chemosensitization of non-SHH/WNT medulloblastoma is regulated by miR-1253

American Cancer Society Institutional Research Grant               08/01/2020 – 07/31/2021
Project Title: Exploring the oncogenic properties of NFIB in group 3 medulloblastoma 

LB506 (DHHS)                                                                                 07/01/2020 – 06/30/2021
Project Title: Elucidating the oncogenic role of NFIB in group 3 medulloblastoma

LB606 (DHHS)                                                                                 07/01/2020 – 06/30/2021
Project Title: NFIB’s role in medulloblastoma stem cell renewal

Past Grants
Edna Ittner Pediatric Grant                                                            12/01/2019 – 11/30/2020
Project Title: Chemosensitization of Group 3 MB is Regulated by miR-1253

Pediatric Cancer Research Center Grant                           06/01/2017 – 05/30/2020
Project Title: Identification of Tumor Suppressor Genes on Chromosome 17p13.3 in non-SHH/WNT Subgroup MB

Full Publication List 

Team Jack Brain Tumor Foundation Award Video

Commentary on Clinical Impact of COVID-19

Interview with Prospective MD, PhD Students at Knox College