Eric Peeples Lab
The Newborn Brain Injury Lab led by Dr. Peeples seeks to better understand the underlying cell signaling and pathophysiology occurring after neonatal hypoxic-ischemic brain injury in order to design novel neuroprotective interventions. The bench research from our lab currently centers around two areas: 1) altering the dysregulated microRNA signaling that occurs after injury and 2) investigating the metabolic (specifically sterol-related) changes occurring after injury in order to identify targets for intervention.
Clinically, our lab is also leading local and regional quality improvement efforts to improve the care of infants with hypoxic-ischemic brain injury throughout Nebraska, South Dakota and Iowa.
Lab Contact Information
Current Members
Amanda Johnason
MD/PhD Student
Rajnish Yadav, PhD
Postdoctoral Research Associate
Lab Features
- Newborn brain injury & neuroprotection
- MicroRNAs
- Brain sterol synthesis and metabolism
- Hypoxic-ischemic encephalopathy
- Intraventricular/periventricular hemorrhage
- Neonatal brain imaging and neuromonitoring
- Cell transfection
- ELISA
- Immunohistochemistry
- Polymerase chain reaction
- Pre-clinical models of hypoxia-ischemia
- Primary cell and cell line culture
- RNA Extraction
- Western blot
- Child Health Research Institute