The Newborn Brain Injury Lab led by Dr. Peeples seeks to better understand the underlying cell signaling and pathophysiology occurring after neonatal hypoxic-ischemic brain injury in order to design novel neuroprotective interventions. The bench research from our lab currently centers around two areas: 1) altering the dysregulated microRNA signaling that occurs after injury and 2) investigating the metabolic (specifically sterol-related) changes occurring after injury in order to identify targets for intervention.
Clinically, our lab is also leading local and regional quality improvement efforts to improve the care of infants with hypoxic-ischemic brain injury throughout Nebraska, South Dakota and Iowa.
Areas of Interest
Newborn brain injury & neuroprotection
Brain sterol synthesis and metabolism
Neonatal brain imaging and neuromonitoring
January, 2022: Newborn Brain Injury Lab publication “Temporal brain microRNA expression changes in a mouse model of neonatal hypoxic-ischemic injury” selected for Editor’s Focus in Pediatric Research
November, 2021: Dr. Peeples successfully defended his Ph.D. dissertation entitled “The role of microRNAs in the pathophysiology of neonatal hypoxic-ischemic brain injury”
September, 2021: Dr. Peeples selected for Early Career Investigator spotlight in January, 2022 issue of Pediatric Research
June, 2021: Newborn Brain Injury Lab publication “Cholesterol metabolism and brain injury in neonatal encephalopathy” selected for Editor’s Focus in Pediatric Research
June, 2021: Amanda Dave, MD, pediatric resident working with Newborn Brain Injury lab, receives George Miyzakai research award for graduating pediatric resident demonstrating excellence in research.
June, 2021: Newborn Brain Injury lab members present virtual poster "Effects of neonatal hypoxic-ischemic brain injury on brain sterol synthesis and metabolism" at 12th Hershey Conference on Developmental Brain Injury.
May, 2021: Creighton summer research student Jeffery Kepple awarded first prize among medical students for presentation at CHRI Pediatric Research forum ("Conjugated Hyperbilirubimenia in Infants with Trisomy 13 and 18") and pediatric resident Amanda Dave receives first place among residents/fellows ("Evaluation of brain cholesterol metabolism after neonatal hypoxic-ischemic brain injury") for work done with the Newborn Brain Injury lab.
CHRI Scholars Program, CHRI Mini Grants, COPIC Medical Foundation