University of Nebraska Medical Center
University of Nebraska Medical Center

Laboratory of James Ahodantin, Msc, PhD

Research Interests

My research focuses on how viral infections and metabolic dysfunction drive chronic liver disease. My lab investigates the interactions among HBV, HIV, metabolic stress, and alcohol exposure in the development of metabolic dysfunction-associated steatohepatitis (MASH), alcohol-associated liver disease (ALD) and hepatocellular carcinoma (HCC). We use advanced in vitro systems and mouse models to define the roles of innate immune cells—particularly plasmacytoid dendritic cells (pDCs) and macrophages—in regulating inflammation, fibrosis, and liver cancer. Our long-term goal is to identify immune and metabolic pathways that can be targeted to prevent or reverse chronic liver disease progression.

 

 Ongoing Projects

  • Mechanisms of HEPLISAV-B Treatment to Overcome HBV-Induced Immune Tolerance
  • Role of Plasmacytoid Dendritic Cells in Autoimmune Hepatitis
  • Immunomodulatory Role of lipids and Plasmacytoid Dendritic Cells in MASH and HCC
  • Effect of Alcohol on HIV- and HBV-Induced Liver Disease

Lab Personnel

Ashwin Barath Vaidhyalingham, MS

Research Technologist I

Akhilesh Kode

Summer Student 2026

Dhyey Patel

Summer Student 2026

Funding

  • American Liver Foundation 2025-Pilot Research Award

2026-2029   

Budget: $300,000

2025-2028

Budget: Confidential.

2026-2027

Budget: $25,000.

2025-2026   

Budget: $50,000.