Professor, Department of Surgery
Professor, Department of Genetics, Cell Biology and Anatomy (courtesy)
Director, Center for Advanced Surgical Technology (CAST)
University of Nebraska Medical Center
Phone: 402-559-7733
Fax: 402-559-7750
Staff Surgeon
VA Nebraska Western-Iowa Health Care System
Surgery 112, VA Medical Center
4101 Woolworth Avenue
Omaha, NE 68105
Phone: 402-995-5371
Curriculum Vitae
Graduate:
Case Western Reserve University School of Medicine, Cleveland, OH
Residency:
Medical College of Wisconsin, Milwaukee, WI
Fellowship:
Minimally Invasive Surgery at the Medical College of Wisconsin, Milwaukee, WI
Wound Healing at the University of Texas Southwestern Medical School, Dallas, TX
Board Certification:
American Board of Surgery
Academic Appointments:
Professor of Surgery
Professor, Department of Genetics, Cell Biology and Anatomy (courtesy)
Clinical Interests:
Minimally Invasive Surgery
Abdominal Wall Surgery
Antireflux Surgery
Gastrointestinal Malignancy
Biliary Disease
Technology Interests:
Surgical Instrument Development (Minimally Invasive and Open Surgery)
Synthetic Surgical Mesh for Hernia Surgery
Hemostatic Devices for Emergency and Elective Surgery
Research Interests:
- Cancer. The primary focus in our laboratory is the development of novel large animal models of solid epithelial tumors, including pancreatic and breast, with plans to include rectal cancer. Swine are being utilized for this purpose. Validated large animal models of cancer will have numerous advantages over traditional small animal (mouse) models.
- Regenerative Medicine. The emphasis here is on the use of large animal models to develop regenerative therapies, including stem-cell based therapies, for treatment of conditions involving tissue loss and/or organ dysfunction. The general belief is that the biology and physiology of humans will be more accurately reflected by large animal models (such as in swine) than by the traditional rodent models. Therefore, the use of large animal models in regeneration research should result in more efficient development of regenerative therapies. Current areas of interest include biomaterials for tissue replacement and cell-based therapies for ischemic skeletal muscle.
- Hemostasis. Unsolved problems in severe traumatic hemorrhage include (1) noncompressible torso hemorrhage and (2) uncontrolled junctional hemorrhage. Approaches to these problems being developed in our collaborative research program include the use of expansile biocompatible foam, recombinant human clotting proteins, and nanoengineered biomaterials.
- Wound Healing. Study of human dermal fibroblast biology focuses on signaling pathways involved in senescence, death, proliferation, migration, and extracellular matrix reorganization by this multi-purpose cell of healing.
Most Recent Publications:
- Poblete Jara C, Wang O, do Prado PT, Ismail A, Fabian FM, Carlson MA, et al. Novel Fibrin-Fibronectin Matrix Accelerates Mice Skin Wound Healing. Bioact Mater. 5(4):949-962. 2020 July. Abstract
- Patel NS, Bailey K, Lazenby AJ, Carlson MA. Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig: preliminary report. bioRxiv. [Online ahead of print] 2020 June. Abstract
- Chen S, John JV, McCarthy A, Carlson MA, Li X, Xie J. Fast Transformation of 2D Nanofiber Membranes into Pre-molded 3D Scaffolds with Biomimetic and Oriented Porous Structure for Biomedical Applications. Appl Phys Rev. 7:021406. 2020 June. Abstract
- Gao Y, Patel NS, Aravind S, Fuglestad M, Ungar JS, Carlson MA, et al. Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow. J Surg Res. 249:168-179. 2020 May. Abstract
- Poblete Jara C, Wang O, do Prado PT, Ismail A, Fabian FM, Carlson MA, et al. Three-Dimensional (3D) Fibronectin Nano-Array Presented on Fibrin Matrix Accelerates Mice Skin Wound Healing. bioRxiv. [Online ahead of print] 2020 May. Abstract
- Wei L, Wu S, Shi W, Aldrich A, Kielian T, Carlson MA, et al. Large-scale and rapid preparation of nanofibrous meshes and their application for drug-loaded multilayer mucoadhesive patch fabrication for mouth ulcer treatment. ACS Appl Mater Interf. 11(32):28740-28751. 2019 August. Abstract
- Su Y, Wang H, Mishra B, Lakshmaiah Narayana J, Jiang J, Carlson MA, et al. Nanofiber Dressings Topically Delivering Molecularly Engineered Human Cathelicidin Peptides for Treatment of Biofilms in Chronic Wounds. Mol Pharm. 16(5):2011-2020. 2019 May. Abstract
- Gao Y, Patel NS, Aravind S, Fuglestad M, Ungar JS, Carlson MA, et al. Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow. bioRxiv. [Online ahead of print] 2019 May. Abstract
- Chen S, Wang H, McCarthy A, Yan Z, Kim H, Carlson MA, et al. Three-dimensional objects consisting of hierarchically assembled nanofibers with controlled alignments for regenerative medicine. Nano Letters. 19(3): 2059. 2019 March. Abstract
- Bailey KL, Carlson MA. Porcine Models of Pancreatic Cancer. Front Oncol. 9:144. 2019 March. Abstract
- Lin H, Li Q, Du Q, Wang O, Wang Z, Carlson MA, et al. Integrated generation of induced pluripotent stem cells in a low-cost device. Biomaterials. 189:23-36. 2019 January. Abstract
- Ismail A, Fabian F, Wang O, Lei Y, Carlson MA, Burgess WH, et al. The isolation of a γγ’ fibrinogen:fibronectin mixture that forms a novel polymeric matrix. Proc Biochem. 75:257-65. 2018 December. Abstract
- Wang O, Ismail A, Fabian FM, Lin H, Li Q, Carlson MA, et al. A totally recombinant fibrin matrix for mesenchymal stem cell culture and delivery. J Biomed Mater Res A. 106(12):3135-3142. 2018 December. Abstract
- Yanala UR, Johanning JM, Pipinos II, High RR, Larsen G, Carlson MA, et al. Fluid administration rate for uncontrolled intraabdominal hemorrhage in pigs. PLoS ONE. 13(11):e0207708. 2018 November. Abstract
- Chen S, Carlson MA, Zhang YS, Y Hu, Xie J. Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis. Biomaterials. 179:46-59. 2018 October. Abstract
For additional publications, visit PubMed