Shaheed Merani, MD, PhD, FRCS(C), FACS

Dr. Merani

Associate Professor of Surgery
University of Nebraska Medical Center
983285 Nebraska Medical Center
Omaha, NE 68198-3285, USA
Phone: 402-559-6730
Fax: 402-559-3434

Graduate: University of Alberta
Fellowship: University Nebraska Medical Center
Board Certification:

American Board of Surgery, Royal College of Physicians and Surgeons of Canada

Academic Appointment:

2017 –  University of Nebraska Medical Center. 

Special Interests:

Clinical interest in liver and pancreatic surgery as well as liver and intestinal transplantation. Research focus on the clinical outcomes of intestinal transplantation, specifically exploring strategies to optimize graft function and patient survival.


  1. Kidney injury and status 1 liver transplantation: Outcomes, kidney function, and listing for kidney transplantation

    Cloonan, D. J., Cloonan, M. R., Westphal, S. G., Dageforde, L. A. & Merani, S.Apr 2023
  2. Kidney injury and status 1 liver transplantation: Outcomes, kidney function, and listing for kidney transplantation

    Cloonan, D. J., Cloonan, M. R., Westphal, S. G., Dageforde, L. A. & Merani, S., Feb 13 2023
  3. Unusual dMMR Phenotype Locally Advanced Pancreatic Ductal Adenocarcinoma with Germline and Somatic BRCA2 Mutation in a Jehovah Witness Patient

    Copur, M. S., Tun, S. M., Vargas, L.Merani, S., Wedel, W., Duckert, R., Horn, A., Lintel, N., Herold, D. & Lavudi, S., Mar 2023
  4. A North American single-center experience with liver transplantation using thoracoabdominal normothermic regional perfusion for donation after circulatory death

    Merani, S.Urban, M.Um, J. Y.Maskin, A.Vargas, L. M., Castleberry, A. W., Mercer, D. F., Grant, W. & Langnas, A. N., Feb 2022,
  5. Cholecystectomy prior to short bowel syndrome does not alter nutritional prognosis

    Thompson, J. S.Rochling, F. A., Lyden, E., Merani, S.Vargas, L. M., Grant, W. J., Langnas, A. N. & Mercer, D. F., 2022
  6. Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial

    Markmann, J. F., Abouljoud, M. S., Ghobrial, R. M., Bhati, C. S., Pelletier, S. J., Lu, A. D., Ottmann, S., Klair, T., Eymard, C., Roll, G. R., Magliocca, J., Pruett, T. L., Reyes, J., Black, S. M., Marsh, C. L., Schnickel, G., Kinkhabwala, M., Florman, S. S., Merani, S., Demetris, A. J., & 15 others, Mar 2022
  7. Liver transplantation as a new standard of care in patients with perihilar cholangiocarcinoma? Results from an international benchmark study

    Breuer, E., Mueller, M., Doyle, M. B., Yang, L., Murad, S. D., Anwar, I. J., Merani, S., Limkemann, A., Jeddou, H., Kim, S. C., López-López, V., Nassar, A., Hoogwater, F. J. H., Vibert, E., de Oliveira, M. L., Cherqui, D., Porte, R. J., Magliocca, J. F., Fischer, L., Fondevila, C., & 15 others, Nov 1 2022.
  8. Presentation of preclinical gastrointestinal anatomy via laparoscopic simulation

    McCumber, T. L.Mott, J. L.Merani, S. & Rochling, F. A., Oct 2022
  9. Successful lung transplantation with graft recovered after thoracoabdominal normothermic perfusion from donor after circulatory death

    Urban, M., Castleberry, A. W., Markin, N. W., Chacon, M. M., Strah, H. M., Um, J. Y., Berkheim, D., Merani, S. & Siddique, A., Jan 2022
  10. Thoracoabdominal Normothermic Perfusion in Donation After Circulatory Death

    Urban, M., Castleberry, A. W., Duncan, K. F.Markin, N. W., Chacon, M. M., Siddique, A.Merani, S., Robertson, R., Fristoe, L. & Um, J. Y., Jun 2022.
  11. Immune function and infectious complications in children with jejunoileal atresia

    Prachuapthunyachart, S., Merani, S., Cloonan, M., Langnas, A. N.Quiros-Tejeira, R. E. & Vo, H. D., Mar 2021
  12. Increased Morbidity and Mortality of Patients with Non-cirrhotic Portal Vein Thrombosis After Abdominal and Pelvic Surgeries: a Study of the National Inpatient Sample 2002 to 2015

    Manatsathit, W., Patel, K., Enke, T., Sayles, H., Jophlin, L. L. & Merani, S., Aug 2021
  13. Not as Rare as Initially Described: Transplant Ureter Incarceration Within Inguinal Hernia. Two Cases, Literature Review, and Management Algorithm

    Merani, S., Aufhauser, D. D., Maskin, A. T., Mezrich, J. & Al-Adra, D., Sep 2021
  14. The impact of multi-organ transplant allocation priority on waitlisted kidney transplant candidates

    Westphal, S. G.Langewisch, E. D., Robinson, A. M., Wilk, A. R., Dong, J. J.Plumb, T. J.Mullane, R.Merani, S., Hoffman, A. L., Maskin, A. & Miles, C. D., Jun 2021
  15. Central diabetes insipidus unmasked by kidney transplantation: a case report and literature review

    Merani, S., Emuron, D., Westphal, S. & Hoffman, A., Sep 2020
  16. Hereditary vs familial pancreatic cancer: Associated genetic syndromes and clinical perspective

    Copur, M. S., Talmon, G. A., Wedel, W., Hart, J. D., Merani, S. & Vargas, L. M., Jun 2020
  17. Including colon in intestinal transplantation: a focus on post-transplant renal function – a retrospective study

    Ewald, C., Swanson, B. J.Vargas, L., Grant, W. J., Mercer, D. F.Langnas, A. N. & Merani, S., Feb 1 2020
  18. Pancreatic Neuroendocrine Tumor With Humoral Hypercalcemia and High Tumor PD-L1 Score

    Copur, M. S., Vargas, L., Wedel, W., Merani, S.Cushman-Vokoun, A. & Drincic, A., Dec 7 2020
  19. Viral enteritis in intestinal transplant recipients

    Servais, A. M., Keck, M., Leick, M., Mercer, D. F.Langnas, A. N., Grant, W. J., Vargas, L. M.Merani, S. & Florescu, D. F., Apr 1 2020
  20. Biliary cancer: Current multimodality treatment and future directions

    Copur, M. S., Merani, S. & Vargas, L. M., Sep 2019
  21. Double Obstruction Following Third Renal Transplant: A Case Report

    Anderson, B., Merani, S. & Maskin, A., Nov 2019
  22. Failure of abdominal wall closure after intestinal transplantation: Identifying high-risk recipients

    Cloonan, M. R., Fortina, C. A., Mercer, D. F.Vargas, L. M., Grant, W. J., Langnas, A. N. & Merani, S., Nov 1 2019
  23. Quality of follow-up: Systematic review of the research in bariatric surgery

    Switzer, N. J., Merani, S., Skubleny, D., Pelletier, J. S., Kanji, R., Shi, X., Birch, D. W., De Gara, C., Sharma, A. M., Gill, R. S. & Karmali, S., 2016
  24. Repeated metastasectomy in an adolescent with fibrolamellar hepatocellular carcinoma: A case report

    Merani, S. & Lees, G. M., May 2016
  25. Total pancreatectomy and autoislet transplant for chronic recurrent pancreatitis in a 5-year-old boy

    Merani, S., Razzak, R., Kin, T., Haqq, A., Huynh, H. & Shapiro, A. M. J., Oct 1 2016
  26. A prevascularized subcutaneous device-less site for islet and cellular transplantation

    Pepper, A. R., Gala-Lopez, B., Pawlick, R., Merani, S., Kin, T. & Shapiro, A. M. J., May 12 2015
  27. Perioperative factors predicting poor outcome in elderly patients following emergency general surgery: A multivariate regression analysis

    Lees, M. C., Merani, S., Tauh, K. & Khadaroo, R. G., Oct 1 2015
  28. Predictors of in-hospital mortality and complications in very elderly patients undergoing emergency surgery

    Merani, S., Payne, J., Padwal, R. S., Hudson, D., Widder, S. L., Khadaroo, R. G., Brisebois, R., Buttenschoen, K., Fathimani, K., Hamilton, S. M., Lees, G. M., McMullen, T. P. W., Patton, W., Wijngaarden-Stephens, M. V., Sutherland, J. D. & Williams, D. C., Jul 7 2014
  29. Research productivity of residents and surgeons with formal research training

    Merani, S., Switzer, N., Kayssi, A., Blitz, M., Ahmed, N. & Shapiro, A. M. J., Nov 1 2014
  30. A score predicting survival after liver retransplantation for hepatitis C virus cirrhosis

    Andres, A., Gerstel, E., Combescure, C., Asthana, S., Merani, S., Majno, P., Berney, T., Morel, P., Kneteman, N., Mentha, G. & Toso, C., Apr 15 2012
  31. Characterization of the transcriptome in isolated and transplanted mouse pancreatic islets: Associations with engraftment and dysfunction

    Merani, S., Famulski, K. S., Ramassar, V., James Shapiro, A. M. & Halloran, P. F., Mar 2012
  32. AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro nor after transplantation into immunodeficient mice

    Merani, S., McCall, M., Pawlick, R. L., Edgar, R. L., Davis, J., Toso, C., Emamaullee, J. A., Kin, T. & Shapiro, A. M. J., Nov 2011
  33. Bariatric surgery in serious mental illness

    Merani, S., Gill, R. S., Sharma, A. M., Birch, D. W. & Karmali, S., Oct 2011
  34. The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma

    Merani, S., Majno, P., Kneteman, N. M., Berney, T., Morel, P., Mentha, G. & Toso, C., Oct 2011
  35. Caspase inhibitor therapy synergizes with costimulation blockade to promote indefinite islet allograft survival

    Emamaullee, J. A., Davis, J., Pawlick, R., Toso, C., Merani, S., Cai, S. X., Tseng, B. & Shapiro, A. M. J., Jun 2010
  36. Increasing tuition fees in a country with two different models of medical education

    Merani, S., Abdulla, S., Kwong, J. C., Rosella, L., Streiner, D. L., Johnson, I. L. & Dhalla, I. A., Jun 2010
  37. Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture

    Toso, C., McCall, M., Emamaullee, J., Merani, S., Davis, J., Edgar, R., Pawlick, R., Kin, T., Knudsen, L. B. & Shapiro, A. J., Mar 2010
  38. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma

    Toso, C., Merani, S., Bigam, D. L., Shapiro, A. M. J. & Kneteman, N. M., Apr 2010
  39. AEB-071 has minimal impact on onset of autoimmune diabetes in NOD mice

    Merani, S., Edgar, R. L., Toso, C., Emamaullee, J., Thiesen, A. & Shapiro, A. M. J., 2009
  40. BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice

    Truong, W., Hancock, W. W., Plester, J. C., Merani, S., Rayner, D. C., Thangavelu, G., Murphy, K. M., Anderson, C. C. & Shapiro, A. M. J., Jul 1 2009
  41. Costimulatory blockade with belatacept in clinical and experimental transplantation - A review

    Emamaullee, J., Toso, C., Merani, S. & Shapiro, A. M. J., Jun 2009
  42. Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation

    Toso, C., Edgar, R., Pawlick, R., Emamaullee, J., Merani, S., Dinyari, P., Mueller, T. F., Shapiro, A. M. J. & Anderson, C. C., Feb 2009
  43. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice

    Emamaullee, J. A., Davis, J., Merani, S., Toso, C., Elliott, J. F., Thiesen, A. & Shapiro, A. M. J., Jun 2009
  44. Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide

    Emamaullee, J. A., Merani, S., Toso, C., Kin, T., Al-Saif, F., Truong, W., Pawlick, R., Davis, J., Edgar, R., Lock, J., Bonner-Weir, S., Knudsen, L. B. & Shapiro, A. M. J., May 2009
  45. Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats

    Merani, S., Pawlick, R. L., Edgar, R. L., Toso, C., Emamaullee, J., Anderson, C. C. & Shapiro, A. M. J., Jan 15 2009
  46. Sotrastaurin. Protein kinase C inhibitor treatment of transplant rejection treatment of psoriasis treatment of uveitis

    McCall, M., Merani, S., Toso, C. & Shapiro, A. M. J., Aug 2009
  47. Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity

    Emamaullee, J. A., Merani, S., Larsen, C. P. & Shapiro, A. M. J., Jan 2008
  48. Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts (American Journal of Transplantation (2007) 7, 12, (2663-2674) DOI: 10.1111/j.1600-6143.2007.01996.x)

    Truong, W., Plester, J. C., Hancock, W. W., Merani, S., Murphy, T. L., Murphy, K. M., Kaye, J., Anderson, C. C. & Shapiro, A. M. J., Feb 2008
  49. Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice

    Merani, S., Truong, W., Emamaullee, J. A., Toso, C., Knudsen, L. B. & Shapiro, A. M. J., Sep 2008
  50. Optimal implantation site for pancreatic islet transplantation

    Merani, S., Toso, C., Emamaullee, J. & Shapiro, A. M. J., Dec 2008
  51. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice

    Emamaullee, J. A., Davis, J., Pawlick, R., Toso, C., Merani, S., Cai, S. X., Tseng, B. & Shapiro, A. M. J., Jun 2008
  52. The role of macrophage migration inhibitory factor in mouse islet transplantation

    Toso, C., Serre-Beinier, V., Emamaullee, J., Merani, S., Armanet, M., Wojtusciszyn, A., Bosco, D., Calandra, T., Roger, T., Morel, P., Shapiro, A. M. J. & Berney, T., Nov 27 2008
  53. The role of macrophage migration inhibitory factor on glucose metabolism and diabetes

    Toso, C., Emamaullee, J. A., Merani, S. & Shapiro, A. M. J., Nov 2008
  54. Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts

    Truong, W., Plester, J. C., Hancock, W. W., Merani, S., Murphy, T. L., Murphy, K. M., Kaye, J., Anderson, C. C. & Shapiro, A. M. J., Dec 2007
  55. Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720

    Truong, W., Emamaullee, J. A., Merani, S., Anderson, C. C. & James Shapiro, A. M., Aug 2007
  56. Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival

    Truong, W., Plester, J. C., Hancock, W. W., Kaye, J., Merani, S., Murphy, K. M., Murphy, T. L., Anderson, C. C. & Shapiro, A. M. J., Nov 2007
  57. Chemokines and their receptors in islet allograft rejection and as targets for tolerance induction

    Merani, S., Truong, W. W., Hancock, W., Anderson, C. C. & Shapiro, A. M. J., 2006
  58. Coinhibitory T-cell signaling in islet allograft rejection and tolerance

    Truong, W., Hancock, W. W., Anderson, C. C., Merani, S. & Shapiro, A. M. J., 2006
  59. Compaction of islets is detrimental to transplant outcome in mice

    Merani, S., Schur, C., Truong, W., Knutzen, V. K., Lakey, J. R. T., Anderson, C. C., Ricordi, C. & Shapiro, A. M. J., Dec 2006
  60. Current status of pancreatic islet transplantation

    Merani, S. & Shapiro, A. M. J., Jun 2006
  61. Frontline: Inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: A mimetic of a neuro-endocrine pathway

    Dery, R. E., Ulanova, M., Puttagunta, L., Stenton, G. R., James, D., Merani, S., Mathison, R., Davison, J. & Befus, A. D., Dec 2004
  62. Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

    Stenton, G. R., Ulanova, M., Déry, R. E., Merani, S., Kim, M. K., Gilchrist, M., Puttagunta, L., Musat-Marcu, S., James, D., Schreiber, A. D. & Befus, A. D., Jul 15 2002