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University of Nebraska Medical Center

Moorthy Ponnusamy, PhD - Lab

Moorthy Ponnusamy, PhD
Lab professional holding test tube

Our Research Projects

The lab of Moorthy Ponnusamy focuses on cancer stem cell maintenance and aberrant glycosylation in cancer. Our first research arm investigates the mechanisms of CSC maintenance, while the second research arm examines aberrant glycosylation changes in pancreatic cancer.

Ponnusamy Lab Members

Venkatesh Varadharaj, MSc

PhD Candidate

Venkatesh Varadharaj, MSc

Nivedeta Krishna Kumar, MSc

PhD Candidate

Nivedeta Krishna Kumar

Wyatt Petersen, BS

PhD Candidate

Wyatt Petersen

Kirtana Arikath, BTech

PhD Candidate

Kirtana Arikath

Neenlanjana Gayen, MSc

PhD Candidate

Neelanjana Gayen

Annant Bir Kaur, MS

PhD Candidate

Katie (Katelyn) Thompson, BS

Master's Student

Katie Thompson

Active Grants


  1. 08/12/2022-08/11/2027
    National Institutes of Health, R01CA273349, NIH/NCI
    Title: Truncated O-glycan-dependent mechanisms inducing metastatic dissemination in pancreatic cancer
    Role: Principal Investigator
  2.  08/01/2025-07/31/2026
    Nebraska Dept. of Health and Human Services, LB506
    Title: Oncolytic Virotherapy for Lung Cancers
    Role: Co-Investigator 
  3.  08/09/2022-08/08/2024
    Nebraska Dept. of Health and Human Services, Stem cell 2022-10
    Title: Unique stemness potentiates pancreatic organ-specific metastasis
    Role: Principal Investigator
  4.  06/08/2022 - 05/31/2027
    National Institutes of Health, R01CA273349, NIH/NCI
    Title: Novel therapy to inhibit IPMN progression
    Role: Co-Investigator
  5.  09/01/2022 - 08/31/2027
    National Institutes of Health, R01CA273349, NIH/NCI
    Title: Connectivity mapping identified novel combination therapy for glioblastoma
    Role: Co-Investigator
  6.  2018/06/01-2024/05/31
    National Institutes of Health, P01 CA217798 (PI-Batra, Core director-Ponnusamy)
    Title: Pancreatic Cancer and Metastasis
    Role: Principal Investigator (Histology Core)

Dr Moorthy Ponnusamy receiving the 2025 GSA Distinguished Mentor Award.

Dr. Moorthy Ponnusamy receiving recognition from the Drs. Batra and Britigan.

Ayoola Ogunleye, PhD, graduated in 2025.

Pratima Raut, PhD, graduated in 2025.

Frank Leon, PhD, graduated in 2021.

Dr. Ponnusamy’s student Ramakrishna Nimmakayala, Ph.D, received the Thomas Jefferson award.

Dr. Moorthy Ponnusamy Lab August 2025.

Midwest Student Biomedical Research Forum 2024.

Kritana Arikath, 4th Year PhD Candidate, receiving the 2025 Derry-Crouse Emerging Campus Community Leader Award.

Kritana Arikath, 4th Year PhD Candidate, receiving the Outstanding Community Service Award in the UNMC BMB Annual Symposium 2025.

Dr. Moorthy Ponnusamy lab team members in 2023.

Dr. Moorthy Ponnusamy lab team members received awards at the UNMC BMB Annual Symposium 2025.

Nebraska Academy of Sciences 2023.

Annant Bir Kaur, 4th Year PhD Candidate, receiving the 2024 UNMC Graduate Studies Derry-Crouse Campus Community Leader Award.

Lab members

Nivedeta Krishna Kumar, 4th Year PhD Candidate, received the MSBRF and the BMB first place in oral presentation in the UNMC BMB Annual Symposium 2024.

Venkatesh Varadharaj, 5th Year Ph.D. Candidate in AACR 2025.

Nivedeta KrishnaKumar, 5th Year Ph.D. Candidate and Dr. Moorthy Ponnusamy in AACR 2025.

Midwest Student Biomedical Research Forum 2024.

Nivedeta KrishnaKumar, 5th Year Ph.D. Candidate in AACR 2025.

Nivedeta Krishna Kumar, 5th Year PhD Candidate, awarded the AACR-Barbara Campbell Creighton Scholar-in-Training Award.

Venkatesh Varadharaj and Nivedeta Krishna Kumar, 5th Year PhD Candidates receiving the Community Health Education Award and the Collaboration Award.

Venkatesh Varadharaj, 5th Year Ph.D. Candidate received Outstanding Achievement in Graduate Studies Award.