Keith R. Johnson, Ph.D.

Title: Professor
Nebraska Center for Cellular Signaling, Director
Oral Biology Department

Address: Dr. Keith Johnson
Room: 9.12.394 Buffett Cancer Center
987696 Nebraska Medical Center
University of Nebraska Medical Center
Omaha, NE 68198-7696

Telephone: (402) 559-3890
Fax: (402) 559-4651


Teaching Responsibilities:

Research Interests:

1. Determining which domains of N-cadherin are responsible for down-regulation of the endogenous E-cadherin. These studies involve molecular construction of chimeric cadherins made up of various domains of E-cadherin linked to N-cadherin. These chimeric proteins will be tested for their ability to alter the phenotype of normal squamous epithelial cells.
2. Determining if N-cadherin is unique in its ability to induce a more tumorigenic phenotype. Our hypothesis is that other non-epithelial cadherins may act similar to N-cadherin in this regard. We believe that the ability of a cadherin to induce these changes in epithelial cells will depend on its similarity to the cadherins expressed by mesenchymal tissues.
3. To determine the mechanisms that confer the more invasive phenotype on N-cadherin-expressing oral squamous epithelial cells. These studies include determining alterations in signaling pathways, cellular migration and cell-substratum interactions.