UNMC_Acronym_Vert_sm_4c
University of Nebraska Medical Center

Guda Lab

Our laboratory supports a diverse portfolio of research projects spanning Genomics, Bioinformatics, Machine Learning/Artificial Intelligence (ML/AI), and Drug Discovery.

Current research activities in the Guda Lab broadly fall into the following areas:

  1. Machine Learning and AI for Genomic Big Data
    • We develop and apply advanced ML/AI methodologies to analyze large-scale genomic datasets. Our work includes multi-omics data integration using data science and deep learning approaches, as well as the application of large language models (LLMs) to genomics through transformer architectures and self-attention mechanisms.
  2. In Silico Drug Discovery
    • Our research focuses on identifying non-conventional therapeutic targets, including proteins, fusion transcripts, long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). We develop and implement rapid structure-based and ligand-based virtual screening strategies to efficiently interrogate ultra-large chemical libraries for potential drug candidates.
  3. Algorithm and Pipeline Development for Biomolecular Data Analysis
  • We design novel computational algorithms and scalable data analysis pipelines for diverse biomolecular datasets. These efforts are complemented by experimental validation and the development of user-friendly software platforms and web-based applications to facilitate broader research use.

Principal Investigator

Babu Guda, PhD

Associate Dean for Research Development, UNMC College of Medicine
Professor, Vice Chair for Bioinformatics, Department of Genetics, Cell Biology and Anatomy
Founding Director, Bioinformatics & Systems Biology Core
Founding Co-Director, Center for Biomedical Informatics Research & Innovation

402-559-5954

Headshot of Babu Guda, PhD

Lab News

Researchers receive grant to grow data science pipeline

The National Institutes of Health funding will develop data scientists at UNMC in the area of bioinformatics.

June 13, 2024

Headshots of Andrew Dudley, PhD, and Babu Guda, PhD

UNMC team develops cloud-based genomic data analysis tools

The effort was led by UNMC bioinformatics experts Babu Guda, PhD, and Jordan Rowley, PhD.

October 11, 2023

Headshots of Babu Guda, PhD, and Jordan Rowley, PhD

Research hub under construction will bring together data, AI experts

The biomedical informatics and research lab will be housed on Eppley Science Hall's sixth floor.

September 13, 2023

Construction workers tearing down an interior wall.

NSRI, NU awarded $24.5 million Defense Health Agency contract

Researchers from UNMC and UNL will develop prophylactic protections for acute radiation syndrome.

September 11, 2023

Photo of David Berkowitz, PhD, Maj. Gen. USAF (Ret.) Rick Evans and Ken Bayles, PhD, standing in a lab.

Med center researchers publish breast cancer article in Human Genomics

The study delved into data on cancer mutations from a cohort of 554 regional breast cancer patients.

September 6, 2023

Headshots of Babu Guda, PhD, and Kenneth Cowan, MD, PhD.

New online bioinformatics course designed for INBRE Scholars

The 15-hour course offers an introduction to data in the specialized field and how it's used in research.

June 26, 2023

Image of charts.