University of Nebraska Medical Center

Guda Lab

Our laboratory nurtures a wide range of research projects related to Genomics, Bioinformatics, Systems Biology and Personal Medicine.

The major research projects in my laboratory can be grouped into three broad areas:

  1. Development of novel algorithms for analyzing different types of biomolecular data, followed by experimental validation and development of software and web application tools.
  2. Building data analysis pipelines for processing a variety of high-throughput ‘omics’ datasets (ExomeSeq, RNASeq, ChIPseq, methylation data, miRNA arrays and proteomics data).
  3. Cancer genomics projects that involve integrative data analysis of molecular data across large populations, identification of molecular subtypes of cancers and functional characterization of genes and gene products identified from these studies.

Some of the current research projects in my lab include analysis of breast, pancreatic and glioblastoma cancer genomics data obtained from The Cancer Genome Atlas (TCGA) project, development of novel tools for detecting fusion genes and tumor heterogeneity, and metagenomic profiling of human microbiomes.

Principal Investigator

Professor, Vice Chair for Bioinformatics Research & Training, UNMC Department of Genetics, Cell Biology, and Anatomy
Chief Bioinformatics & Research Computing Officer, UNMC Vice Chancellor for Research Office
Founding Director, UNMC Bioinformatics & Systems Biology Core
Co-Director, UNO & UNMC Center for Biomedical Informatics Research & Innovation
Director, Great Plains IDeA-CTR Biomedical Informatics & Cyberinfrastructure Core


Headshot of Babu Guda, PhD

Lab News

Researchers receive grant to grow data science pipeline

The National Institutes of Health funding will develop data scientists at UNMC in the area of bioinformatics.

Thursday, June 13

Headshots of Andrew Dudley, PhD, and Babu Guda, PhD

UNMC team develops cloud-based genomic data analysis tools

The effort was led by UNMC bioinformatics experts Babu Guda, PhD, and Jordan Rowley, PhD.

Wednesday, October 11

Headshots of Babu Guda, PhD, and Jordan Rowley, PhD

Research hub under construction will bring together data, AI experts

The biomedical informatics and research lab will be housed on Eppley Science Hall's sixth floor.

Wednesday, September 13

Construction workers tearing down an interior wall.

NSRI, NU awarded $24.5 million Defense Health Agency contract

Researchers from UNMC and UNL will develop prophylactic protections for acute radiation syndrome.

Monday, September 11

Photo of David Berkowitz, PhD, Maj. Gen. USAF (Ret.) Rick Evans and Ken Bayles, PhD, standing in a lab.

Med center researchers publish breast cancer article in Human Genomics

The study delved into data on cancer mutations from a cohort of 554 regional breast cancer patients.

Wednesday, September 6

Headshots of Babu Guda, PhD, and Kenneth Cowan, MD, PhD.

New online bioinformatics course designed for INBRE Scholars

The 15-hour course offers an introduction to data in the specialized field and how it's used in research.

Monday, June 26

Image of charts.