College of Medicine
University of Nebraska Medical Center
University of Nebraska Medical Center

Research

My research program spans a broad spectrum of biomedical informatics, including machine learning (ML), explainable-AI, and large language models (LLMs), as well as cancer genomics, computational systems biology, neuroscience, and precision medicine. My laboratory develops novel computational methods and scalable data analysis pipelines that integrate multi-omics data with advanced ML and LLM-based approaches to enable data-driven discovery and translational impact.

To support this work, we have established a robust on-premises high-performance computing environment comprising more than 1,000 CPUs/GPUs and petabyte-scale storage infrastructure. This ecosystem is complemented by extensive expertise in high-performance and cloud computing platforms, including Google Cloud Platform (GCP) and Amazon Web Services (AWS). We routinely leverage these resources to build scalable analytical workflows, develop training modules, and deploy user-friendly, cloud-enabled web applications, including R/Shiny-based tools.

In addition, I serve as the founding Director of the Bioinformatics and Systems Biology (BSB) Core at the University of Nebraska Medical Center (UNMC). The BSB Core currently provides more than 65 specialized bioinformatics services, including next-generation sequencing data analysis; protein docking and structure modeling and virtual screening of ultra-large ligand libraries against therapeutic targets; functional annotation through pathway and network analyses; AI-driven approaches for disease subtyping, prognostic modeling, and biomarker discovery; and the development of online and cloud-based training resources.

Projects

Current Projects    

Collaborations

We have two major collaborations ongoing in our lab:

Bioinformatics and Systems Biology Core

Our laboratory also manages the Bioinformatics and Systems Biology Core facility at UNMC.  The Core provides services on a pay-per-use basis to over 60 independent investigators, most of whom are NIH funded. View more details on the type of services offered through the core.  The Core is also a part of several collaborative projects on campus that include supporting the Data Coordination Center for National NeuroAIDS Consortium and Bioinformatics Core for the INBRE network.