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University of Nebraska Medical Center

H5N1 (Avian Influenza)

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Discover comprehensive information and resources on HPAI H5N1 (Avian Influenza), including updates, situational reports, news, and published research. Explore this page to stay informed about the latest developments and insights HPAI H5N1. 

A graphic of the H5N1 Virus

About HPAI H5N1 

According to the Centers for Disease Control and Prevention (CDC), avian influenza, commonly referred to as bird flu, is caused by infection with avian influenza Type A viruses. These viruses are naturally found in wild aquatic birds worldwide and can infect domestic poultry, as well as other bird and animal species. While bird flu viruses typically do not infect humans, sporadic human infections have been reported.
 
Currently, the Highly Pathogenic Avian Influenza (HPAI) H5N1 strain is spreading globally, affecting wild birds and domestic poultry alike. Additionally, the virus has been identified in  mammals, including dairy cows, foxes, mink, skunks, bears, sea lions, otters, and even domestic cats and dogs.
 
Furthermore, the CDC indicates that the widespread presence of A(H5N1) bird flu viruses among wild birds, poultry, and some mammals—including cows—creates additional exposure opportunities for humans. Consequently, an increase in sporadic human infections may occur due to exposure to birds, cattle, and other infected animals.

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  • As of June 5, 2025, there have been 70 confirmed human cases in the United States, including one fatality associated with the virus. The CDC has stated that there has been no evidence of person-to-person transmission of the virus, and the overall public health risk remains low.
  • As of June 5, 2025:
  • 13,089 wild birds detected as of 6/4/2025 | Full Report
  • 51 jurisdictions with bird flu in wild birds
  • 174,461,898 poultry affected as of 6/2/2025 | Full Report
  • 51 jurisdictions with outbreaks in poultry
  • 1,073 dairy herds affected as of 6/5/2025 | Full Report
  • 17 states with outbreaks in dairy cows
 
Unofficial HPAI H5N1 Map
Data was sourced and imported from FAO EMPRES, USDA APHIS, WAHIS, and open source news reports beginning in late 2022 to current.

 

 
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The GCHS, in collaboration with the Region VII Disaster Health Response Ecosystem (R7DHRE) conducts biweekly meetings with local and state public health and healthcare representatives. These meetings focus on reviewing and discussing recent developments related to current infectious disease challenges. Dr. James V. Lawler, MD, MPH, FIDSA, presents comprehensive updates on data and advancements at local, state, national, and international levels. Additionally, regional experts offer insights into current outbreaks and clinical situations within Region 7. Register here. 

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