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University of Nebraska Medical Center

Is the New Mpox ‘Outbreak’ Deadlier?

Medpage Today

Three factors could explain the higher case fatality rate in the Democratic Republic of the Congo. An outbreak* of mpox (formerly known as monkeypox) has been detected in the Democratic Republic of the Congo (DRC). The World Health Organization (WHO) has reported that the case fatality rate — the percent of detected cases that are fatal — is 4.6%, or one in 22. That represents 581 deaths among 12,569 suspected cases in the 2023 outbreak. This is high. By comparison, the mpox outbreak of 2022 that was declared a “public health emergency of international concern” by the WHO had a case fatality rate of 0.18%, or one in 500. In the DRC, the case fatality rate of the 2022 outbreak was similar to the global rate, at around 0.2%. (The official international emergency that started in July 2022 ended in May 2023. While technically the current cases are an “escalation” of a longstanding mpox outbreak in the DRC, for the sake of clarity, I’ll use the terminology of the 2022/Clade II and 2023/Clade I outbreaks here.)

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