Global Biodefense Unusual spike in human infections highlights ongoing risks at the human-animal interface and the need for cross-sectoral public health action. Between January and July 2025, Cambodian health authorities reported 11 laboratory-confirmed cases of human infection with avian influenza A(H5N1), including six fatalities. Notably, seven of these cases occurred in June alone—an unusual monthly spike. These recent infections are part of a broader resurgence that began in February 2023, after nearly a decade without reported human cases in the country. Since that re-emergence, Cambodia has confirmed 27 human infections, with a case fatality ratio (CFR) of 44%.
The recurrence of H5N1 in humans underscores persistent vulnerabilities at the human-animal interface and raises critical concerns about surveillance, biosecurity, and pandemic preparedness in regions where the virus remains endemic in animal populations.
Fair Use Notice
UNMC Global Center for Health Security staff curate publicly available news and information for educational and informational purposes. Brief excerpts of published articles may be displayed under principles of Fair Use, with credit and links provided to the source publications. All copyrights remain the property of their respective owners.