MedPageToday Large study reinforces recent research demonstrating mRNA vaccine safety in pregnancy. There were 176.6 major congenital malformations (MCMs) per 10,000 infants exposed to first-trimester COVID-19 mRNA vaccines, compared with 179.4 per 10,000 infants not exposed to the vaccines.
There were no associations between mRNA vaccine exposure and MCMs by organ system.
There was no difference in the rate of stillbirths between pregnant women who received mRNA vaccines and those who didn’t (both 0.4%). Fetal exposure to maternal COVID-19 mRNA vaccines in the first trimester of pregnancy wasn’t linked to an increased risk of 75 major congenital malformations (MCMs), according to a large French cohort study of pregnant women and their infants.