Category: COVID
Nature – Understanding the epidemic growth of the novel SARS-CoV-2 Omicron variant is critical for public health. We compared the ten-day secondary attack rate (SAR) of the Omicron and Delta variants in households using Norwegian contact tracing data, December 2021 – January 2022. Omicron SAR was higher than Delta, with a relative risk (RR) of […]
Sep 29, 2022
Translational Research and Clinical Interventions – Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third […]
Sep 29, 2022
Study aims to understand how SARS-CoV-2 affects the brain long-term
Medical News – In addition to the lungs, COVID-19 also affects the central nervous system (CNS) through anoxic, viral neurotoxicity, inflammation, and cerebrovascular mechanisms. As a result, about one-third of COVID-19 patients develop different neurologic problems, such as seizures, loss of sense of smell or taste, and stroke. Related study in Translational Research and Clinical Interventions
Sep 29, 2022
The Lancet – Singapore offered the BNT162b2 vaccine (tozinameran; Pfizer-BioNTech) to adolescents aged 12–17 years in May 18, 2021, and extended booster vaccines to this group in Jan 21, 2022. Literature on the effectiveness of primary series and booster vaccination among adolescents is scarce outside of Europe and North America. We aimed to determine primary […]
Sep 29, 2022
What comes after Omicron? New variants are emerging.
National Geographic – Infections over the last three months have been dominated by new sublineages of Omicron: BA.2, BA.2.12.1, BA.4., and BA.5. In the U.K., symptomatic infections have steadily increased since August 27—the day they hit lowest level this year—according to the ZOE COVID-19 study, an App-based project in which patients enter their symptoms on their […]
Sep 29, 2022
Mental Health During the COVID-19 Pandemic
NIH – Both SARS-CoV-2 and the COVID-19 pandemic have significantly affected the mental health of adults and children. In a 2021 study, nearly half of Americans surveyed reported recent symptoms of an anxiety or depressive disorder, and 10% of respondents felt their mental health needs were not being met. Rates of anxiety, depression, and substance […]
Sep 29, 2022
Repurposing existing drugs to fight new COVID-19 variants
Michigan State University – MSU researchers are using big data and AI to identify current drugs that could be applied to treat new COVID-19 variants. Finding new ways to treat the novel coronavirus and its ever-changing variants has been a challenge for researchers, especially when the traditional drug development and discovery process can take years. […]
Sep 29, 2022
JAMA – Question Is SARS-CoV-2 seropositivity associated with symptoms of myalgic encephalomyelitis and/or chronic fatigue syndrome (ME/CFS) in children and adolescents? Findings This cross-sectional study of hospital-based SARS-CoV-2 seroprevalence surveys in Germany compared seropositive and seronegative children and adolescents and identified an excess of possible ME/CFS symptoms with serological evidence of preceding SARS-CoV-2 infection. This association almost […]
Sep 28, 2022
Remdesivir resistance in transplant recipients with persistent COVID-19
Clinical Infectious Diseases – New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications. Download […]
Sep 28, 2022