University of Nebraska Medical Center

Discovery of Lens Epithelium-Derived Protein

Lens epithelium-derived protein, a protein essential for ER-Golgi homeostasis (quality control)

Dr. Singh’s research team believes that there is a need to isolate and characterize more new genes in the eye lens in order to better understand lens biology. To this end, the group isolated and cloned. This protein with a molecular mass of 132kD protects cells from ER-stress by correcting unfolded protein response. Now his team is exploring the molecular mechanism of action of this protein. 

The schematic representation of putative protein domains and function of mammalian LEDP/132 and subcellular localization

Graphic showing Subcellular distribution pattern of LEDP/132.
Graphic showing the general mechanism of GEF-induced nucleotide exchange