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University of Nebraska Medical Center

South Carolina Measles Outbreak Becomes Largest In U.S. History Since First Elimination

Forbes South Carolina’s growing measles outbreak is now the largest in United States history since the contagious viral disease was declared eliminated more than two decades ago in the wake of widespread vaccinations, according to a report from CNN. Big Number

88%. That’s the proportion of measles cases in South Carolina that have appeared in unvaccinated individuals, according to statistics shared by the state health department.

Crucial Quote

“We feel like we’re really kind of staring over the edge, knowing that this is about to get a lot worse,” said Dr. Johnathon Elke of South Carolina-based Prisma Health at a press briefing early this year.

Key Background

Measles cases have been booming in South Carolina since the start of the new year. As of last Friday, the state health authority had confirmed 416 cases since it began tracking the outbreak in late September. The updated count represents an increase of 90% in under a week. Childhood vaccinations against measles have been declining, according to Harvard Health. Rates among school-age kids fell from 95% in 2019 to 92% in 2023. The spread is happening at a faster rate than the 2025 nationwide outbreak, when the highly contagious disease made its biggest comeback in three decades, resulting in 2,255 confirmed cases for the year, according to data from the CDC.

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