Category: Published Research
Nature Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here […]
Apr 24, 2024
Nature One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. […]
Apr 10, 2024
Clinical Infectious Diseases Abstract Background Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described. Methods In this controlled case-ascertained household transmission study, we recruited asymptomatic children <18 years with SARS-CoV-2 nucleic acid testing performed at 12 tertiary care pediatric institutions in Canada and the United States. […]
Mar 27, 2024
Ecological countermeasures to prevent pathogen spillover and subsequent pandemics
Nature Substantial global attention is focused on how to reduce the risk of future pandemics. Reducing this risk requires investment in prevention, preparedness, and response. Although preparedness and response have received significant focus, prevention, especially the prevention of zoonotic spillover, remains largely absent from global conversations. This oversight is due in part to the lack […]
Mar 26, 2024
JAMA Question Is an artificial intelligence (AI) deterioration model–enabled intervention associated with a decreased risk of escalations in care during hospitalization? Findings In this cohort study of 9938 patients hospitalized at a single academic center in 2021 and 2022, exposure to the intervention was associated with a 10.4–percentage point absolute risk reduction in the primary composite outcome […]
Mar 26, 2024
Nature Neurological symptoms, including cognitive impairment and fatigue, can occur in both the acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the mechanisms that contribute to this remain unclear. Here we profiled single-nucleus transcriptomes and proteomes of brainstem tissue from deceased individuals at various stages of COVID-19. We detected an […]
Feb 20, 2024
The Lancet Microbe The Democratic Republic of the Congo has had 15 Ebola virus disease (EVD) outbreaks, from 1976 to 2023. On June 1, 2020, the Democratic Republic of the Congo declared an outbreak of EVD in the western Équateur Province (11th outbreak), proximal to the 2018 Tumba and Bikoro outbreak and concurrent with an outbreak […]
Jan 23, 2024
Fast evolution of SARS-CoV-2 BA.2·86 to JN.1 under heavy immune pressure
The Lancet The SARS-CoV-2 saltation variant BA.2.86, which was quickly designated as a variant under monitoring after its emergence, has garnered global attention. Although BA.2.86 did not show substantial humoral immune escape and growth advantage compared with current dominant variants, such as EG.5.1 and HK.3, it showed remarkably high ACE2 binding affinity. This increased binding […]
Dec 19, 2023
Replication-Competent Virus Detected in Blood of a Fatal COVID-19 Case
Annals of Internal Medicine Background: SARS-CoV-2 infects respiratory tissues, and in some cases, replication-competent virus has been detected in extrapulmonary tissues, including brain (1). Viremic spread is suspected, and detection of viral RNA in blood is frequently reported (2). However, recovery of replication-competent virus from blood has not been previously demonstrated (3, 4). Objective: To confirm viremia in […]
Dec 12, 2023
Nature The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration […]
Dec 12, 2023